Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mohanad H. Nada"'
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Human Vγ2Vδ2 (also termed Vγ9Vδ2) T cells play important roles in microbial and tumor immunity by monitoring foreign- and self-prenyl pyrophosphate metabolites in isoprenoid biosynthesis. Accumulation of isoprenoid metabolites after bisphosphonat
Externí odkaz:
https://doaj.org/article/44888b298b5348eaa2d0982d33df0a10
Publikováno v:
J Immunol
Vγ2Vδ2 T cells play important roles in human immunity to pathogens and tumors. Their TCRs respond to the sensing of isoprenoid metabolites, such as (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and isopentenyl pyrophosphate, by butyrophilin (BTN)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44b3effae7ee3774769a7a816151a0a
https://doi.org/10.4049/jimmunol.1801252
https://doi.org/10.4049/jimmunol.1801252
Autor:
Mohanad H. Nada, Asuka Kumagai, Craig T. Morita, Haruki Okamura, Yoshimasa Tanaka, Masashi Iwasaki, Kosuke Hayashi, Tomoharu Sugie, Nagahiro Minato, Masakazu Toi, Hirohito Kobayashi, Hong Wang, Hiroshi Kamitakahara, Kenji Matsumoto, Kaoru Murata-Hirai
Publikováno v:
Cancer Science
Cancer immunotherapy with human γδ T cells expressing Vγ2Vδ2 T cell receptor (also termed Vγ9Vδ2) has shown promise because of their ability to recognize and kill most types of tumors in a major histocombatibility complex (MHC) -unrestricted fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164b5de10cd57400f22732b5706222fb
http://europepmc.org/articles/PMC5834800
http://europepmc.org/articles/PMC5834800
Publikováno v:
Cancer Research. 78:3628-3628
Cancer immunotherapy is an effective treatment against a variety of malignancies. Checkpoint blockade with anti-PD-1 or anti-CTLA-4 antibodies has resulted in durable clinical responses. However, targeting PD-1 or PD-L1 provides clinical benefits for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dc701e854a32502c3a38ffdb5135d0c
https://doi.org/10.1158/1538-7445.am2018-3628
https://doi.org/10.1158/1538-7445.am2018-3628
Publikováno v:
Journal for Immunotherapy of Cancer
Background Human γδ T cells expressing Vγ2Vδ2 T cell receptors monitor foreign- and self-prenyl pyrophosphate metabolites in isoprenoid biosynthesis to mediate immunity to microbes and tumors. Adoptive immunotherapy with Vγ2Vδ2 T cells has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a576ade743663c0beb08dddf1d2349f
http://europepmc.org/articles/PMC5319075
http://europepmc.org/articles/PMC5319075
Publikováno v:
European Journal of Cancer. 110:S23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eca343c8089390b6aaec44be0712248f
https://doi.org/10.1016/j.ejca.2019.01.075
https://doi.org/10.1016/j.ejca.2019.01.075
Publikováno v:
The Journal of Immunology. 200:122.13-122.13
Human γδ T cells expressing Vγ2Vδ2 TCRs monitor foreign- and self-prenyl pyrophosphate metabolites in isoprenoid biosynthesis to mediate immunity to microbes and tumors. Bisphosphonate treatment of tumors results in increases in isopentenyl pyrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409b154e1895109bdfc7e304577bc7eb
https://doi.org/10.4049/jimmunol.200.supp.122.13
https://doi.org/10.4049/jimmunol.200.supp.122.13
Autor:
Tomohisa Kuzuyama, Kia-Joo Puan, Craig T. Morita, Bradley D. Jones, Mohanad H. Nada, Grefachew Workalemahu, Hong Wang, Chenggang Jin
Human Vγ2Vδ2 T cells monitor isoprenoid metabolism by recognizing foreign (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), a metabolite in the 2-C-methyl-d-erythritol-4-phosphate pathway used by most eubacteria and apicomplexan parasites, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0d3a0e226e45f356f81f0fc910d507
https://europepmc.org/articles/PMC4241231/
https://europepmc.org/articles/PMC4241231/
Autor:
Tanaka, Yoshimasa, Murata‐Hirai, Kaoru, Iwasaki, Masashi, Matsumoto, Kenji, Hayashi, Kosuke, Kumagai, Asuka, Nada, Mohanad H., Wang, Hong, Kobayashi, Hirohito, Kamitakahara, Hiroshi, Okamura, Haruki, Sugie, Tomoharu, Minato, Nagahiro, Toi, Masakazu, Morita, Craig T.
Publikováno v:
Cancer Science; Mar2018, Vol. 109 Issue 3, p587-599, 13p