Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Mohammed R. Shaker"'
Autor:
Bahaa Al-mhanawi, Marta Boira Marti, Sean D. Morrison, Pallavi Gupta, Maath Alani, Peter G. Noakes, Ernst J. Wolvetang, Mohammed R. Shaker
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102725- (2023)
Summary: In response to the scarcity of advanced in vitro models dedicated to human CNS white matter research, we present a protocol to generate neuroectoderm-derived embedding-free human brain organoids enriched with oligodendrocytes. We describe st
Externí odkaz:
https://doaj.org/article/0dbd36b24b054391aee45e705a19e472
Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer’s disease
Autor:
Renuka Prasad, Hwajin Jung, Anderson Tan, Yonghee Song, Sungho Moon, Mohammed R. Shaker, Woong Sun, Junghee Lee, Hoon Ryu, Hyun Kook Lim, Eek-hoon Jho
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia and behavioral changes. Extracellular deposition of amyloid plaques (Aβ) and intracellular deposition of neurofibrillary tangles in neurons are the
Externí odkaz:
https://doaj.org/article/2059ccfe55644e8bae90c637012f62df
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Aging is a major risk factor for many neurodegenerative diseases. Klotho (KL) is a glycosylated transmembrane protein that is expressed in the choroid plexus and neurons of the brain. KL exerts potent anti-aging effects on multiple cell type
Externí odkaz:
https://doaj.org/article/74fa64d5680d4bdba32351255a2b38ac
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102673- (2022)
In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular m
Externí odkaz:
https://doaj.org/article/5eb1e60cd96a4b859c7212760b271302
Neural Epidermal Growth Factor-Like Like Protein 2 Is Expressed in Human Oligodendroglial Cell Types
Autor:
Mohammed R. Shaker, Amna Kahtan, Renuka Prasad, Ju-Hyun Lee, Giovanni Pietrogrande, Hannah C. Leeson, Woong Sun, Ernst J. Wolvetang, Andrii Slonchak
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Neural epidermal growth factor-like like 2 (NELL2) is a cytoplasmic and secreted glycosylated protein with six epidermal growth factor-like domains. In animal models, NELL2 is predominantly expressed in neural tissues where it regulates neuronal diff
Externí odkaz:
https://doaj.org/article/2f31c162c71843ce94c1b7c5ec1dd95f
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102564- (2021)
Epilepsy is a common neurological disorder characterized by seizures. Unfortunately, 30–40% of all epilepsy patients are resistant to at least two or more anti-seizure medications. Attempts to treat these patients and prevent further seizures neces
Externí odkaz:
https://doaj.org/article/dbdb1390adfe4023952bd328ec1e64d3
Autor:
Mohammed R. Shaker, Giovanni Pietrogrande, Sally Martin, Ju-Hyun Lee, Woong Sun, Ernst J. Wolvetang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Human stem cell derived brain organoids are increasingly gaining attention as an ideal model system for investigating neurological diseases, particularly those that involve myelination defects. However, current protocols for generating brain organoid
Externí odkaz:
https://doaj.org/article/f2310921ad594e789e3e1009cf8d45c1
Publikováno v:
Stem Cell Research, Vol 43, Iss , Pp - (2020)
Neural stem cells (NSCs) in the embryonic neocortex have the potential to generate a well-organized laminar architecture of the cerebral cortex through precise regulation of the proliferation, differentiation, and migration of neural cells. NSCs can
Externí odkaz:
https://doaj.org/article/3ab8eccc0c8d4f6d8327f6cd9c0dc7d3
Autor:
Nambin Yim, Seung-Wook Ryu, Kyungsun Choi, Kwang Ryeol Lee, Seunghee Lee, Hojun Choi, Jeongjin Kim, Mohammed R. Shaker, Woong Sun, Ji-Ho Park, Daesoo Kim, Won Do Heo, Chulhee Choi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Exosomes have been identified as promising vehicles for the in vivodelivery of therapeutic molecules. Here the authors design a system to load protein cargos into exosomes during their biogenesis using optogenetic control of protein-protein interacti
Externí odkaz:
https://doaj.org/article/5ecca384bd0343d7bad8c5a0f51a75de
Autor:
Ju-Hyun Lee, Hyogeun Shin, Mohammed R. Shaker, Hyun Jung Kim, Si-Hyung Park, June Hoan Kim, Namwon Lee, Minjin Kang, Subin Cho, Tae Hwan Kwak, Jong Woon Kim, Mi-Ryoung Song, Seung-Hae Kwon, Dong Wook Han, Sanghyuk Lee, Se-Young Choi, Im Joo Rhyu, Hyun Kim, Dongho Geum, Il-Joo Cho, Woong Sun
Publikováno v:
Nature Biomedical Engineering. 6:435-448
Human spinal-cord-like tissues induced from human pluripotent stem cells are typically insufficiently mature and do not mimic the morphological features of neurulation. Here, we report a three-dimensional culture system and protocol for the productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941df61948fe52cc270f467c18fb96d2
https://doi.org/10.1038/s41551-022-00868-4
https://doi.org/10.1038/s41551-022-00868-4