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pro vyhledávání: '"Mohita J Mohan"'
Autor:
Theresa Seaton, Inder Patel, Justin Mitchell, Mohita J. Mohan, Mary Moyer, Marcos E. Milla, William Burkhart, J. David Becherer, Gregory M. Waitt, Marcia L. Moss, Anne Howe, Kevin Blackburn
Publikováno v:
Biochemistry. 41:9462-9469
TNF alpha converting enzyme (TACE) processes precursor TNF alpha between Ala76 and Val77, yielding a correctly processed bioactive 17 kDa protein. Genetic evidence indicates that TACE may also be involved in the shedding of other ectodomains. Here we
Autor:
Peiyuan Lin, C. Leann Hinkle, Mohita J Mohan, Fred Rasmussen, Marcos E Milla, Nolan Yeung, Marcia L Moss
Publikováno v:
Biochemistry. 42(7)
Shedding of TNF-alpha requires a single cleavage event, whereas the ectodomain of proTGF-alpha is cleaved at N-proximal (N-terminal) and membrane proximal (C-terminal) sites to release mature TGF-alpha. Tumor necrosis factor-alpha converting enzyme (
Publikováno v:
The EMBO journal. 19(17)
Many different growth factor ligands, including epidermal growth factor (EGF) and the neuregulins (NRGs), regulate members of the erbB/HER family of receptor tyrosine kinases. These growth factors induce erbB receptor oligomerization, and their biolo