Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Mohana Rao Vippila"'
Autor:
Deviprasad R. Gollapalli, Gregory D. Cuny, Adhar C. Manna, Natalia Maltseva, Barry B. Snider, Yubo Zhang, Mohana Rao Vippila, Ann P. Lawson, Lizbeth Hedstrom, Minjia Zhang, Youngchang Kim, David M Rothstein, Shibin Chacko, Petr Kuzmic, Xingyou Wang, Andrzej Joachimiak, Ryan T Cullinane, Gyan Modi, Gary M Marqus, Ambrose L. Cheung, Judy L.M. Kotler
Publikováno v:
ACS Infectious Diseases. 7:3062-3076
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5'-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a38314a14bd8ed48fa872a866f2505
https://doi.org/10.1021/acsinfecdis.1c00342
https://doi.org/10.1021/acsinfecdis.1c00342
Autor:
Gyan, Modi, Gary M, Marqus, Mohana Rao, Vippila, Deviprasad R, Gollapalli, Youngchang, Kim, Adhar C, Manna, Shibin, Chacko, Natalia, Maltseva, Xingyou, Wang, Ryan T, Cullinane, Yubo, Zhang, Judy L M, Kotler, Petr, Kuzmic, Minjia, Zhang, Ann P, Lawson, Andrzej, Joachimiak, Ambrose, Cheung, Barry B, Snider, David M, Rothstein, Gregory D, Cuny, Lizbeth, Hedstrom
Publikováno v:
ACS Infect Dis
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5’-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ad78a428808eb670c119d890ec480eb
https://pubmed.ncbi.nlm.nih.gov/34590817
https://pubmed.ncbi.nlm.nih.gov/34590817
Mycophenolic anilides as broad specificity inosine-5’-monophosphate dehydrogenase (IMPDH) inhibitors
Autor:
Xingyou Wang, Seungheon Lee, Angela F. Ku, Mohana Rao Vippila, Gregory D. Cuny, Yong Wang, Minjia Zhang, Lizbeth Hedstrom
Publikováno v:
Bioorg Med Chem Lett
Inosine-5′-monophosphate dehydrogenase (IMPDH) is a potential target for microorganisms. However, identifying inhibitor design determinants for IMPDH orthologs continues to evolve. Herein, a series of mycophenolic anilide inhibitors of Cryptosporid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058e1cae1f031c0d4c30178db60d94d1
https://doi.org/10.1016/j.bmcl.2020.127543
https://doi.org/10.1016/j.bmcl.2020.127543
Publikováno v:
Organic letters. 18(18)
A synthesis of gombamide A (1) using N-terminal peptide extension, oxidative disulfide bond formation, and late-stage 4-hydroxystyrylamide installation has been achieved. This divergent method was also utilized to synthesize several gombamide A deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea875af1c6c963f96700b0767154d5a3
https://pubmed.ncbi.nlm.nih.gov/27603447
https://pubmed.ncbi.nlm.nih.gov/27603447
Publikováno v:
Journal of natural products. 78(10)
Thiochondrilline C (4) was previously isolated from Verrucisispora sp. and reported to have moderate cytotoxicity against human lung adenocarcinoma cells. Herein, we report the synthesis of thiochondrilline C by N-terminal peptide extension, oxidativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f827d81da3902f71b7fe1d7b6b48335f
https://pubmed.ncbi.nlm.nih.gov/26444379
https://pubmed.ncbi.nlm.nih.gov/26444379