Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mohammed S. Ikram"'
Autor:
Alan Storey, M. Das, Ertan Saridogan, Lucy Ghali, M. Raveendran, B. Hacihanefioglu, O. Djahanbakhch, Mohammed S. Ikram
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:881-887
Context: Polycystic ovary syndrome (PCOS) represents the most common endocrine abnormality in women of reproductive age. The cause of PCOS remains largely unknown, but studies suggest an intrinsic ovarian abnormality. Objective: The objective of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718e844876ef3f3796c6f7cfb1b606c4
https://doi.org/10.1210/jc.2007-1650
https://doi.org/10.1210/jc.2007-1650
Autor:
Sandeep K. Nadendla, Fritz Aberger, Edel A. O'Toole, Graham W. Neill, Anna-Maria Frischauf, Michael P. Philpott, Tomos D.L. Williams, Lucy Ghali, Wesley J. Harrison, Judith L. Green, Mohammed S. Ikram, Lucia Bianchi
Publikováno v:
Carcinogenesis. 29:738-746
Basal cell carcinoma (BCC) of the skin is a highly compact, non-metastatic epithelial tumour type that may arise from the aberrant propagation of epidermal or progenitor stem cell (SC) populations. Increased expression of GLI1 is a common feature of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedb273a56a0bb9f0fc4d761b65458d0
https://doi.org/10.1093/carcin/bgn037
https://doi.org/10.1093/carcin/bgn037
Autor:
Edel A. O'Toole, S Basu, Hong Wan, Ming Yuan, Ian R. Hart, Mohammed S. Ikram, Felicity N. E. Gavins, Nuzhat Baksh, Kirsty Allen, Cathy Simpson
Publikováno v:
Stem Cells. 25:1286-1297
We showed previously that primary keratinocytes selected for low desmoglein 3 (Dsg3) expression levels exhibited increased colony-forming efficiency and heightened proliferative potential relative to cells with higher Dsg3 expression levels, characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cd3c45cd198a0fa420a398a7ef301f
https://doi.org/10.1634/stemcells.2006-0304
https://doi.org/10.1634/stemcells.2006-0304
Autor:
Irene M. Leigh, Edel A. O'Toole, Nimesh S. A. Patel, J. J. Vyas, Lucy Ghali, Judith L. Green, Mohammed S. Ikram, Alan Storey, Charlotte M. Proby
Publikováno v:
British Journal of Cancer
The molecular mechanisms that underlie the development of squamous cell skin cancers (SSC) are poorly understood. We have used oligonucleotide microarrays to compare the differences in cellular gene expression between a series of keratinocyte cell th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06591d13fe890673c0ab6f8c17d7dac5
http://europepmc.org/articles/PMC2361292
http://europepmc.org/articles/PMC2361292
Autor:
Gerhard Regl, Thomas Eichberger, Michael P. Philpott, Graham W. Neill, Fritz Aberger, Mohammed S. Ikram, Anthony G. Quinn, Anna-Maria Frischauf
Publikováno v:
Journal of Investigative Dermatology. 122:1503-1509
Sonic hedgehog (Shh) binds to its receptor patched (PTCH), leading to the activation and repression of target genes via the GLI family of zinc-finger transcription factors. Deregulation of the Shh pathway is associated with basal cell carcinoma (BCC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ca107bcfe9c796acc191ed5b091c21
https://doi.org/10.1111/j.0022-202x.2004.22612.x
https://doi.org/10.1111/j.0022-202x.2004.22612.x
Autor:
Harald Schnidar, Fritz Aberger, Mohammed S. Ikram, Thomas Eichberger, Gerhard Regl, Graham W. Neill, Maria Kasper, Michael P. Philpott, Anthony G. Quinn, Anna-Maria Frischauf
Publikováno v:
Oncogene. 23:1263-1274
In stratified epidermis, activation of the Hh/Gli signal transduction pathway has been implicated in the control of cell proliferation and tumorigenesis. The zinc-finger transcription factor Gli2 has been identified as critical mediator of the Hh sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fd3673af595a08a963977e3fa88353
https://doi.org/10.1038/sj.onc.1207240
https://doi.org/10.1038/sj.onc.1207240
Autor:
Graham W, Neill, Lucy R, Ghali, Judith L, Green, Mohammed S, Ikram, Michael P, Philpott, Anthony G, Quinn
Publikováno v:
Cancer research. 63(15)
Activation of the Sonic hedgehog signaling pathway, primarily through mutational inactivation of the PTCH1 gene, is associated with the development of basal cell carcinoma (BCC). Gli1, a member of the Gli family of transcription factors, is expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::61997cdadd3d3f3fb3631576ba90010d
https://pubmed.ncbi.nlm.nih.gov/12907651
https://pubmed.ncbi.nlm.nih.gov/12907651
Autor:
Emilios Gemenetzidis, Yong-Jie Lu, Eleni Pantazi, Mao X, Shan L, Gary Warnes, Michael P. Philpott, Muy-Teck Teh, Mohammed S. Ikram, Giuseppe Trigiante
Publikováno v:
Cell Death & Disease
Abnormal Sonic Hedgehog signalling leads to increased transcriptional activation of its downstream effector, glioma 2 (GLI2), which is implicated in the pathogenesis of a variety of human cancers. However, the mechanisms underlying the tumorigenic ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c91283e24aacd210410ed7252772e8c
https://doi.org/10.1038/cddis.2013.535
https://doi.org/10.1038/cddis.2013.535
Autor:
O. Djahanbakhch, M. Das, M. Raveendran, Ertan Saridogan, Alan Storey, B. Hacihanefioglu, Lucy Ghali, Mohammed S. Ikram
Publikováno v:
Obstetrical & Gynecological Survey. 63:579-580
The cause of polycystic ovary syndrome (PCOS), the commonest endocrine abnormality affecting women of reproductive age, remains in large part unknown, although studies to date suggest an intrinsic ovarian abnormality. Developing oocytes have an inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f0d5150328e97a38fd11dde4d390ae9
https://doi.org/10.1097/01.ogx.0000325911.61390.0c
https://doi.org/10.1097/01.ogx.0000325911.61390.0c
FOXE1, A New Transcriptional Target of GLI2 Is Expressed in Human Epidermis and Basal Cell Carcinoma
Autor:
Gerhard Regl, Graham W. Neill, Fritz Aberger, Michael P. Philpott, Thomas Eichberger, Anna-Maria Frischauf, Mohammed S. Ikram
Publikováno v:
Journal of Investigative Dermatology. (5):1180-1187
Sonic hedgehog (Hh) signaling plays a key role in epidermal development and skin cancer. Mutational inactivation of the tumor suppressor gene patched (PTCH) leads to constitutive activation of the Hh signaling pathway, resulting in activation of targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3ef3ef05ecbedeb062ad84457de48a