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Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells

Autor: Mohanam, S., Jasti, S. L., Kondraganti, S. R., Chandrasekar, N., Lakka, S. S., Kin, Y., Fuller, G. N., Yung, A. W., Kyritsis, A. P., Dinh, D. H., Olivero, W. C., Gujrati, M., Ali-Osman, F., Rao, J. S.

Increases in abundance of cathepsin B transcript and protein correlate with increases in tumor grade and alterations in subcellular localization and activity of cathepsin B. The enzyme is able to degrade the components of the extracellular matrix (EC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::e45d67509b11335588d4cfb13f91d707
http://olympias.lib.uoi.gr/jspui/handle/123456789/22341

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RETRACTED: Down-regulation of integrin alpha(v)beta(3) expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes (Retracted article. See vol. 295, pg. 13134, 2020)

Autor: Adachi, Y Lakka, SS Chandrasekar, N Yanamandra, N Gondi, CS Mohanam, S Dinh, DH Olivero, WC Gujrati, M and Tamiya, T Ohmoto, T Kouraklis, G Aggarwal, B Rao, JS

Interaction between the extracellular matrix and integrin receptors on cell surfaces leads not only to cell adhesion but also to intracellular signaling events that affect cell migration, proliferation, and survival. The vitronectin receptor alpha (v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::35c6402a68fc159576b4b1ca0503d7ab
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3081069

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Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion

Autor: Kondraganti, S., Mohanam, S., Chintala, S. K., Kin, Y., Jasti, S. L., Nirmala, C., Lakka, S. S., Adachi, Y., Kyritsis, A. P., Ali-Osman, F., Sawaya, R., Gregory Fuller, Rao, J. S.

Publikováno v: Scopus-Elsevier

Increased expression of matrix metalloproteinases (MMPs) has been associated with human glioblastoma tumor progression. In this study, we sought to down-regulate MMP-9 expression by stably transfecting a high-grade glioblastoma cell line with a plasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e78f2952e308c71b2439f6b5791925c7
http://olympias.lib.uoi.gr/jspui/handle/123456789/18411

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Downregulation of the urokinase-type plasminogen activator receptor through inhibition of translation by antisense oligonucleotide suppresses invasion of human glioblastoma cells

Autor: Mohan, P. M., Lakka, S. S., Mohanam, S., Kin, Y., Sawaya, R., Kyritsis, A. P., Nicolson, G. L., Rao, J. S.

We previously showed that downregulation of the urokinase-type plasminogen activator receptor (uPAR) in the SNB19 human glioblastoma cell line by the stable transfection of a plasmid expressing a 300 bp antisense sequence to the 5' end of the uPAR ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::aab591c8fa1996d1c6a4ed00842068ba
http://olympias.lib.uoi.gr/jspui/handle/123456789/22339

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Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: modulation of migration and invasion of human malignant glioma cells

Autor: Chintala, S. K., Kyritsis, A. P., Mohan, P. M., Mohanam, S., Sawaya, R., Gokslan, Z., Yung, W. K., Steck, P., Uhm, J. H., Aggarwal, B. B., Rao, J. S.

Cell-matrix interactions exert a profound influence on cell function and behavior. Our earlier observations suggested that disruption of the actin cytoskeleton results in the inhibition of phorbol ester-induced matrix metalloproteinase (MMP)-9 expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::87e2f5e3080d9f15d7d2dda22870b270
http://olympias.lib.uoi.gr/jspui/handle/123456789/23958

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Elevated levels of urokinase-type plasminogen activator and its receptor during tumor growth in vivo

Autor: Mohanam, S., Go, Y., Sawaya, R., Venkaiah, B., Mohan, P. M., Kouraklis, G. P., Gokaslan, Z. L., Lagos, G. K., Rao, J. S.

Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) are important in the regulation of tumor tissue progenesis, cell differentiation, tumor cell motility, and tumor cell invasiveness. We have recently reported that the levels of uPA an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::0a31e43ba75f0cc5092d3ac4df5579ea
http://olympias.lib.uoi.gr/jspui/handle/123456789/22002

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Increased invasion of neuroglioma cells transfected with urokinase plasminogen activator receptor cDNA

Autor: Mohanam, S., Chintala, S. K., Mohan, P. M., Sawaya, R., Lagos, G. K., Gokaslan, Z. L., Kouraklis, G. P., Rao, J. S.

The cell-surface urokinase plasminogen activator receptor (uPAR) plays a key role in regulating plasminogen cleavage during extracellular proteolysis. Our recent results demonstrated that uPAR expression is critical for the invasiveness of human glio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::9edf49256132cd3ea4a5e7ca1ebc56d8
http://olympias.lib.uoi.gr/jspui/handle/123456789/20869

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Periodical

A novel interaction of PAK4 with PPARγ to regulate Nox1 and radiation-induced epithelial-to-mesenchymal transition in glioma

Autor: Kesanakurti, D, Maddirela, D, Banasavadi-Siddegowda, Y K, Lai, T-H, Qamri, Z, Jacob, N K, Sampath, D, Mohanam, S, Kaur, B, Puduvalli, V K

Publikováno v: Oncogene; September 2017, Vol. 36 Issue: 37 p5309-5320, 12p

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