Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mohinder S. Bathala"'
Autor:
Jeanne Mendell, Hiroshi Masumoto, Mohinder S. Bathala, Toshihiro Oguma, Ling He, Chris Lowrie
Publikováno v:
Drug Metabolism and Disposition. 40:2250-2255
This study determined the mass balance and pharmacokinetics of edoxaban in humans after oral administration of [¹⁴C]edoxaban. After oral administration of 60 mg (as active moiety) of [¹⁴C]edoxaban to six healthy male subjects, serial blood/plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a89b93550946ef53f9eb8d8391a1c2
https://doi.org/10.1124/dmd.112.046888
https://doi.org/10.1124/dmd.112.046888
Autor:
Vaishali P Sahasrabudhe, Hemant N. Joshi, Mohinder S Bathala, Abu T.M. Serajuddin, Varia Sailesh Amilal, Ravindra W. Tejwani, Mohammed Jemal, Martha Davidovich
Publikováno v:
International Journal of Pharmaceutics. 269:251-258
Oral bioavailability of a poorly water-soluble drug was greatly enhanced by using its solid dispersion in a surface-active carrier. The weakly basic drug (pK(a) approximately 5.5) had the highest solubility of 0.1mg/ml at pH 1.5, < 1 microg/ml aqueou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19e936cb950f289424169948a6ea440
https://doi.org/10.1016/j.ijpharm.2003.09.002
https://doi.org/10.1016/j.ijpharm.2003.09.002
Autor:
Raymond B. Darbenzio, Gary J. Grover, Albert J. D'Alonzo, Thomas A. Hess, Charles S. Parham, Mohinder S. Bathala
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:132-140
Recent studies have shown the importance of mitochondrial ATP-sensitive potassium channels (K ATP ) in cardioprotection, and studies in vitro have shown that the benzopyran analog (3 R )- trans - 4-((4-chlorophenyl)- N -(1 H -imidazol-2-ylmethyl)dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c666ad0e7d55c0a2bed6ea6578530b7
https://doi.org/10.1124/jpet.102.036988
https://doi.org/10.1124/jpet.102.036988
Autor:
Fraser Pickersgill, Mohinder S. Bathala, Hideo Takakusa, Daisuke Nakai, Mark A. Ashwell, Takashi Izumi, Tomoko Kimura, Ronald E. Savage, Taro Tokui, Emi Kamiyama, Jimbo Takeshi, Tomoe Taira, Takahiro Murai, Hamim Zahir
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 44(11)
1. The biotransformation and disposition of tivantinib in humans, dogs and rats was examined after a single oral administration of [(14)C]tivantinib. Tivantinib constituted no more than one-third of the plasma radioactivity in all species, demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cccbc2eafa83ceaf00dedfc1b66fba
https://pubmed.ncbi.nlm.nih.gov/24911380
https://pubmed.ncbi.nlm.nih.gov/24911380
Autor:
Mark Allison, Daniel E. Salazar, Magdy Shenouda, Shashank Rohatagi, Robert J. Noveck, Stephen Haworth, Igor Rubets, Mohinder S. Bathala, Reinilde Heyrman, James Lee
Publikováno v:
Journal of clinical pharmacology. 48(11)
The pharmacokinetics of amlodipine and olmesartan in healthy volunteers after coadministration of amlodipine besylate and olmesartan medoxomil concomitantly as separate dosage forms and together in a fixed-dose combination tablet were characterized i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab94739b3c2e1dd288f3f1ee03a8228
https://pubmed.ncbi.nlm.nih.gov/18974285
https://pubmed.ncbi.nlm.nih.gov/18974285
Autor:
Fraser Pickersgill, Takahiro Murai, Hamim Zahir, Mohinder S. Bathala, Taro Tokui, Daisuke Nakai
Publikováno v:
Cancer Research. 72:747-747
Background: Tivantinib (ARQ 197), a selective, oral, non-ATP-competitive, small-molecule inhibitor of c-MET receptor tyrosine kinase, is being evaluated in combination with other agents in non-small cell lung cancer, colorectal cancer, and hepatocell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd68662ed770d9adbe5ee8b136c1ec37
https://doi.org/10.1158/1538-7445.am2012-747
https://doi.org/10.1158/1538-7445.am2012-747
Autor:
Ling He, Minoru Uchiyama, Haruo Iwabuchi, Takashi Izumi, Fraser Pickersgill, Taro Tokui, Hamim Zahir, Hiroko Koda, Mohinder S. Bathala, Kumiko Koyama
Publikováno v:
Cancer Research. 71:1311-1311
Background: CS-7017 is a novel, oral, highly potent and selective peroxisome proliferator-activated receptor gamma agonist with demonstrated anticancer activity in preclinical models. Currently, CS-7017 is in phase 2 trials for the treatment of non-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e633ca7801c83fe1e56438ee28fbdc0d
https://doi.org/10.1158/1538-7445.am2011-1311
https://doi.org/10.1158/1538-7445.am2011-1311
Publisher Summary Spectropolarimetry encompasses the complementary chiroptical techniques of optical rotatory dispersion (ORD) and circular dichroism (CD) and a more recent method, magnetic circular dichroism (MCD). With antibiotics, the spectra are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1fbafa4c42a571e3d92d4cb3a63ac3c
https://doi.org/10.1016/0076-6879(75)43093-2
https://doi.org/10.1016/0076-6879(75)43093-2
Publikováno v:
Chemischer Informationsdienst. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77334694604d8ad30f7acce6acb67c56
https://doi.org/10.1002/chin.197521482
https://doi.org/10.1002/chin.197521482
Publikováno v:
HETEROCYCLES. 3:7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59ee050665a10958ecd043b4e41a14a3
https://doi.org/10.3987/r-1975-01-0007
https://doi.org/10.3987/r-1975-01-0007