SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Autor: Neale, Benjamin M., Daly, Mark, Ganna, Andrea, Stevens, Christine, Pathak, Gita A., Andrews, Shea J., Kanai, Masahiro, Cordioli, Mattia, Karjalainen, Juha, Polimanti, Renato, Pirinen, Matti, Harerimana, Nadia, Veerapen, Kumar, Wolford, Brooke, Nguyen, Huy, Solomonson, Matthew, Liao, Rachel G., Chwialkowska, Karolina, Trankiem, Amy, Balaconis, Mary K., Hayward, Caroline, Richmond, Anne, Campbell, Archie, Morris, Marcela, Fawns-Ritchie, Chloe, Glessner, Joseph T., Shaw, Douglas M., Chang, Xiao, Polikowski, Hannah, Lauren, Petty E., Chen, Hung-Hsin, Wanying, Zhu, Hakonarson, Hakon, Porteous, David J., Below, Jennifer, North, Kari, McCormick, Joseph B., Timmers, Paul R.H.J., Wilson, James F., Tenesa, Albert, D’Mellow, Kenton, Kerr, Shona M., Niemi, Mari E.K., Nkambul, Lindokuhle, Aprile von Hohenstaufen, Kathrin, Sobh, Ali, Eltoukhy, Madonna M., Yassen, Amr M., Hegazy, Mohamed A.F., Okasha, Kamal, Eid, Mohammed A., Moahmed, Hanteera S., Shahin, Doaa, El-Sherbiny, Yasser M., Elhadidy, Tamer A., Abd Elghafar, Mohamed S., El-Jawhari, Jehan J., Mohamed, Attia A.S., Elnagdy, Marwa H., Samir, Amr, Abdel-Aziz, Mahmoud, Khafaga, Walid T., El-Lawaty, Walaa M., Torky, Mohamed S., El-shanshory, Mohamed R., Batini, Chiara, Lee, Paul H., Shrine, Nick, Williams, Alexander T., Tobin, Martin D., Guyatt, Anna L., John, Catherine, Packer, Richard J., Ali, Altaf, Free, Robert C., Wang, Xueyang, Wain, Louise V., Hollox, Edward J., Venn, Laura D., Bee, Catherine E., Adams, Emma L., Niavarani, Ahmadreza, Sharififard, Bahareh, Aliannejad, Rasoul, Amirsavadkouhi, Ali, Naderpour, Zeinab, Tadi, Hengameh Ansari, Aleagha, Afshar Etemadi, Ahmadi, Saeideh, Mohseni Moghaddam, Seyed Behrooz, Adamsara, Alireza, Saeedi, Morteza, Abdollahi, Hamed, Hosseini, Abdolmajid, Chariyavilaskul, Pajaree, Chamnanphon, Monpat, Suttichet, Thitima B., Shotelersuk, Vorasuk, Pongpanich, Monnat, Phokaew, Chureerat, Chetruengchai, Wanna, Jantarabenjakul, Watsamon, Putchareon, Opass, Torvorapanit, Pattama, Puthanakit, Thanyawee, Suchartlikitwong, Pintip, Hirankarn, Nattiya, Nilaratanakul, Voraphoj, Sodsai, Pimpayao, Brumpton, Ben M., Hveem, Kristian, Willer, Cristen, Zhou, Wei, Rogne, Tormod, Solligard, Erik, Åsvold, Bjørn Olav, Abedalthagafi, Malak, Alaamery, Manal, Alqahtani, Saleh, Baraka, Dona, Al Harthi, Fawz, Alsolm, Ebtehal, Safieh, Leen Abu, Alowayn, Albandary M., Alqubaishi, Fatimah, Al Mutairi, Amal, Mangul, Serghei, Alshareef, Abdulraheem, Sawaji, Mona, Almutairi, Mansour, Aljawini, Nora, Albesher, Nour, Arabi, Yaseen M., Mahmoud, Ebrahim S., Khattab, Amin K., Halawani, Roaa T., Alahmadey, Ziab Z., Albakri, Jehad K., Felemban, Walaa A., Suliman, Bandar A., Hasanato, Rana, Al-Awdah, Laila, Alghamdi, Jahad, AlZahrani, Deema, AlJohani, Sameera, Al-Afghani, Hani, Alrashed, May, AlDhawi, Nouf, AlBardis, Hadeel, Alkwai, Sarah, Alswailm, Moneera, Almalki, Faisal, Albeladi, Maha, Almohammed, Iman, Barhoush, Eman, Albader, Anoud, Massadeh, Salam, AlMalik, Abdulaziz, Alotaibi, Sara, Alghamdi, Bader, Jung, Junghyun, Fawzy, Mohammad S., Lee, Yunsung, Magnus, Per, Trogstad, Lill-Iren S., Helgeland, Øyvind, Harris, Jennifer R., Mangino, Massimo, Spector, Tim D., Emma, Duncan, Smieszek, Sandra P., Przychodzen, Bartlomiej P., Polymeropoulos, Christos, Polymeropoulos, Vasilios, Polymeropoulos, Mihael H., Fernandez-Cadenas, Israel, Perez-Tur, Jordi, Llucià-Carol, Laia, Cullell, Natalia, Muiño, Elena, Cárcel-Márquez, Jara, DeDiego, Marta L., Iglesias, Lara Lloret, Planas, Anna M., Soriano, Alex, Rico, Veronica, Agüero, Daiana, Bedini, Josep L., Lozano, Francisco, Domingo, Carlos, Robles, Veronica, Ruiz-Jaén, Francisca, Márquez, Leonardo, Gomez, Juan, Coto, Eliecer, Albaiceta, Guillermo M., García-Clemente, Marta, Dalmau, David, Arranz, Maria J., Dietl, Beatriz, Serra-Llovich, Alex, Soler, Pere, Colobrán, Roger, Martín-Nalda, Andrea, Martínez, Alba Parra, Bernardo, David, Rojo, Silvia, Fiz-López, Aida, Arribas, Elisa, Cal-Sabater, Paloma de la, Segura, Tomás, González-Villa, Esther, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Jiménez-Xarrié, Elena, de Felipe Mimbrera, Alicia, Masjuan, Jaime, García-Madrona, Sebastian, Domínguez-Mayoral, Anna, Villalonga, Joan Montaner, Menéndez-Valladares, Paloma, Chasman, Daniel I., Buring, Julie E., Ridker, Paul M., Franco, Giulianini, Sesso, Howard D., Manson, JoAnn E., Glessner, Joseph R., Medina-Gomez, Carolina, Uitterlinden, Andre G., Ikram, M. Arfan, Kristiansson, Kati, Koskelainen, Sami, Perola, Markus, Donner, Kati, Kivinen, Katja, Palotie, Aarno, Ripatti, Samuli, Ruotsalainen, Sanni, Kaunisto, Mari, FinnGen, Nakanishi, Tomoko, Butler-Laporte, Guillaume, Forgetta, Vincenzo, Morrison, David R., Ghosh, Biswarup, Laurent, Laetitia, Belisle, Alexandre, Henry, Danielle, Abdullah, Tala, Adeleye, Olumide, Mamlouk, Noor, Kimchi, Nofar, Afrasiabi, Zaman, Branka Vulesevic, Nardin Rezk, Bouab, Meriem, Guzman, Charlotte, Petitjean, Louis, Tselios, Chris, Xue, Xiaoqing, Schurr, Erwin, Afilalo, Jonathan, Afilalo, Marc, Oliveira, Maureen, Brenner, Bluma, Lepage, Pierre, Ragoussis, Jiannis, Auld, Daniel, Brassard, Nathalie, Durand, Madeleine, Chassé, Michaël, Kaufmann, Daniel E., Lathrop, G. Mark, Mooser, Vincent, Richards, J. Brent, Li, Rui, Adra, Darin, Rahmouni, Souad, Georges, Michel, Moutschen, Michel, Misset, Benoit, Darcis, Gilles, Guiot, Julien, Guntz, Julien, Azarzar, Samira, Gofflot, Stéphanie, Beguin, Yves, Claassen, Sabine, Malaise, Olivier, Huynen, Pascale, Meuris, Christelle, Thys, Marie, Jacques, Jessica, Léonard, Philippe, Frippiat, Frederic, Giot, Jean-Baptiste, Sauvage, Anne-Sophie, Von Frenckell, Christian, Belhaj, Yasmine, Lambermont, Bernard, Pigazzini, Sara, Nkambule, Lindokuhle, Daya, Michelle, Shortt, Jonathan, Rafaels, Nicholas, Wicks, Stephen J., Crooks, Kristy, Barnes, Kathleen C., Gignoux, Christopher R., Chavan, Sameer, Laisk, Triin, Läll, Kristi, Lepamets, Maarja, Mägi, Reedik, Esko, Tõnu, Reimann, Ene, Milani, Lili, Alavere, Helene, Metsalu, Kristjan, Puusepp, Mairo, Metspalu, Andres, Naaber, Paul, Laane, Edward, Pesukova, Jaana, Peterson, Pärt, Kisand, Kai, Tabri, Jekaterina, Allos, Raili, Hensen, Kati, Starkopf, Joel, Ringmets, Inge, Tamm, Anu, Kallaste, Anne, Bochud, Pierre-Yves, Rivolta, Carlo, Bibert, Stéphanie, Quinodoz, Mathieu, Kamdar, Dhryata, Boillat, Noémie, Nussle, Semira Gonseth, Albrich, Werner, Suh, Noémie, Neofytos, Dionysios, Erard, Véronique, Voide, Cathy, FHoGID, RegCOVID, P-PredictUs, SeroCOVID, CRiPSI, de Cid, Rafael, Galván-Femenía, Iván, Blay, Natalia, Carreras, Anna, Cortés, Beatriz, Farré, Xavier, Sumoy, Lauro, Moreno, Victor, Mercader, Josep Maria, Guindo-Martinez, Marta, Torrents, David, Kogevinas, Manolis, Garcia-Aymerich, Judith, Castaño-Vinyals, Gemma, Dobaño, Carlota, Renieri, Alessandra, Mari, Francesca, Fallerini, Chiara, Daga, Sergio, Benetti, Elisa, Baldassarri, Margherita, Fava, Francesca, Frullanti, Elisa, Valentino, Floriana, Doddato, Gabriella, Giliberti, Annarita, Tita, Rossella, Amitrano, Sara, Bruttini, Mirella, Croci, Susanna, Meloni, Ilaria, Mencarelli, Maria Antonietta, Lo Rizzo, Caterina, Pinto, Anna Maria, Beligni, Giada, Tommasi, Andrea, Di Sarno, Laura, Palmieri, Maria, Carriero, Miriam Lucia, Alaverdian, Diana, Busani, Stefano, Bruno, Raffaele, Vecchia, Marco, Belli, Mary Ann, Picchiotti, Nicola, Sanarico, Maurizio, Gori, Marco, Furini, Simone, Mantovani, Stefania, Ludovisi, Serena, Mondelli, Mario Umberto, Castelli, Francesco, Quiros-Roldan, Eugenia, Antoni, Melania Degli, Zanella, Isabella, Vaghi, Massimo, Rusconi, Stefano, Siano, Matteo, Montagnani, Francesca, Emiliozzi, Arianna, Fabbiani, Massimiliano, Rossetti, Barbara, Bargagli, Elena, Bergantini, Laura, D’Alessandro, Miriana, Cameli, Paolo, Bennett, David, Anedda, Federico, Marcantonio, Simona, Scolletta, Sabino, Franchi, Federico, Mazzei, Maria Antonietta, Guerrini, Susanna, Conticini, Edoardo, Cantarini, Luca, Frediani, Bruno, Tacconi, Danilo, Spertilli, Chiara, Feri, Marco, Donati, Alice, Scala, Raffaele, Guidelli, Luca, Spargi, Genni, Corridi, Marta, Nencioni, Cesira, Croci, Leonardo, Bandini, Maria, Caldarelli, Gian Piero, Piacentini, Paolo, Desanctis, Elena, Cappelli, Silvia, Canaccini, Anna, Verzuri, Agnese, Anemoli, Valentina, Ognibene, Agostino, Pancrazzi, Alessandro, Lorubbio, Maria, D’Arminio Monforte, Antonella, Miraglia, Federica Gaia, Girardis, Massimo, Venturelli, Sophie, Cossarizza, Andrea, Antinori, Andrea, Vergori, Alessandra, Gabrieli, Arianna, Riva, Agostino, Francisci, Daniela, Schiaroli, Elisabetta, Paciosi, Francesco, Scotton, Pier Giorgio, Andretta, Francesca, Panese, Sandro, Scaggiante, Renzo, Gatti, Francesca, Parisi, Saverio Giuseppe, Baratti, Stefano, Della Monica, Matteo, Piscopo, Carmelo, Capasso, Mario, Russo, Roberta, Andolfo, Immacolata, Iolascon, Achille, Fiorentino, Giuseppe, Carella, Massimo, Castori, Marco, Merla, Giuseppe, Squeo, Gabriella Maria, Aucella, Filippo, Raggi, Pamela, Marciano, Carmen, Perna, Rita, Bassetti, Matteo, Di Biagio, Antonio, Sanguinetti, Maurizio, Masucci, Luca, Valente, Serafina, Mandalà, Marco, Giorli, Alessia, Salerni, Lorenzo, Zucchi, Patrizia, Parravicini, Pierpaolo, Menatti, Elisabetta, Trotta, Tullio, Giannattasio, Ferdinando, Coiro, Gabriella, Lena, Fabio, Coviello, Domenico A., Mussini, Cristina, Martinelli, Enrico, Mancarella, Sandro, Tavecchia, Luisa, Crotti, Lia, Gabbi, Chiara, Rizzi, Marco, Maggiolo, Franco, Ripamonti, Diego, Bachetti, Tiziana, La Rovere, Maria Teresa, Sarzi-Braga, Simona, Bussotti, Maurizio, Ceri, Stefano, Pinoli, Pietro, Raimondi, Francesco, Biscarini, Filippo, Stella, Alessandra, Zguro, Kristina, Capitani, Katia, Suardi, Claudia, Dei, Simona, Parati, Gianfranco, Ravaglia, Sabrina, Artuso, Rosangela, Bottà, Giordano, Di Domenico, Paolo, Rancan, Ilaria, Francesco Bianchi, Antonio Perrella, Romani, Davide, Bergomi, Paola, Catena, Emanuele, Colombo, Riccardo, Tanfoni, Marco, Vincenti, Antonella, Ferri, Claudio, Grassi, Davide, Pessina, Gloria, Tumbarello, Mario, Di Pietro, Massimo, Sabrina, Ravaglia, Luchi, Sauro, Barbieri, Chiara, Acquilini, Donatella, Andreucci, Elena, Segala, Francesco Vladimiro, Tiseo, Giusy, Falcone, Marco, Lista, Mirjam, Poscente, Monica, De Vivo, Oreste, Petrocelli, Paola, Guarnaccia, Alessandra, Baroni, Silvia, Smith, Albert V., Boughton, Andrew P., Li, Kevin W., LeFaive, Jonathon, Annis, Aubrey, Justice, Anne E., Mirshahi, Tooraj, Chittoor, Geetha, Josyula, Navya Shilpa, Kosmicki, Jack A., Ferreira, Manuel A.R., Leader, Joseph B., Carey, Dave J., Gass, Matthew C., Horowitz, Julie E., Cantor, Michael N., Yadav, Ashish, Baras, Aris, Abecasis, Goncalo R., van Heel, David A., Hunt, Karen A., Mason, Dan, Huang, Qin Qin, Finer, Sarah, Genes & Health Research Team, Trivedi, Bhavi, Griffiths, Christopher J., Martin, Hilary C., Wright, John, Trembath, Richard C., Soranzo, Nicole, Zhao, Jing Hua, Butterworth, Adam S., Danesh, John, Di Angelantonio, Emanuele, Marike Boezen, Lude Franke, Deelen, Patrick, Claringbould, Annique, Lopera, Esteban, Warmerdam, Robert, Vonk, Judith.M., van Blokland, Irene, Lanting, Pauline, Ori, Anil P.S., Sebastian Zöllner, Brooke Wolford, Wang, Jiongming, Beck, Andrew, Peloso, Gina, Ho, Yuk-Lam, Sun, Yan V., Huffman, Jennifer E., O’Donnell, Christopher J., Cho, Kelly, Tsao, Phil, Gaziano, J. Michael, Nivard, Michel (M.G.), de geus, Eco (E.J.C.), Bartels, Meike, Hottenga, Jouke Jan, Weiss, Scott T., Karlson, Elizabeth W., Smoller, Jordan W., Green, Robert C., Anne Feng, Yen-Chen, Mercader, Josep, Murphy, Shawn N., Meigs, James B., Woolley, Ann E., Perez, Emma F., Rader, Daniel, Verma, Anurag, Ritchie, Marylyn D., Li, Binglan, Verma, Shefali S., Lucas, Anastasia, Bradford, Yuki, Zeberg, Hugo, Frithiof, Robert, Hultström, Michael, Lipcsey, Miklos, Nkambul, Lindo, Tardif, Nicolas, Rooyackers, Olav, Grip, Jonathan, Maricic, Tomislav, Karczewski, Konrad J., Atkinson, Elizabeth G., Tsuo, Kristin, Baya, Nikolas, Turley, Patrick, Gupta, Rahul, Callier, Shawneequa, Walters, Raymond K., Palmer, Duncan S., Sarma, Gopal, Cheng, Nathan, Lu, Wenhan, Bryant, Sam, Churchhouse, Claire, Cusick, Caroline, Goldstein, Jacqueline I., King, Daniel, Seed, Cotton, Finucane, Hilary, Martin, Alicia R., Satterstrom, F. Kyle, Wilson, Daniel J., Armstrong, Jacob, Rudkin, Justine K., Band, Gavin, Earle, Sarah G., Lin, Shang-Kuan, Arning, Nicolas, Crook, Derrick W., Wyllie, David H., O’Connell, Anne Marie, Spencer, Chris C.A., Koelling, Nils, Caulfield, Mark J., Scott, Richard H., Fowler, Tom, Moutsianas, Loukas, Kousathanas, Athanasios, Pasko, Dorota, Walker, Susan, Rendon, Augusto, Stuckey, Alex, Odhams, Christopher A., Rhodes, Daniel, Chan, Georgia, Arumugam, Prabhu, Ball, Catherine A., Hong, Eurie L., Rand, Kristin, Girshick, Ahna, Guturu, Harendra, Baltzell, Asher Haug, Roberts, Genevieve, Park, Danny, Coignet, Marie, McCurdy, Shannon, Knight, Spencer, Partha, Raghavendran, Rhead, Brooke, Zhang, Miao, Berkowitz, Nathan, Gaddis, Michael, Noto, Keith, Ruiz, Luong, Pavlovic, Milos, Sloofman, Laura G., Charney, Alexander W., Beckmann, Noam D., Schadt, Eric E., Jordan, Daniel M., Thompson, Ryan C., Gettler, Kyle, Abul-Husn, Noura S., Ascolillo, Steven, Buxbaum, Joseph D., Chaudhary, Kumardeep, Cho, Judy H., Itan, Yuval, Kenny, Eimear E., Belbin, Gillian M., Sealfon, Stuart C., Sebra, Robert P., Salib, Irene, Collins, Brett L., Levy, Tess, Britvan, Bari, Keller, Katherine, Tang, Lara, Peruggia, Michael, Hiester, Liam L., Niblo, Kristi, Aksentijevich, Alexandra, Labkowsky, Alexander, Karp, Avromie, Zlatopolsky, Menachem, Preuss, Michael, Loos, Ruth J.F., Nadkarni, Girish N., Do, Ron, Hoggart, Clive, Choi, Sam, Underwood, Slayton J., O’Reilly, Paul, Huckins, Laura M., Zyndorf, Marissa, D’Antonio, Matteo, Nguyen, Jennifer P., Arthur, Timothy D., Matsui, Hiroko, D’Antonio-Chronowska, Agnieszka, Frazer, Kelly A.

Publikováno v: In Cell Reports 16 November 2021 37(7)