Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Moira Behn"'
1
Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild-type p53 protein in human glioblastoma cells
Autor: Marcus Schuermann, Juergen Schlegel, Frauke Neff, Alison Kraus, Kristin Muenkel, Moira Behn
Publikováno v: International Journal of Cancer. 80:930-934
A puzzling finding in various human tumors, including glioblastoma multiforme (GBM), is the stabilization of wild-type (wt) p53 protein. The biological significance of this phenomenon and the mechanism by which it occurs are unexplained. Recent repor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c195bbba5685c6a8a366860904c674f
https://doi.org/10.1002/(sici)1097-0215(19990315)80:6<930::aid-ijc20>3.0.co
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2
Functional domains in cyclin D1: pRb-kinase activity is not essential for transformation
Autor: F. C. Lucibello, Karin U Jooss, Andreas Sewing, Jörk Zwicker, Moira Behn, Sabine Brüsselbach, Rolf Müller
Publikováno v: Oncogene. 18:19-25
Although cyclin D1 plays a major role during cell cycle progression and is involved in human tumourigenesis, its domain structure is still poorly understood. In the present study, we have generated a series of cyclin D1 N- and C-terminal deletion con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cd35287806939a9ec72615843d3830
https://doi.org/10.1038/sj.onc.1202286
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3
Sensitive detection of p53 gene mutations by a 'mutant enriched' PCR- SSCP technique
Autor: Marcus Schuermann, Moira Behn
Publikováno v: Nucleic Acids Research. 26:1356-1358
For the rapid and sensitive detection of p53 'hot spot' mutations, we combined polymerase chain reaction based single-strand conformational polymorphism (PCR-SSCP) analysis with sequence specific-clamping by peptide nucleic acids (PNAs) in a one-step
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec17d9a582599b56f0afae435a9b92b
https://doi.org/10.1093/nar/26.5.1356
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6
Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers
Autor: C. Friedl, Marcus Schuermann, W. Pankow, Moira Behn, Alison Kraus, M. Kersting
Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 18(18)
PURPOSE: The aim of this study was to investigate the frequency of three (epi)genetic alterations (p53 and K-ras mutations and p16INK4a promoter hypermethylation) in symptomatic chronic smokers compared with patients with lung cancer and to evaluate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07987ec7aaffeb5462b326153e8e9c4
https://pubmed.ncbi.nlm.nih.gov/10986054
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7
Simple and reliable factor V genotyping by PNA-mediated PCR clamping
Autor: Marcus Schuermann, Moira Behn
Publikováno v: Thrombosis and haemostasis. 79(4)
SummaryResistance to activated protein C (APC resistance) is the most common cause of thrombophilia and linked to a single point mutation in the factor V gene (G>A transition at nucleotide 1691). In the past, several PCR based methods have been propo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b8d7278a32160df4a82e3be7ebf005
https://pubmed.ncbi.nlm.nih.gov/9569191
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