Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mohani N, Sukhdeo"'
Autor:
Lee D. Jennings, Derek C. Cole, Joseph R. Stock, Mohani N. Sukhdeo, John W. Ellingboe, Rebecca Cowling, Guixian Jin, Eric S. Manas, Kristi Y. Fan, Michael S. Malamas, Boyd L. Harrison, Steve Jacobsen, Rajiv Chopra, Peter A. Lohse, William J. Moore, Mary-Margaret O’Donnell, Yun Hu, Albert J. Robichaud, M. James Turner, Erik Wagner, Jonathan Bard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:767-771
Autor:
M. James Turner, Lee D. Jennings, Ann Aulabaugh, Derek Cecil Cole, E.S. Manas, Mohani N. Sukhdeo, Steve Jacobsen, Joseph Raymond Stock, Laura Lin, James Strand, Junjun Wu, Mark L. Stahl, John W. Ellingboe, Guixan Jin, and Ping Zhou, Kristi Fan, Boyd L. Harrison, Rajiv Chopra, Kristine Svenson, Frank E. Lovering, Yun Hu, Erik Wagner, Jeffrey Scott Condon, Rebecca Cowling, Michael S. Malamas, Jonathan A. Bard
Publikováno v:
Journal of Medicinal Chemistry. 49:6158-6161
BACE1 is an aspartyl protease responsible for cleaving amyloid precursor protein to liberate Abeta, which aggregates leading to plaque deposits implicated in Alzheimer's disease. We have identified small-molecule acylguanidine inhibitors of BACE1. Cr
Autor:
Lee D, Jennings, Kenneth W, Foreman, Thomas S, Rush, Desiree H H, Tsao, Lidia, Mosyak, Scott L, Kincaid, Mohani N, Sukhdeo, Alan G, Sutherland, Weidong, Ding, Cynthia Hess, Kenny, Chantel L, Sabus, Hanlan, Liu, Elizabeth G, Dushin, Soraya L, Moghazeh, Pornpen, Labthavikul, Peter J, Petersen, Margareta, Tuckman, Steven A, Haney, Alexey V, Ruzin
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5115-5131
The ZipA–FtsZ protein–protein interaction is a potential target for antibacterial therapy. The design and parallel synthesis of a combinatorial library of small molecules, which target the FtsZ binding area on ZipA are described. Compounds were d
Autor:
Lee D, Jennings, Derek C, Cole, Joseph R, Stock, Mohani N, Sukhdeo, John W, Ellingboe, Rebecca, Cowling, Guixian, Jin, Eric S, Manas, Kristi Y, Fan, Michael S, Malamas, Boyd L, Harrison, Steve, Jacobsen, Rajiv, Chopra, Peter A, Lohse, William J, Moore, Mary-Margaret, O'Donnell, Yun, Hu, Albert J, Robichaud, M James, Turner, Erik, Wagner, Jonathan, Bard
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(2)
The proteolytic enzyme beta-secretase (BACE-1) produces amyloid beta (Abeta) peptide, the primary constituent of neurofibrillary plaques, implicated in Alzheimer's disease, by cleavage of the amyloid precursor protein. A small molecule inhibitor of B
Autor:
Alexey Ruzin, Peter Petersen, Lidia Mosyak, Mohani N. Sukhdeo, Thomas S. Rush, Margareta Tuckman, Lee D. Jennings, Elizabeth G. Dushin, Soraya L. Moghazeh, Alan G. Sutherland, Yuanhong Li, Ken W. Foreman, Cynthia Hess Kenny, Desiree H.H. Tsao, Weidong Ding
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(6)
The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ
Autor:
Steven A. Haney, Soraya L. Moghazeh, Thomas S. Rush, Pornpen Labthavikul, Margareta Tuckman, Peter Petersen, Lidia Mosyak, Lee D. Jennings, Mohani N. Sukhdeo, Weidong Ding, Alexey Ruzin, Hanlan Liu, Desiree H.H. Tsao, Scott L. Kincaid, Alan G. Sutherland, Cynthia Hess Kenny, Elizabeth G. Dushin, Chantel L. Sabus, Kenneth Foreman
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:5884