Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Mohd Waseem Akhtar"'
Autor:
Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela, Alejandro Amador-Arjona, Vivek Swarup, James Parker, Jeffrey D. Zaremba, Timothy Holland, Neha Bansal, Daniel R. Holohan, Kevin Lopez, Scott D. Ryan, Shing Fai Chan, Li Yan, Xiaofei Zhang, Xiayu Huang, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Huaxi Xu, Yuqiang Wang, Daniel H. Geschwind, Amanda J. Roberts, Alexey V. Terskikh, Robert A. Rissman, Eliezer Masliah, Stuart A. Lipton, Nobuki Nakanishi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Human MEF2C haploinsufficiency results in Autism Spectrum Disorder (ASD), but it is unclear if the same is true in mice. Here, the authors show that Mef2c +/− mice have behavioral defects and neuronal abnormalities similar to ASD, and symptoms can
Externí odkaz:
https://doaj.org/article/386d48d4311a447bb8bff05a85d294e7
Autor:
Mohd Waseem Akhtar, Sara Sanz-Blasco, Nima Dolatabadi, James Parker, Kevin Chon, Michelle S. Lee, Walid Soussou, Scott R. McKercher, Rajesh Ambasudhan, Tomohiro Nakamura, Stuart A. Lipton
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberra
Externí odkaz:
https://doaj.org/article/9fb0c0af61564f9ba2f975e9d457f235
Autor:
Tomohiro Nakamura, Olga A. Prikhodko, Elaine Pirie, Saumya Nagar, Mohd Waseem Akhtar, Chang-Ki Oh, Scott R. McKercher, Rajesh Ambasudhan, Shu-ichi Okamoto, Stuart A. Lipton
Publikováno v:
Neurobiology of Disease, Vol 84, Iss , Pp 99-108 (2015)
Nitric oxide (NO) is a gasotransmitter that impacts fundamental aspects of neuronal function in large measure through S-nitrosylation, a redox reaction that occurs on regulatory cysteine thiol groups. For instance, S-nitrosylation regulates enzymatic
Externí odkaz:
https://doaj.org/article/f1f59b9dd3d54f7b9aa8622cf6a1bca9
Autor:
Swagata Ghatak, Maria Talantova, Sara Sanz-Blasco, Mohd Waseem Akhtar, Jeffery W. Kelly, Stuart A. Lipton, William P. Lynch, Dorit Trudler, Juan C. Piña-Crespo, Karthik Bodhinathan, Yvonne S. Eisele
Publikováno v:
J Neurosci
Synaptic and neuronal loss are major neuropathological characteristics of Parkinson's disease. Misfolded protein aggregates in the form of Lewy bodies, comprised mainly of α-synuclein (αSyn), are associated with disease progression, and have also b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d04f7556e99abdc9d37a9b1cbb4a39
https://pubmed.ncbi.nlm.nih.gov/33483428
https://pubmed.ncbi.nlm.nih.gov/33483428
Publikováno v:
International Journal of Cell Biology, Vol 2012 (2012)
Debilitating neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), can be attributed to neuronal cell damage in specific brain regions. An important hallmark of these diseases is increased oxidative and nitrosativ
Externí odkaz:
https://doaj.org/article/ba21da5fd52a4d899d83ce395ee32911
Autor:
Walid Soussou, Stuart A. Lipton, Scott R. McKercher, Sara Sanz-Blasco, Nima Dolatabadi, Mohd Waseem Akhtar, Rajesh Ambasudhan, Michelle S. Lee, James C. Parker, Tomohiro Nakamura, Kevin Chon
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature communications, vol 7, iss 1
Nature Communications
Nature communications, vol 7, iss 1
Nature Communications
Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer's disease (AD). The molecular mechanism for this association remains poorly defined. Here we report in human and rodent tissues that elevated glucose, as found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44636981518c2dc81fc14768a0bb6a3
https://doaj.org/article/9fb0c0af61564f9ba2f975e9d457f235
https://doaj.org/article/9fb0c0af61564f9ba2f975e9d457f235
Autor:
Scott R. McKercher, Tomohiro Nakamura, Rajesh Ambasudhan, Saumya Nagar, Stuart A. Lipton, Shu-ichi Okamoto, Elaine Pirie, Olga Prikhodko, Chang-ki Oh, Mohd Waseem Akhtar
Publikováno v:
Neurobiology of Disease, Vol 84, Iss, Pp 99-108 (2015)
Nitric oxide (NO) is a gasotransmitter that impacts fundamental aspects of neuronal function in large measure through S-nitrosylation, a redox reaction that occurs on regulatory cysteine thiol groups. For instance, S-nitrosylation regulates enzymatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d07176366496027daccd3c47cd226d
https://doi.org/10.1016/j.nbd.2015.03.017
https://doi.org/10.1016/j.nbd.2015.03.017
Autor:
Timothy Holland, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Eliezer Masliah, Yuqiang Wang, Alexey V. Terskikh, Vivek Swarup, Huaxi Xu, Xiayu Huang, Mohd Waseem Akhtar, Daniel H. Geschwind, James C. Parker, Scott D. Ryan, Amanda J. Roberts, Shichun Tu, Rosa Maria Escorihuela, Xiaofei Zhang, Nobuki Nakanishi, Neha Bansal, Alejandro Amador-Arjona, Stuart A. Lipton, Shing Fai Chan, Li Yan, Kevin M. Lopez, Robert A. Rissman, Jeffrey D. Zaremba, Daniel R. Holohan
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tu, Shichun; Akhtar, Mohd Waseem; Escorihuela, Rosa Maria; Amador-Arjona, Alejandro; Swarup, Vivek; Parker, James; et al.(2017). NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.. Nature communications, 8(1), 1488. doi: 10.1038/s41467-017-01563-8. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5127z2zd
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tu, Shichun; Akhtar, Mohd Waseem; Escorihuela, Rosa Maria; Amador-Arjona, Alejandro; Swarup, Vivek; Parker, James; et al.(2017). NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.. Nature communications, 8(1), 1488. doi: 10.1038/s41467-017-01563-8. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5127z2zd
Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD), and human MEF2C haploinsufficiency results in ASD, intellectual disability, and epilepsy. However, molecular mechanisms underlying MEF2C haploinsufficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a166fd27dec67afce13c21feb0e1119
http://europepmc.org/articles/PMC5684358
http://europepmc.org/articles/PMC5684358
Autor:
Scott R. McKercher, Nobuki Nakanishi, Mohd Waseem Akhtar, Stuart A. Lipton, Laurence M. Brill, Shing Fai Chan, Shu-ichi Okamoto, Rameez Zaidi, Samuel Sances
Publikováno v:
The Journal of Neuroscience. 34:4640-4653
Mutations in the ataxia telangiectasia mutated (ATM) gene, which encodes a kinase critical for the normal DNA damage response, cause the neurodegenerative disorder ataxia-telangiectasia (AT). The substrates of ATM in the brain are poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9f8c58b5bedfe12bcb720261af0724
https://doi.org/10.1523/jneurosci.2510-12.2014
https://doi.org/10.1523/jneurosci.2510-12.2014
Publikováno v:
International Journal of Cell Biology
International Journal of Cell Biology, Vol 2012 (2012)
International Journal of Cell Biology, Vol 2012 (2012)
Debilitating neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), can be attributed to neuronal cell damage in specific brain regions. An important hallmark of these diseases is increased oxidative and nitrosativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6675cf825caf98d57887de16c9bb33
https://doi.org/10.1155/2012/463756
https://doi.org/10.1155/2012/463756