Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Moira K. O'Bryan"'
Autor:
Brendan J. Houston, Joseph Nguyen, D. Jo Merriner, Anne E. O’Connor, Alexandra M. Lopes, Liina Nagirnaja, Corinna Friedrich, Sabine Kliesch, Frank Tüttelmann, Kenneth I. Aston, Donald F. Conrad, Robin M. Hobbs, Jessica E. M. Dunleavy, Moira K. O’Bryan
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-14 (2024)
Abstract Dynein complexes are large, multi-unit assemblies involved in many biological processes via their critical roles in protein transport and axoneme motility. Using next-generation sequencing of infertile men presenting with low or no sperm in
Externí odkaz:
https://doaj.org/article/38d67cff45b24f41b04e0df254fa2667
Autor:
Anna-Grete Juchnewitsch, Kristjan Pomm, Avirup Dutta, Erik Tamp, Anu Valkna, Kristiina Lillepea, Eisa Mahyari, Stanislav Tjagur, Galina Belova, Viljo Kübarsepp, Helen Castillo-Madeen, Antoni Riera-Escamilla, Lisanna Põlluaas, Liina Nagirnaja, Olev Poolamets, Vladimir Vihljajev, Mailis Sütt, Nassim Versbraegen, Sofia Papadimitriou, Robert I. McLachlan, Keith A. Jarvi, Peter N. Schlegel, Sven Tennisberg, Paul Korrovits, Katinka Vigh-Conrad, Moira K. O’Bryan, Kenneth I. Aston, Tom Lenaerts, Donald F. Conrad, Laura Kasak, Margus Punab, Maris Laan
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
RASopathies are syndromes caused by congenital defects in the Ras/mitogen-activated protein kinase (MAPK) pathway genes, with a population prevalence of 1 in 1,000. Patients are typically identified in childhood based on diverse characteristic featur
Externí odkaz:
https://doaj.org/article/a5a26794d89e45529badd269302ae0fc
Autor:
Sarah N. Biggs, Joanne Kennedy, Sharon L. Lewis, Stephen Hearps, Moira K. O’Bryan, Robert McLachlan, Simon von Saldern, Georgina Chambers, Jane Halliday
Publikováno v:
Reproductive Health, Vol 20, Iss 1, Pp 1-9 (2023)
Plain language summary Approximately 1 in 20 men are sub-fertile or infertile yet very little is known about the causes of male infertility. Research has suggested that lifestyle choices and environmental factors contribute to infertility, but more n
Externí odkaz:
https://doaj.org/article/6aecb4c5d18a4a4783f429e67caf8771
Autor:
Liina Nagirnaja, Alexandra M. Lopes, Wu-Lin Charng, Brian Miller, Rytis Stakaitis, Ieva Golubickaite, Alexandra Stendahl, Tianpengcheng Luan, Corinna Friedrich, Eisa Mahyari, Eloise Fadial, Laura Kasak, Katinka Vigh-Conrad, Manon S. Oud, Miguel J. Xavier, Samuel R. Cheers, Emma R. James, Jingtao Guo, Timothy G. Jenkins, Antoni Riera-Escamilla, Alberto Barros, Filipa Carvalho, Susana Fernandes, João Gonçalves, Christina A. Gurnett, Niels Jørgensen, Davor Jezek, Emily S. Jungheim, Sabine Kliesch, Robert I. McLachlan, Kenan R. Omurtag, Adrian Pilatz, Jay I. Sandlow, James Smith, Michael L. Eisenberg, James M. Hotaling, Keith A. Jarvi, Margus Punab, Ewa Rajpert-De Meyts, Douglas T. Carrell, Csilla Krausz, Maris Laan, Moira K. O’Bryan, Peter N. Schlegel, Frank Tüttelmann, Joris A. Veltman, Kristian Almstrup, Kenneth I. Aston, Donald F. Conrad
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The GEMINI consortium sequenced 1,000 cases of idiopathic male infertility and identified a plausible Mendelian cause in 20% of cases. The infertility genes can be grouped by expression pattern, facilitating their interpretation and follow-up.
Externí odkaz:
https://doaj.org/article/d33757f275f346459883626f17daf68f
Autor:
Wing-Hong Jonathan Ho, Andrew M. K. Law, Etienne Masle-Farquhar, Lesley E. Castillo, Amanda Mawson, Moira K. O’Bryan, Christopher C. Goodnow, David Gallego-Ortega, Samantha R. Oakes, Christopher J. Ormandy
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-14 (2022)
Abstract Background The interferon response can influence the primary and metastatic activity of breast cancers and can interact with checkpoint immunotherapy to modulate its effects. Using N-ethyl-N-nitrosourea mutagenesis, we found a mouse with an
Externí odkaz:
https://doaj.org/article/b46a129834b748d4b3d442674bc2a867
Autor:
Mohammad Reza Raveshi, Melati S. Abdul Halim, Sagar N. Agnihotri, Moira K. O’Bryan, Adrian Neild, Reza Nosrati
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The effect of fallopian tube’s curvature on sperm motion has not been studied in detail. Here, the authors use droplet microfluidics to create soft curved interfaces, revealing a dynamic switch in sperm motility from a progressive surface-aligned m
Externí odkaz:
https://doaj.org/article/c286dee44f554582b146eaea5cc01de5
Autor:
Junyang Gai, Esma Dervisevic, Citsabehsan Devendran, Victor J. Cadarso, Moira K. O'Bryan, Reza Nosrati, Adrian Neild
Publikováno v:
Advanced Science, Vol 9, Iss 11, Pp n/a-n/a (2022)
Abstract Sperm motility is a significant predictor of male fertility potential and is directly linked to fertilization success in both natural and some forms of assisted reproduction. Sperm motility can be impaired by both genetic and environmental f
Externí odkaz:
https://doaj.org/article/33b4d0dcd14a4bd69e1777e270b51598
Autor:
Brendan J. Houston, Manon S. Oud, Daniel M. Aguirre, D. Jo Merriner, Anne E. O’Connor, Ozlem Okutman, Stéphane Viville, Richard Burke, Joris A. Veltman, Moira K. O’Bryan
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 12, Pp 4449-4457 (2020)
Externí odkaz:
https://doaj.org/article/a7a59dd16d164fee95bf95fa6b6d41d2
Autor:
Nicola D. Kolaitis, Bethany J. Finger, D. Jo Merriner, Joseph Nguyen, Brendan J. Houston, Moira K. O’Bryan, Jessica M. Stringer, Nadeen Zerafa, Ngoc Nguyen, Karla J. Hutt, Gerard A. Tarulli, Mark P. Green
Publikováno v:
Cells, Vol 12, Iss 4, p 648 (2023)
A common herbicide, atrazine, is associated with poor health. Atrazine acts as an endocrine disruptor at supra-environmental levels. Little research, however, has been conducted regarding chronic exposure to environmental atrazine concentrations acro
Externí odkaz:
https://doaj.org/article/8cd9e5dbc5724e82bdb3a848e25780d7
Autor:
Arthur S. Lee, Jannette Rusch, Ana C. Lima, Abul Usmani, Ni Huang, Maarja Lepamets, Katinka A. Vigh-Conrad, Ronald E. Worthington, Reedik Mägi, Xiaobo Wu, Kenneth I. Aston, John P. Atkinson, Douglas T. Carrell, Rex A. Hess, Moira K. O’Bryan, Donald F. Conrad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Many molecular and physiological mechanisms in the regulation of fertility are shared between female and male mammals. Here, Lee et al. report an association of CNVs in CSMD1 with early idiopathic menopause in women and show that loss of Csmd1 leads
Externí odkaz:
https://doaj.org/article/60cd321fd0b3463ab76d53b0cfcb3f9d