Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mohanram Sivaraja"'
Autor:
Mohanram Sivaraja, Nicola Pozzi, Matthew Rienzo, Kenneth Lin, Timothy P Shiau, Daniel M Clemens, Lev Igoudin, Piotr Zalicki, Stephanie S Chang, M Angels Estiarte, Kevin M Short, David C Williams, Anirban Datta, Enrico Di Cera, David B Kita
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201377 (2018)
INTRODUCTION:In recent years, the traditional treatments for thrombotic diseases, heparin and warfarin, are increasingly being replaced by novel oral anticoagulants offering convenient dosing regimens, more predictable anticoagulant responses, and le
Externí odkaz:
https://doaj.org/article/f610424ff315488398aaec24e248f870
Autor:
Mohanram Sivaraja, David Ben Kita, Chengpei Xu, Sivan Sizikov, Lev Igoudin, M. Angels Estiarte, Nicola Pozzi, Bo Yang, Timothy Shiau, Matthew Rienzo, Keith A.A. Fox, Subhadra Dash, Madhuri Chattopadhyay, David C. Williams, Enrico Di Cera, Samuel Keutzer, Kevin Michael Short, C. Michael Gibson, Daniel M. Clemens, Molly Ryan, Stephanie S Chang, Anirban Datta, Piotr Zalicki
Publikováno v:
Thromb Res
Introduction High incidence of bleeding events remains a key risk for patients taking anticoagulants, especially those in need of long-term combination therapy with antiplatelet agents. As a consequence, patients may not receive clinically indicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfcde35aa8b5506a1bf9172d5b5935fb
https://pubmed.ncbi.nlm.nih.gov/32339947
https://pubmed.ncbi.nlm.nih.gov/32339947
Autor:
Lev Igoudin, Stephanie H. Chang, Angels Estiarte, David Ben Kita, Anirban Datta, Sivan Sizikov, Timothy Shiau, Tamari Kirtadze, Mohanram Sivaraja, David J. Williams, Chengpei Xu, Daniel M. Clemens, Bo Yang, Kevin Michael Short, Madhuri Chattopadhyay
Publikováno v:
Stroke. 50
Introduction: Anticoagulants, while an effective prophylactic for ischemic stroke increase a patient’s risk of major bleeding. There is currently an unmet need for new anticoagulants with the ideal combination of efficacy and low bleeding risk. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b159186827a34f52806e581ba896fda
https://doi.org/10.1161/str.50.suppl_1.tmp98
https://doi.org/10.1161/str.50.suppl_1.tmp98
Autor:
Lev Igoudin, David C. Williams, David Ben Kita, Mohanram Sivaraja, Kevin Michael Short, Timothy Shiau, M. Angels Estiarte, Enrico Di Cera, Nicola Pozzi, Kenneth Lin, Daniel M. Clemens, Anirban Datta, Piotr Zalicki, Matthew Rienzo, Stephanie S Chang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 8, p e0201377 (2018)
PLoS ONE, Vol 13, Iss 8, p e0201377 (2018)
Introduction In recent years, the traditional treatments for thrombotic diseases, heparin and warfarin, are increasingly being replaced by novel oral anticoagulants offering convenient dosing regimens, more predictable anticoagulant responses, and le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7465ca24a6d130e0c0727311d9db353
https://pubmed.ncbi.nlm.nih.gov/30071045
https://pubmed.ncbi.nlm.nih.gov/30071045
Autor:
Shirley Q. Feng, Lily W. Hu, Hanbiao Yang, Mohanram Sivaraja, Russell Johnson, Robert S. McDowell, Haiying Cai, Julie Lai, Yuko Kosaka, Marc J. Evanchik, Cristiana A. Zaharia, Johan D. Oslob, Samnang Tep
Publikováno v:
ACS Medicinal Chemistry Letters. 4:113-117
Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochemical activities. The most potent analogue (compound 19) also inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfbfcaac97a11e0feb783bd78931ba6
https://doi.org/10.1021/ml300335r
https://doi.org/10.1021/ml300335r
Autor:
Jennifer E. Huyett, Mohanram Sivaraja, Brian M. Hoffman, David B. Goodin, Andrew L. P. Houseman, Peter E. Doan, Ryszard J. Gurbiel
Publikováno v:
Journal of the American Chemical Society. 117:9033-9041
The fully oxidized state of cytochrome c peroxidase (CcP), called ES, contains two oxidizing equivalents, one as an oxyferryl heme and the other as an organic radical on an amino acid residue. The unusual electron paramagnetic resonance spectrum of E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c2ce26d133686563e3afc2d1b2c63e
https://doi.org/10.1021/ja00140a021
https://doi.org/10.1021/ja00140a021
Autor:
Patrick J. Hu, Mohanram Sivaraja, Kevin P. Williams, Steven E. Shoelson, Michael A. Weiss, Joseph Schlessinger
Publikováno v:
The EMBO Journal. 12:795-802
SH2 (src-homology 2) domains define a newly recognized binding motif that mediates the physical association of target phosphotyrosyl proteins with downstream effector enzymes. An example of such phosphoprotein-effector coupling is provided by the ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8739aa8af477a02aa7d3d5d4bc7233d
https://doi.org/10.1002/j.1460-2075.1993.tb05714.x
https://doi.org/10.1002/j.1460-2075.1993.tb05714.x
Autor:
G. Charles Dismukes, Mohanram Sivaraja
Publikováno v:
Biochemistry. 27:6297-6306
The reaction of hydroxylamine, a substrate analogue of the water-oxidizing complex (WOC), with spinach photosystem II (PSII) membranes has been further studied by using EPR spectroscopy to monitor the stepwise oxidation of donors and reduction of ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b32f50cb97267476d921bcad2065da2e
https://doi.org/10.1021/bi00417a015
https://doi.org/10.1021/bi00417a015
Autor:
James A. Fee, Mohanram Sivaraja, David P. Ballou, Christopher J. Batie, Ryszard J. Gurbiel, Brian M. Hoffman, Anne E. True
Publikováno v:
Biochemistry. 28:4861-4871
We have performed ENDOR spectroscopy at microwave frequencies of 9 and 35 GHz at 2 K on the reduced Rieske-type (2Fe-2S) cluster of phthalate dioxygenase (PDO) from Pseudomonas cepacia. Four samples have been examined: (1) 14N (natural abundance); (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f52cdb91d2d94ffec338b60140f89c0
https://doi.org/10.1021/bi00437a051
https://doi.org/10.1021/bi00437a051
Publikováno v:
Science. 245:738-740
The chemical identity of the amino acid free-radical site that represents one of the two oxidizing equivalents stored in the H2O2-oxidized intermediate (compound ES) of the mitochondrial heme enzyme, cytochrome c peroxidase (CcP) has been sought for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d5c38d3ca10f0000eebf64811c2bb6
https://doi.org/10.1126/science.2549632
https://doi.org/10.1126/science.2549632