Zobrazeno 1 - 3 of 3 pro vyhledávání: '"Mohammed Naveed Shaik"'
1
Phase I study of glasdegib (PF‐04449913), an oral smoothened inhibitor, in Japanese patients with select hematologic malignancies
Autor: Geoffrey Chan, Mohammed Naveed Shaik, Tomoki Naoe, Yosuke Fujii, Wataru Munakata, Toshihiro Miyamoto, Adrian Woolfson, Goichi Yoshimoto, Yosuke Minami, Yukio Kobayashi, Xianxian Zheng, Chiho Ono, Mari Ikuta, Hironobu Minami, Masahiro Kobayashi, Yasushi Onishi
Publikováno v: Cancer Science
Summary The hedgehog signaling pathway regulates multiple morphogenetic processes during embryogenesis. Aberrant activation of the hedgehog pathway signal transduction in adult tissues is associated with the pathogenesis of hematologic malignancies a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351c6c85fb18f070e3d32565540716ad
http://europepmc.org/articles/PMC5543507
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2
Phase I/II trial of glasdegib in patients with primary or secondary myelofibrosis
Autor: Yun Su, Geoffrey Chan, Mohammed Naveed Shaik, Xiaoxi Zhang, Christine DiRienzo, Catriona Jamieson, Tetsuzo Tauchi, Moshe Talpaz, Mark L. Heaney, Norio Komatsu, Michael W. Deininger, Adrian Woolfson, Mirjana Zeremski, Ellen K. Ritchie, Ruben A. Mesa, Aaron T. Gerds, Hironobu Minami
Publikováno v: Journal of Clinical Oncology. 35:7061-7061
7061 Background: Glasdegib is a small molecule inhibitor of the Sonic Hedgehog pathway, and data from the single arm, lead-in cohort of a phase 1b/2 trial in myelofibrosis (MF) are shown. Methods: Patients (age ≥18 yrs) with primary/secondary MF pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c359999c42634f1b175ed07322d25786
https://doi.org/10.1200/jco.2017.35.15_suppl.7061
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