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Bone Marrow Stroma Influences Transforming Growth Factor-β Production in Breast Cancer Cells to Regulate c-myc Activation of the Preprotachykinin-I Gene in Breast Cancer Cells

Autor: Jason C. Livingston, Ian P. Whitehead, Prem S. Patel, Anabella L. Moharita, Hyun S. Oh, Joseph G. Potian, Tammy Castro, Pranela Rameshwar

Publikováno v: Cancer Research. 64:6327-6336

Breast cancer cells (BCCs) have preference for the bone marrow (BM). This study used an in vitro coculture of BCCs and BM stroma to represent a model of early breast cancer metastasis to the BM. The overarching hypothesis states that once BCCs are in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6888a1254e82bf2f643c6fa24698d442
https://doi.org/10.1158/0008-5472.can-03-3122

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SDF-1alpha regulation in breast cancer cells contacting bone marrow stroma is critical for normal hematopoiesis

Autor: Kelly E. Corcoran, Pranela Rameshwar, Prem S. Patel, Anabella L. Moharita, Margarette Bryan, Marcelo Taborga

Publikováno v: Blood. 108(10)

Breast cancer cells (BCCs) show preference for the bone marrow (BM). An animal model showed 2 populations of BCCs in the BM with regard to their cycling states. An in vitro model of early BC entry into BM showed normal hematopoiesis. Here, we show a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65dc6228390c4e2150b5dc18899fbe99
https://pubmed.ncbi.nlm.nih.gov/16857992

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The anti-proliferative effect of neurokinin-A on hematopoietic progenitor cells is partly mediated by p53 activating the 5' flanking region of neurokinin-2 receptor

Autor: Hiral Patel, Suvarnamala Vishalakumar, Anabella L. Moharita, Jonathan S. Harrison, Pranela Rameshwar

Publikováno v: Cellular signalling. 18(4)

The bone marrow (BM) is home to at least two stem cells, hematopoietic (HSC) and mesenchymal. Hematopoiesis is partly regulated through neurokinin-1 (NK-1) and NK-2 belonging to the family of G-protein/7-transmembrane receptors. NK-1 and NK-2 show pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7d78634a2d3b5abce0ec9a63c88e91
https://pubmed.ncbi.nlm.nih.gov/16009534

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