Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Mohan Manikkam"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Epigenetic mechanisms associated with the differentiation state of cancer cells and their heterogeneity influence tumor responses to oncogene-targeted therapies. In this study, the authors perform an epigenetic compound screen and single-cell analysi
Externí odkaz:
https://doaj.org/article/7fa8d14fcf1945ae8d04495e5d1b8978
Autor:
Natacha Comandante-Lou, Mehwish Khaliq, Divya Venkat, Mohan Manikkam, Mohammad Fallahi-Sichani
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007688 (2020)
Cell-to-cell variability generates subpopulations of drug-tolerant cells that diminish the efficacy of cancer drugs. Efficacious combination therapies are thus needed to block drug-tolerant cells via minimizing the impact of heterogeneity. Probabilis
Externí odkaz:
https://doaj.org/article/69b1a17685534dfc860ba61fbed15837
Autor:
Akash K. Kaushik, Ali Shojaie, Katrin Panzitt, Rajni Sonavane, Harene Venghatakrishnan, Mohan Manikkam, Alexander Zaslavsky, Vasanta Putluri, Vihas T. Vasu, Yiqing Zhang, Ayesha S. Khan, Stacy Lloyd, Adam T. Szafran, Subhamoy Dasgupta, David A. Bader, Fabio Stossi, Hangwen Li, Susmita Samanta, Xuhong Cao, Efrosini Tsouko, Shixia Huang, Daniel E. Frigo, Lawrence Chan, Dean P. Edwards, Benny A. Kaipparettu, Nicholas Mitsiades, Nancy L. Weigel, Michael Mancini, Sean E. McGuire, Rohit Mehra, Michael M. Ittmann, Arul M. Chinnaiyan, Nagireddy Putluri, Ganesh S. Palapattu, George Michailidis, Arun Sreekumar
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The molecular alterations driving anti-androgen resistance in prostate cancer are unclear. Here, the authors show, using a network-based approach, that inhibition of the hexosamine biosynthetic pathway is necessary to develop resistance and that incr
Externí odkaz:
https://doaj.org/article/928bd0a4d45444ac89e49f796339b9e4
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102091 (2014)
Environmental compounds including fungicides, plastics, pesticides, dioxin and hydrocarbons can promote the epigenetic transgenerational inheritance of adult-onset disease in future generation progeny following ancestral exposure during the critical
Externí odkaz:
https://doaj.org/article/d882edcb31b64dcfa24c7998d6d276e2
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55387 (2013)
Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1-F3) following ancestral exposure during fetal gonadal sex determination. The current study was designed to dete
Externí odkaz:
https://doaj.org/article/33bfe37f651640c39a1f388426b90244
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46249 (2012)
Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination. The current study examined the ability of dioxin (2,3,7
Externí odkaz:
https://doaj.org/article/37dd3ad3bc65410b84650cb512b68d9d
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31901 (2012)
Environmental factors during fetal development can induce a permanent epigenetic change in the germ line (sperm) that then transmits epigenetic transgenerational inheritance of adult-onset disease in the absence of any subsequent exposure. The epigen
Externí odkaz:
https://doaj.org/article/8532ad40efc14364a36d471dfb939bb3
Autor:
Eric Nilsson, Ginger Larsen, Mohan Manikkam, Carlos Guerrero-Bosagna, Marina I Savenkova, Michael K Skinner
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36129 (2012)
The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon m
Externí odkaz:
https://doaj.org/article/a28fd078559b409fa243feb39158873c
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Hyperactivation of the MAPK signaling pathway motivates the clinical use of MAPK inhibitors for BRAF-mutant melanomas. Heterogeneity in differentiation state due to epigenetic plasticity, however, results in cell-to-cell variability in the state of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5486afed6a4826f3adcf3172c29bba9d
https://doaj.org/article/7fa8d14fcf1945ae8d04495e5d1b8978
https://doaj.org/article/7fa8d14fcf1945ae8d04495e5d1b8978
Autor:
Mohan Manikkam, Rebeca San Martin, Weijie Zhang, Petra den Hollander, Chandrashekar R. Ambati, James M. Arnold, Sendurai A. Mani, Andrew G. Sikora, Arun Sreekumar, Christy Charles, Uttam Rasaily, Esmeralda Ramirez-Pena, Yinghong Pan, Sujash S. Chatterjee, Franklin Gu, Nagireddy Putluri, David R. Rowley, Chandandeep Nagi, Balasubramanyam Karanam, Robiya Joseph, Xiang Zhang
Publikováno v:
Oncogene. 39:3226-3228
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33ffb7e4f3ce1a44ff53ce880871d9de
https://doi.org/10.1038/s41388-020-1252-1
https://doi.org/10.1038/s41388-020-1252-1