CAD increases the long noncoding RNA PUNISHER in small extracellular vesicles and regulates endothelial cell function via vesicular shuttling

Autor: Mohammed Rabiul Hosen, Qian Li, Yangyang Liu, Andreas Zietzer, Katharina Maus, Philip Goody, Shizuka Uchida, Eicke Latz, Nikos Werner, Georg Nickenig, Felix Jansen

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 388-405 (2021)

Long noncoding RNAs (lncRNAs) have emerged as biomarkers and regulators of cardiovascular disease. However, the expression pattern of circulating extracellular vesicle (EV)-incorporated lncRNAs in patients with coronary artery disease (CAD) is still

Externí odkaz: https://doaj.org/article/2aa90bca5c4f4e02a65c6c290034c080

NcRNAs in Vascular and Valvular Intercellular Communication

Autor: Benedikt Bartsch, Philip Roger Goody, Mohammed Rabiul Hosen, Denise Nehl, Neda Mohammadi, Andreas Zietzer, Philip Düsing, Alexander Pfeifer, Georg Nickenig, Felix Jansen

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

Non-coding RNAs have been shown to be important biomarkers and mediators of many different disease entities, including cardiovascular (CV) diseases like atherosclerosis, aneurysms, and valvulopathies. Growing evidence suggests a central role of ncRNA

Externí odkaz: https://doaj.org/article/3970af180b7a428b9fa75c53d17daea9

The RNA-binding protein hnRNPU regulates the sorting of microRNA-30c-5p into large extracellular vesicles

Autor: Andreas Zietzer, Mohammed Rabiul Hosen, Han Wang, Philip Roger Goody, Marc Sylvester, Eicke Latz, Georg Nickenig, Nikos Werner, Felix Jansen

Publikováno v: Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)

The transfer of microRNAs (miRs) via extracellular vesicles (EVs) is a functionally relevant mechanism of intercellular communication that regulates both organ homoeostasis and disease development. Little is known about the packaging of miRs into EVs

Externí odkaz: https://doaj.org/article/dc189fbce16f4f3db0186e354669dda6

Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles

Autor: Mohammed Rabiul Hosen, Philip Roger Goody, Andreas Zietzer, Xu Xiang, Sven Thomas Niepmann, Alexander Sedaghat, Vedat Tiyerili, Ramesh Chennupati, Joseph B. Moore, Reinier A. Boon, Shizuka Uchida, Jan-Malte Sinning, Sebastian Zimmer, Eicke Latz, Nikos Werner, Georg Nickenig, Felix Jansen

Publikováno v: Hosen, M R, Goody, P R, Zietzer, A, Xiang, X, Niepmann, S T, Sedaghat, A, Tiyerili, V, Chennupati, R, Moore, J B, Boon, R A, Uchida, S, Sinning, J-M, Zimmer, S, Latz, E, Werner, N, Nickenig, G & Jansen, F 2022, ' Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles ', Circulation, vol. 146, no. 24, pp. 1836-1854 . https://doi.org/10.1161/CIRCULATIONAHA.122.060258
Hosen, M R, Goody, P R, Zietzer, A, Xiang, X, Niepmann, S T, Sedaghat, A, Tiyerili, V, Chennupati, R, Moore, J B, Boon, R A, Uchida, S, Sinning, J-M, Zimmer, S, Latz, E, Werner, N, Nickenig, G & Jansen, F 2022, ' Circulating MicroRNA-122-5p Is Associated with a Lack of Improvement in Left Ventricular Function after Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles ', Circulation, vol. 146, no. 24, pp. 1836-1854 . https://doi.org/10.1161/CIRCULATIONAHA.122.060258
Circulation, 146(24), 1836-1854. Lippincott Williams and Wilkins

Background: Transcatheter aortic valve replacement (TAVR) is a well-established treatment option for high- and intermediate-risk patients with severe symptomatic aortic valve stenosis. A majority of patients exhibit improvements in left ventricular e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffa11ed46bcb97402d9900d0d17b189
https://pubmed.ncbi.nlm.nih.gov/35862223

Aortic Valve Stenosis

Autor: Sebastian Zimmer, Andreas Zietzer, Matti Adam, Dominik Christmann, Sven Thomas Niepmann, Mohammed Rabiul Hosen, Philip Roger Goody, Florian Bönner, Georg Nickenig, Felix Jansen

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 40:885-900

Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although interventional treatment options have rapidly improved in recent years, symptomatic aortic valve stenosis is still associated with high morbidity and mortality. Calci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e572477879dff81d06d4daf65ff17bf
https://doi.org/10.1161/atvbaha.119.313067