Zobrazeno 1 - 10
of 337
pro vyhledávání: '"Moin A, Saleem"'
Autor:
Amy J. Osborne, Agnieszka Bierzynska, Elizabeth Colby, Uwe Andag, Philip A. Kalra, Olivier Radresa, Philipp Skroblin, Maarten W. Taal, Gavin I. Welsh, Moin A. Saleem, Colin Campbell
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Chronic kidney diseases (CKD) have genetic associations with kidney function. Univariate genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with estimated glomerular filtration rate (eGFR
Externí odkaz:
https://doaj.org/article/720dcb90cc644525b4ddd6be5815d98b
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101333- (2024)
Chronic kidney disease (CKD) poses a significant global health challenge, projected to become one of the leading causes of death by 2040. Current treatments primarily manage complications and slow progression, highlighting the urgent need for persona
Externí odkaz:
https://doaj.org/article/35ec8e53f7f8421a86be1722d96a5daf
Autor:
Natalie Ives, Rebecca Woolley, Moin A Saleem, Catherine A Moakes, Aoife Waters, Rodney D Gilbert, Hugh Jarrett, Elizabeth Brettell, Steve Nash, Louise K Farmer, Khadija Ourradi, Sally A Johnson
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 11, Iss 11 (2024)
Background Shiga-toxin-producing Escherichia coli haemolytic uraemic syndrome affects ~100 United Kingdom children each year. Around half need dialysis, a quarter develop serious complications with long-term consequences and ~3% die. No effective int
Externí odkaz:
https://doaj.org/article/d211a98eb57e4132bc1c294a564bffab
Autor:
Martin Bezdicka, Ondrej Cinek, Valerij Semjonov, Katerina Polackova, Eva Sladkova, Jakub Zieg, Moin A. Saleem, Ondrej Soucek
Publikováno v:
Physiological Reports, Vol 12, Iss 3, Pp n/a-n/a (2024)
Abstract As the molecular mechanism of nephrotic syndrome remains largely undiscovered, patients continue to be exposed to the pros and cons of uniform glucocorticoid treatment. We explored whether the exposure of in vitro‐cultivated podocytes to s
Externí odkaz:
https://doaj.org/article/4afec8f4782b4ff0a5731de33a040a5e
Autor:
Irena Audzeyenka, Maria Szrejder, Dorota Rogacka, Stefan Angielski, Moin A. Saleem, Agnieszka Piwkowska
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Podocytes constitute an external layer of the glomerular filtration barrier, injury to which is a hallmark of renal disease. Mitochondrial dysfunction often accompanies podocyte damage and is associated with an increase in oxidative stress a
Externí odkaz:
https://doaj.org/article/3c41d022e2b84732bf31cc0b1d6e3a94
Autor:
Maria D. Sanchez-Niño, Maria I. Ceballos, Sol Carriazo, Aranzazu Pintor-Chocano, Ana B. Sanz, Moin A. Saleem, Alberto Ortiz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15853 (2023)
Fabry disease is a lysosomal disease characterized by globotriaosylceramide (Gb3) accumulation. It may coexist with diabetes mellitus and both cause potentially lethal kidney end-organ damage. However, there is little information on their interaction
Externí odkaz:
https://doaj.org/article/449ba6e8257044b98248ab41330ed383
Autor:
Jack Tuffin, Musleeha Chesor, Valeryia Kuzmuk, Tim Johnson, Simon C. Satchell, Gavin I. Welsh, Moin A. Saleem
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Tuffin et al. demonstrate a method for culturing conditionally immortalized human podocytes and GEnCs in 3D by forming spheroid cultures termed GlomSpheres, which are found to segregate in an organized manner. These are shown to establish a GBM-like
Externí odkaz:
https://doaj.org/article/3454bab16428421b8cab931ece01a44c
Autor:
Rim Bouslama, Vincent Dumont, Sonja Lindfors, Lassi Paavolainen, Jukka Tienari, Harry Nisen, Tuomas Mirtti, Moin A. Saleem, Daniel Gordin, Per-Henrik Groop, Shiro Suetsugu, Sanna Lehtonen
Publikováno v:
Cells, Vol 12, Iss 11, p 1487 (2023)
Changes in the dynamic architecture of podocytes, the glomerular epithelial cells, lead to kidney dysfunction. Previous studies on protein kinase C and casein kinase 2 substrates in neurons 2 (PACSIN2), a known regulator of endocytosis and cytoskelet
Externí odkaz:
https://doaj.org/article/051c46658c344b7d80aa86068b022ab4
Autor:
Eriko Hamasaki, Natsuki Wakita, Hiroki Yasuoka, Hikaru Nagaoka, Masayuki Morita, Eizo Takashima, Takayuki Uchihashi, Tetsuya Takeda, Tadashi Abe, Ji-Won Lee, Tadahiro Iimura, Moin A Saleem, Naohisa Ogo, Akira Asai, Akihiro Narita, Kohji Takei, Hiroshi Yamada
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Dynamin is an endocytic protein that functions in vesicle formation by scission of invaginated membranes. Dynamin maintains the structure of foot processes in glomerular podocytes by directly and indirectly interacting with actin filaments. However,
Externí odkaz:
https://doaj.org/article/d8d684637941406b9a5dac408770ee49
Autor:
Julian Trah, Jonas Arand, Jun Oh, Laia Pagerols-Raluy, Magdalena Trochimiuk, Birgit Appl, Hannah Heidelbach, Deirdre Vincent, Moin A. Saleem, Konrad Reinshagen, Anne K. Mühlig, Michael Boettcher
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract Lithocholic bile acid (LCA) has been reported to selectively kill cancer cells within many tumor cell lines including neuroblastoma or glioblastoma. Wilms’ tumor shares similarities with neuro- and glioblastoma. Hence, the aim of the study
Externí odkaz:
https://doaj.org/article/861855d3ccca4b3b99dc20358a396b22