Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mohini, Kalyan"'
Autor:
Alex J. Szubert, Katrina M. Pollock, Hannah M. Cheeseman, Jasmini Alagaratnam, Henry Bern, Olivia Bird, Marta Boffito, Ruth Byrne, Tom Cole, Catherine A. Cosgrove, Saul N. Faust, Sarah Fidler, Eva Galiza, Hana Hassanin, Mohini Kalyan, Vincenzo Libri, Leon R. McFarlane, Ana Milinkovic, Jessica O'Hara, David R. Owen, Daniel Owens, Mihaela Pacurar, Tommy Rampling, Simon Skene, Alan Winston, James Woolley, Yee Ting N. Yim, David T. Dunn, Sheena McCormack, Robin J. Shattock
Publikováno v:
EClinicalMedicine, Vol 56, Iss , Pp 101823- (2023)
Summary: Background: Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is well tolerated and immunogenic in SARS-CoV-2 seronegative and seropositive individuals aged 18–75. Methods: A phase 2a expanded safety and immunogenicity stud
Externí odkaz:
https://doaj.org/article/8c3e3b38ed0a4f79b89d74a152895c3b
Autor:
Tamara Elliott, Hannah M Cheeseman, Abbey B Evans, Suzanne Day, Leon R McFarlane, Jessica O'Hara, Mohini Kalyan, Fahimah Amini, Tom Cole, Alan Winston, Sarah Fidler, Katrina M Pollock, James A Harker, Robin J Shattock
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010885 (2022)
The optimal vaccination strategy to boost responses in the context of pre-existing immune memory to the SARS-CoV-2 spike (S) glycoprotein is an important question for global public health. To address this, we explored the SARS-CoV-2-specific humoral
Externí odkaz:
https://doaj.org/article/1a09b809d9a545c0a360c42067d12f43
Autor:
Stephanie Ascough, PhD, Pete Dayananda, MBChB, Mohini Kalyan, MSc, Seng Ung Kuong, MSc, Zoe Gardener, BSc, Emma Bergstrom, BSc, Suzanna Paterson, MbBChBAO, Satwik Kar, PhD, Vedika Avadhan, MRes, Ryan Thwaites, PhD, Ashley Sanchez Sevilla Uruchurtu, BSc, Tracy J Ruckwardt, PhD, Man Chen, MD, Deepika Nair, MS, Alexandrine Derrien-Colemyn, PhD, Barney S Graham, MD, Malcolm Begg, PhD, Edith Hessel, PhD, Peter Openshaw, ProfFMedSci, Christopher Chiu, ProfPhD
Publikováno v:
The Lancet. Healthy Longevity, Vol 3, Iss 6, Pp e405-e416 (2022)
Summary: Background: Respiratory viral infections are typically more severe in older adults. Older adults are more vulnerable to infection and do not respond effectively to vaccines due to a combination of immunosenescence, so-called inflamm-ageing,
Externí odkaz:
https://doaj.org/article/8d3c14033c20433d979206677c1a5568
Autor:
Katrina M. Pollock, Hannah M. Cheeseman, Alexander J. Szubert, Vincenzo Libri, Marta Boffito, David Owen, Henry Bern, Leon R. McFarlane, Jessica O'Hara, Nana-Marie Lemm, Paul McKay, Tommy Rampling, Yee Ting N. Yim, Ana Milinkovic, Cherry Kingsley, Tom Cole, Susanne Fagerbrink, Marites Aban, Maniola Tanaka, Savviz Mehdipour, Alexander Robbins, William Budd, Saul Faust, Hana Hassanin, Catherine A. Cosgrove, Alan Winston, Sarah Fidler, David Dunn, Sheena McCormack, Robin J. Shattock, Kirsty Adams, Fahimah Amini, Nafisah B Atako, Amalina Bakri, Wendy Barclay, Elizabeth Brodnicki, Jonathan C Brown, Ruth Byrne, Rowena Chilvers, Sofia Coelho, Suzanne Day, Monica Desai, Eleanor Dorman, Tamara Elliott, Katie E Flight, James Fletcher, John Galang, Jagruti Gohil, Aneta Gupta, Chris Harlow, Kai Hu, Mohini Kalyan, Dominic Lagrue, Ely Liscano, Cecilia Njenga, Krunal Polra, Derecia A Powlette, Paul Randell, Mary Rauchenberger, Ianto Redknap, Maravic Ricamara, Paul Rogers, Hadijatou Sallah, Karnyart Samnuan, Michael Schumacher, Zareena Shah, Rachel Shaw, Thomas Shaw, Stefan Sivapatham, Susie Slater, Kim Sorley, Regina Storch, Elizabeth Tan, Tricia Tan, Lieze Thielemans, Sarah Whitely, Charlotte Valentine, Jeeva Varghese, Asha Vikraman, Martin Wilkins
Publikováno v:
EClinicalMedicine, Vol 44, Iss, Pp 101262-(2022)
EClinicalMedicine
EClinicalMedicine
Summary: Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is a novel technology formulated as a low dose vaccine against COVID-19. Methods: A phase I first-in-human dose-ranging trial of a saRNA COVID-19 vaccine candidate LNP-nCoVsaR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28acc41920bce70d4d6595fa69b972ce
https://eprints.soton.ac.uk/455190/
https://eprints.soton.ac.uk/455190/
Autor:
John Sidney, Jie Zhu, Emma Bergstrom, Sebastian L. Johnston, Agnieszka Jozwik, Allan Paras, Jerico Del Rosario, Peter J. M. Openshaw, Christopher Chiu, Onn Min Kon, Mohini Kalyan, Aleks Guvenel, Ernie Wong, Satwik Kar, Suzanna Paterson, Patrick Mallia, Annemarie Sykes, Zoe Gardener, Maximillian S. Habibi, Alessandro Sette, Mark H. Almond, Mirae Park, Bjoern Peters, Jaideep Dhariwal, Stephanie Ascough, Seng Kuong Ung, Maria-Belen Trujillo-Torralbo
Publikováno v:
The Journal of Clinical Investigation
Guvenel, A, Jozwik, A, Ascough, S, Ung, S K, Paterson, S, Kalyan, M, Gardener, Z, Bergstrom, E, Kar, S, Habibi, M S, Paras, A, Zhu, J, Park, M, Dhariwal, J, Almond, M, Wong, E H C, Sykes, A, Del Rosario, J, Trujillo-torralbo, M, Mallia, P, Sidney, J, Peters, B, Kon, O M, Sette, A, Johnston, S L, Openshaw, P J & Chiu, C 2019, ' Epitope-specific airway-resident CD4 + T cell dynamics during experimental human RSV infection ', Journal of Clinical Investigation, vol. 130, no. 1, pp. 523-538 . https://doi.org/10.1172/JCI131696
Guvenel, A, Jozwik, A, Ascough, S, Ung, S K, Paterson, S, Kalyan, M, Gardener, Z, Bergstrom, E, Kar, S, Habibi, M S, Paras, A, Zhu, J, Park, M, Dhariwal, J, Almond, M, Wong, E H C, Sykes, A, Del Rosario, J, Trujillo-torralbo, M, Mallia, P, Sidney, J, Peters, B, Kon, O M, Sette, A, Johnston, S L, Openshaw, P J & Chiu, C 2019, ' Epitope-specific airway-resident CD4 + T cell dynamics during experimental human RSV infection ', Journal of Clinical Investigation, vol. 130, no. 1, pp. 523-538 . https://doi.org/10.1172/JCI131696
BACKGROUND. Respiratory syncytial virus (RSV) is an important cause of acute pulmonary disease and one of the last remaining major infections of childhood for which there is no vaccine. CD4+ T cells play a key role in antiviral immunity, but they hav
Autor:
Margriet Dijkstra-Tiekstra, Peter J. M. Openshaw, Mohini Kalyan, Maarten L. van Roosmalen, Roberto Grimaldi, Christopher Chiu, Bert-Jan Haijema, Kees Leenhouts, Qibo Zhang, Muhammad S Ahmed, Iris T. Vlachantoni, Sanna Wallin-Weber, Stephanie Ascough
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
RATIONALE:Needle-free intranasal vaccines offer major potential advantages, especially against pathogens entering via mucosal surfaces. As yet, there is no effective vaccine against respiratory syncytial virus (RSV), a ubiquitous pathogen of global i
Autor:
Christopher W. Woods, Zoe Gardener, Onn Min Kon, Agnieszka Jozwik, Peter J. M. Openshaw, Bradly P. Nicholson, Patrick Mallia, Satwik Kar, Suzanna Paterson, Jeroen Maertzdorf, Mohini Kalyan, Hans-Joachim Mollenkopf, Hannah Jarvis, January Weiner, Seng Kuong Ung, Akhilesh Jha, Stefan H. E. Kaufmann, Timothy Veldman, Joanna Zyla, Stephanie Ascough, Emma Bergstrom, Christopher Chiu
Publikováno v:
Am J Respir Crit Care Med
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
Rationale: Suboptimal vaccine immunogenicity and antigenic mismatch, compounded by poor uptake, means that influenza remains a major global disease. T cells recognizing peptides derived from conserved viral proteins could enhance vaccine-induced cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b7f8274beb78131939c09ac3102551
https://europepmc.org/articles/PMC8528532/
https://europepmc.org/articles/PMC8528532/
Autor:
Philippa J, Goddard, Julia, Sanchez-Garrido, Sabrina L, Slater, Mohini, Kalyan, David, Ruano-Gallego, Olivier, Marchès, Luis Ángel, Fernández, Gad, Frankel, Avinash R, Shenoy
Publikováno v:
Cell reports. 27(4)
Microbial infections can stimulate the assembly of inflammasomes, which activate caspase-1. The gastrointestinal pathogen enteropathogenic Escherichia coli (EPEC) causes localized actin polymerization in host cells. Actin polymerization requires the