Benzimidazole-based fluorophores for the detection of amyloid fibrils with higher sensitivity than Thioflavin-T.

Autor: Pravin N; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Kumar R; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Tripathi S; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Kumar P; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Mohite GM; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Navalkar A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Panigrahi R; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Singh N; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Gadhe LG; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Manchanda S; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Shimozawa M; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Nilsson P; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Johansson J; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Kumar A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Maji SK; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Shanmugam M; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.

Publikováno v: Journal of neurochemistry [J Neurochem] 2021 Mar; Vol. 156 (6), pp. 1003-1019. Date of Electronic Publication: 2020 Sep 09.

Parkinson's Disease Associated α-Synuclein Familial Mutants Promote Dopaminergic Neuronal Death in Drosophila melanogaster.

Autor: Mohite GM; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai 400076 , India., Dwivedi S; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai 400076 , India., Das S; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai 400076 , India.; IITB-Monash Research Academy , Indian Institute of Technology Bombay , Mumbai 400076 , India., Kumar R; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai 400076 , India., Paluri S; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai 400076 , India., Mehra S; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai 400076 , India., Ruhela N; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai 400076 , India., S A; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai 400076 , India., Jha NN; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai 400076 , India., Maji SK; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai 400076 , India.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2018 Nov 21; Vol. 9 (11), pp. 2628-2638. Date of Electronic Publication: 2018 Jul 03.

The Familial α-Synuclein A53E Mutation Enhances Cell Death in Response to Environmental Toxins Due to a Larger Population of Oligomers.

Autor: Mohite GM; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai , India 400076., Navalkar A; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai , India 400076., Kumar R; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai , India 400076., Mehra S; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai , India 400076., Das S; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai , India 400076.; IITB-Monash Research Academy , Indian Institute of Technology Bombay , Mumbai , India 400076., Gadhe LG; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai , India 400076., Ghosh D; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai , India 400076., Alias B; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai , India 400076., Chandrawanshi V; Department of Chemical Engineering , Indian Institute of Technology Bombay , Mumbai , India 400076., Ramakrishnan A; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai , India 400076., Mehra S; Department of Chemical Engineering , Indian Institute of Technology Bombay , Mumbai , India 400076., Maji SK; Department of Biosciences and Bioengineering , Indian Institute of Technology Bombay , Mumbai , India 400076.

Publikováno v: Biochemistry [Biochemistry] 2018 Aug 21; Vol. 57 (33), pp. 5014-5028. Date of Electronic Publication: 2018 Aug 06.

p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis.

Autor: Ghosh S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Salot S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Sengupta S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Navalkar A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Ghosh D; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Jacob R; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Das S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India.; IITB-Monash Research Academy, Indian Institute of Technology Bombay, Mumbai, India., Kumar R; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Jha NN; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Sahay S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Mehra S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Mohite GM; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Ghosh SK; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India., Kombrabail M; Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, India., Krishnamoorthy G; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India.; Department of Biotechnology, Anna University, Chennai, India., Chaudhari P; Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Navi Mumbai, India., Maji SK; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2017 Oct; Vol. 24 (10), pp. 1784-1798. Date of Electronic Publication: 2017 Jun 23.

Familial Parkinson disease-associated mutations alter the site-specific microenvironment and dynamics of α-synuclein.

Autor: Sahay S; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400 076, India and., Ghosh D; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400 076, India and., Dwivedi S; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400 076, India and., Anoop A; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400 076, India and., Mohite GM; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400 076, India and., Kombrabail M; Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400 005, India., Krishnamoorthy G; Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400 005, India gk@tifr.res.in., Maji SK; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400 076, India and samirmaji@iitb.ac.in.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2015 Mar 20; Vol. 290 (12), pp. 7804-22. Date of Electronic Publication: 2015 Jan 29.