Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mohan Krishna Mallakuntla"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7862 (2024)
Mycobacterium tuberculosis (Mtb), a successful human pathogen, resides in host sentinel cells and combats the stressful intracellular environment induced by reactive oxygen and nitrogen species during infection. Mtb employs several evasion mechanisms
Externí odkaz:
https://doaj.org/article/bd671a9774e7473599e5625b4b9ec698
Publikováno v:
Carbohydrate Polymer Technologies and Applications, Vol 2, Iss , Pp 100077- (2021)
In this study, biologically active chitooligosaccharides (COS) D3–7 (D-deacetylated unit) and A5 (A-acetylated unit) were assessed for their suitability to reduce the viability of human breast cancer cell lines, BT-474 and SUM-159. The treatment wi
Externí odkaz:
https://doaj.org/article/8a70022332a440ea943f62bd1ec855ec
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1415 (2022)
Tuberculosis (TB) remains a global health problem and the emergence of HIV has further worsened it. Long chemotherapy and the emergence of drug-resistance strains of Mycobacterium tuberculosis as well as HIV has aggravated the problem. This demands u
Externí odkaz:
https://doaj.org/article/f537ac9846004ba7b7bd04328e804406
Autor:
Namdev S. Togre, Ana M. Vargas, Gunapati Bhargavi, Mohan Krishna Mallakuntla, Sangeeta Tiwari
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10669 (2022)
The emergence of drug-resistant mycobacteria, including Mycobacterium tuberculosis (Mtb) and non-tuberculous mycobacteria (NTM), poses an increasing global threat that urgently demands the development of new potent anti-mycobacterial drugs. One of th
Externí odkaz:
https://doaj.org/article/a8de72f931db45aa931f78933256f129
Autor:
Mohan Krishna Mallakuntla, Papa Rao Vaikuntapu, Bhoopal Bhuvanachandra, Subha Narayan Das, Appa Rao Podile
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Humans have exploited natural resources for a variety of applications. Chitin and its derivative chitin oligosaccharides (CHOS) have potential biomedical and agricultural applications. Availability of CHOS with the desired length has been a
Externí odkaz:
https://doaj.org/article/d978bfdb29324565a6edf7e33c313060
Publikováno v:
International journal of biological macromolecules. 165
Transglycosylation (TG) by Enterobacter cloacae subsp. cloacae chitinase 2 (EcChi2) has been deciphered by site-directed mutagenesis. EcChi2 originally displayed feeble TG with chitin oligomer with a degree of polymerization (DP4), for a short durati
Autor:
Bhoopal Bhuvanachandra, Bellamkonda Ramakrishna, Appa Rao Podile, Papa Rao Vaikuntapu, Sheetal Uikey, D. Sivaramakrishna, Mohan Krishna Mallakuntla
Publikováno v:
International Journal of Biological Macromolecules. 115:1225-1232
The recombinant C-terminal domain of chitinase C of Chitinophaga pinensis (CpChiC-GH18C) exhibits the highest activity at pH 6.0 and 35 °C, with a Km of 76.13 (mg−1 ml), a kcat of 10.16 (s−1), and a kcat/Km of 0.133 (mg−1 ml s−1) on colloida
Publikováno v:
Carbohydrate Polymer Technologies and Applications, Vol 2, Iss, Pp 100077-(2021)
In this study, biologically active chitooligosaccharides (COS) D3–7 (D-deacetylated unit) and A5 (A-acetylated unit) were assessed for their suitability to reduce the viability of human breast cancer cell lines, BT-474 and SUM-159. The treatment wi
Autor:
Bhoopal Bhuvanachandra, Appa Rao Podile, Subha Narayan Das, Papa Rao Vaikuntapu, Mohan Krishna Mallakuntla
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Humans have exploited natural resources for a variety of applications. Chitin and its derivative chitin oligosaccharides (CHOS) have potential biomedical and agricultural applications. Availability of CHOS with the desired length has been a major lim
Publikováno v:
Enzyme and Microbial Technology. 143:109702
Bacterial chitinases recruited multiple accessory domains for the conversion of recalcitrant polysaccharides to simple soluble sugars/amino sugars. Here, we report detailed properties of a multi-domain GH18 chitinase from Enterobacter cloacae subsp.