Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mohan Basavaraju Kumar"'
An important aspect of molecular toxicology is the ability of a wide array of xenobiotics to alter gene transcription through soluble receptors. Over the past 20 years mechanistic studies have examined the ability of these receptors to be activated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2835727c6a52f2319759c41eafd47a
https://doi.org/10.1016/b978-0-12-801238-3.65234-0
https://doi.org/10.1016/b978-0-12-801238-3.65234-0
Autor:
Angela Edwards, Damodhar R. Kethidi, Colin M. Tice, Michael Lawless, Mitch Polley, Mohan Basavaraju Kumar, Robert Eugene Hormann, Subba Reddy Palli, Philippa R.N. Wolohan, Martha A. Dipietro, David W. Potter, Howard Smith
Publikováno v:
Journal of Biological Chemistry. 279:27211-27218
The insect steroid hormone 20-hydroxyecdysone works through a ligand-activated nuclear receptor, the ecdysone receptor (EcR), which plays critical roles in insect development and reproduction. The EcR has been exploited to develop insecticides to con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98124d7c2c93838451df758c21d3dbe0
https://doi.org/10.1074/jbc.m403839200
https://doi.org/10.1074/jbc.m403839200
Publikováno v:
Journal of Biological Chemistry. 274:22155-22164
The Ah receptor (AhR), a soluble cytosolic protein, mediates most of the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related environmental contaminants. The mechanism of ligand-mediated AhR activation has been, in part, elucidated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31a9def6b8e4c08bec0dfa407e1c347d
https://doi.org/10.1074/jbc.274.32.22155
https://doi.org/10.1074/jbc.274.32.22155
The ecdysone receptor (EcR), a member of the nuclear receptor superfamily, plays an important role in regulating development and reproduction in insects. The EcR binds to ecdysteroids and regulates transcription of genes that contain ecdysone respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707f8b767b3ca7fc7840af0e9fad2c67
https://europepmc.org/articles/PMC137484/
https://europepmc.org/articles/PMC137484/
Autor:
Mohan Basavaraju Kumar, John P. Vanden Heuvel, Preeti Ramadoss, Gary H. Perdew, Rashmeet K. Reen
Publikováno v:
The Journal of biological chemistry. 276(45)
The aryl hydrocarbon receptor (AhR), a basic helix-loop-helix/Per-Arnt-Sim transcription factor, mediates many of the toxic and biological effects of the environmental contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin, which include the transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220d0d267071a7dec1312cd89588100c
https://pubmed.ncbi.nlm.nih.gov/11551916
https://pubmed.ncbi.nlm.nih.gov/11551916
Publikováno v:
Molecular Therapy. 9:S119
The ecdysone receptor (EcR)-based gene switch is used to regulate gene expression in a ligand-dependent manner. Gene switches may have utility in human gene therapies that require a specifically regulated level of gene expression, where it is desirab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fa82868b5c3cc982ff38bf3a20a9b1b
https://doi.org/10.1016/j.ymthe.2004.06.255
https://doi.org/10.1016/j.ymthe.2004.06.255
Autor:
Dean Ervin Cress, Prasanna Kumar, Subba Reddy Palli, Henry Hoff, Anand K. Katakam, Mohan Basavaraju Kumar
Publikováno v:
Molecular Therapy. 9:S308
An ecdysone receptor (EcR)-based inducible gene regulation system that functions in mammalian cells in a tightly regulated fashion is described. This gene switch functions efficiently in a two-hybrid format in which heterologous DNA binding and trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e1c17468395bc08c69345029c2aca42
https://doi.org/10.1016/j.ymthe.2004.06.711
https://doi.org/10.1016/j.ymthe.2004.06.711