Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Mohit Kapoor"'
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 3, Pp 100479- (2024)
Objective: Obesity is a leading risk factor for both the incidence and progression of osteoarthritis (OA). Omic technologies, including transcriptomics and metabolomics are capable of identifying RNA and metabolite profiles in tissues and biofluids o
Externí odkaz:
https://doaj.org/article/d78576ba3141443cbd77eec53dcdbaaf
Autor:
Yun Deng, Thomas A Perry, Philippa Hulley, Rose A Maciewicz, Joanna Mitchelmore, Darryl Perry, Staffan Larsson, Sophie Brachat, André Struglics, C Thomas Appleton, Stefan Kluzek, Nigel K Arden, David Felson, Brian Marsden, Brian D M Tom, Laura Bondi, Mohit Kapoor, Vicky Batchelor, Jennifer Mackay-Alderson, Vinod Kumar, L Stefan Lohmander, Tim J Welting, David A Walsh, Ana M Valdes, STEpUP OA Consortium, Tonia L Vincent, Fiona E Watt, Luke Jostins-Dean
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0309677 (2024)
ObjectivesTo develop a protocol for largescale analysis of synovial fluid proteins, for the identification of biological networks associated with subtypes of osteoarthritis.MethodsSynovial Fluid To detect molecular Endotypes by Unbiased Proteomics in
Externí odkaz:
https://doaj.org/article/1a7b992e033f487392bdc5e67be7b7f1
Autor:
Joshua Antunes, Ramés Salcedo-Jiménez, Starlee Lively, Pratibha Potla, Nathalie Coté, Marie-Soleil Dubois, Judith Koenig, Mohit Kapoor, Jonathan LaMarre, Thomas Gadegaard Koch
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297303 (2024)
Osteoarthritis (OA) is a leading cause of lameness in horses with no effective disease-modifying treatment and challenging early diagnosis. OA is considered a disease of the joint involving the articular cartilage, subchondral bone, synovial membrane
Externí odkaz:
https://doaj.org/article/c84e02d8789442449379633477327088
Autor:
Connor Walsh, Maneesha A. Rajora, Lili Ding, Sayaka Nakamura, Helal Endisha, Jason Rockel, Juan Chen, Mohit Kapoor, Gang Zheng
Publikováno v:
Chemical & Biomedical Imaging, Vol 1, Iss 1, Pp 66-80 (2023)
Despite the substantial burden posed by osteoarthritis (OA) globally, difficult challenges remain in achieving early OA diagnosis and adopting effective disease-modifying treatments. In this study, we use a biomolecular approach to address these limi
Externí odkaz:
https://doaj.org/article/a5757e3cb63a4e7a890b962a2db77a84
Autor:
Kirti Sharma, Manjinder Singh, Pratibha Sharma, Sumesh C. Sharma, Somdutt Mujwar, Mohit Kapoor, Krishna Kumar Mishra, Tanveer A. Wani
Publikováno v:
Molecules, Vol 29, Iss 6, p 1406 (2024)
SARS-CoV, an RNA virus, is contagious and displays a remarkable degree of adaptability, resulting in intricate disease presentations marked by frequent genetic mutations that can ultimately give rise to drug resistance. Targeting its viral replicatio
Externí odkaz:
https://doaj.org/article/2a42876fa0324a53a90033f23b733da0
Publikováno v:
Therapeutic Advances in Musculoskeletal Disease, Vol 15 (2023)
Osteoarthritis (OA) is the most common form of arthritis resulting in joint discomfort and disability, culminating in decline in life quality. Attention has been drawn in recent years to disease-associated molecular biomarkers found in readily access
Externí odkaz:
https://doaj.org/article/f44c785081de458ab59de0be0e5c0a12
Autor:
Shilpa Bhatia, Diemmy Nguyen, Laurel B. Darragh, Benjamin Van Court, Jaspreet Sharma, Michael W. Knitz, Miles Piper, Sanjana Bukkapatnam, Jacob Gadwa, Thomas E. Bickett, Shiv Bhuvane, Sophia Corbo, Brian Wu, Yichien Lee, Mayumi Fujita, Molishree Joshi, Lynn E. Heasley, Robert L. Ferris, Olga Rodriguez, Christopher Albanese, Mohit Kapoor, Elena B. Pasquale, Sana D. Karam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
EphrinB2 and its receptor EphB4 are highly expressed in head and neck squamous cell carcinoma (HNSCC) and disrupting EphB4-ephrinB2 interaction generates sub-optimal outcomes. Here, compartmental targeting of EphB4 and ephrinB2 in HNSCC cancer cell a
Externí odkaz:
https://doaj.org/article/f51f6287a90c4406bc2348a5db38a8b9
Autor:
Roman J. Krawetz, Yiru Elizabeth Wu, Karri L. Bertram, Anchita Shonak, Anand O. Masson, Guomin Ren, Catherine Leonard, Mohit Kapoor, John R. Matyas, Paul T. Salo
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-16 (2022)
Abstract Aggrecan is a critical component of the extracellular matrix of all cartilages. One of the early hallmarks of osteoarthritis (OA) is the loss of aggrecan from articular cartilage followed by degeneration of the tissue. Mesenchymal progenitor
Externí odkaz:
https://doaj.org/article/39a5e62d9d7a4f7d9e4e3ea507b01586
Autor:
Starlee Lively, Marie Milliot, Pratibha Potla, Osvaldo Espin-Garcia, Mehdi Layeghifard, Kala Sundararajan, Helal Endisha, Akihiro Nakamura, Anthony V. Perruccio, Christian Veillette, Mohit Kapoor, Y. Raja Rampersaud
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 4, Iss 3, Pp 100283- (2022)
Purpose: Up to 30% of spine facet osteoarthritis patients with lumbar spinal stenosis (SF-OA + LSS) have little to no improvement in their pain after surgery. Lack of meaningful improvement in pain following surgery provides a unique opportunit
Externí odkaz:
https://doaj.org/article/4de197ee90d8442d8c929c816a3f1b97
Autor:
Jason S. Rockel, Mehdi Layeghifard, Y. Raja Rampersaud, Anthony V. Perruccio, Nizar N. Mahomed, J. Roderick Davey, Khalid Syed, Rajiv Gandhi, Mohit Kapoor
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 4, Iss 3, Pp 100258- (2022)
Objective: Multiple disease phenotypes have been identified in knee osteoarthritis (OA) patients based on anthropometric, sociodemographic and clinical factors; however, differential systemic metabolite-based signatures in OA patients are not well un
Externí odkaz:
https://doaj.org/article/7e3b1b7d975b4898a3bf708078f3e3a7