Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Mohammed Najeeb Al Hallak"'
Autor:
Husain Yar Khan, PhD, Mandana Kamgar, MD, Amro Aboukameel, MS, Sahar Bannoura, MS, Brian Y. Chung, PhD, Yiwei Li, MD, Mohammed Najeeb Al Hallak, MD, Philip A. Philip, MD, PhD, Susan Tsai, MD, Sanjeev Luther, MBA, William A. Hall, MD, Asfar S. Azmi, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 8, Iss 1, Pp 101122- (2023)
Purpose: Local tumor progression is a cause of significant morbidity and mortality in patients with pancreatic ductal adenocarcinoma (PDAC) with surgically unresectable disease. Novel and effective approaches to accomplish durable local control are u
Externí odkaz:
https://doaj.org/article/ee77f111869b4d7c8620b432196590f6
Autor:
Christopher El Mouhayyar, Omar Chehab, Emilia Khalil, Mohammed Najeeb Al Hallak, Amjad Kanj, Carter Bishop
Publikováno v:
Clinical Case Reports, Vol 8, Iss 1, Pp 9-12 (2020)
Abstract Paraneoplastic syndromes in lung malignancies can lead to leukemoid reaction with an elevation of eosinophils, neutrophils, and monocytes. The elevation of these three lineages together due to paraneoplastic syndromes has not been described
Externí odkaz:
https://doaj.org/article/6ae3cc9421bb4257934fd265c33890e0
Autor:
Rachel E. Sexton BS, Mohammed Najeeb Al Hallak MD, Md. Hafiz Uddin PhD, Maria Diab MD, Asfar S. Azmi PhD
Publikováno v:
Technology in Cancer Research & Treatment, Vol 19 (2020)
Gastric adenocarcinoma is a highly aggressive disease with poor overall survival. The aggressive nature of this disease is in part due to the high intra and inter tumoral heterogeneity and also due to the late diagnosis at presentation. Once progress
Externí odkaz:
https://doaj.org/article/7084db465f554c94b98de5dd13709236
Non-Coding RNAs in Pancreatic Cancer Diagnostics and Therapy: Focus on lncRNAs, circRNAs, and piRNAs
Publikováno v:
Cancers, Vol 13, Iss 16, p 4161 (2021)
Pancreatic cancer is an aggressive malignance with high mortality. The lack of early diagnosis and effective therapy contributes to the high mortality of this deadly disease. For a long time being, the alterations in coding RNAs have been considered
Externí odkaz:
https://doaj.org/article/298b40b7693643a59e2fbec332f29a97
Publikováno v:
Case Reports in Oncology, Vol 2, Iss 2, Pp 157-161 (2009)
153Sm-EDTMP is a radiopharmaceutical composed of EDTMP (ethylenediamine-tetramethylenephosphonate) and Samarium-153 [1]. 153Sm-EDTMP has an affinity for skeletal tissue and concentrates in areas with increased bone turnover; thus, it is successfully
Externí odkaz:
https://doaj.org/article/04112562c6c24a6a90c9840f9983367d
Autor:
Asfar S. Azmi, Anthony F. Shields, Ramzi M. Mohammad, Philip A. Philip, Dipesh Uprety, Hirva Mamdani, Yosef Landesman, Rafic Beydoun, Steve Kim, Mohammed Najeeb Al-Hallak, Yousef Mzannar, Sahar Bannoura, Rachel Sexton, Md. Hafiz Uddin, Amro Aboukameel, Yiwei Li, Misako Nagasaka, Husain Yar Khan
The identification of molecules that can bind covalently to KRAS G12C and lock it in an inactive GDP-bound conformation has opened the door to targeting KRAS G12C selectively. These agents have shown promise in preclinical tumor models and clinical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718acd53ed3f4593886fb1335899dd3c
https://doi.org/10.1158/2767-9764.c.6550541
https://doi.org/10.1158/2767-9764.c.6550541
Autor:
Asfar S. Azmi, Anthony F. Shields, Ramzi M. Mohammad, Philip A. Philip, Dipesh Uprety, Hirva Mamdani, Yosef Landesman, Rafic Beydoun, Steve Kim, Mohammed Najeeb Al-Hallak, Yousef Mzannar, Sahar Bannoura, Rachel Sexton, Md. Hafiz Uddin, Amro Aboukameel, Yiwei Li, Misako Nagasaka, Husain Yar Khan
Supplementary Figure 1. XPO1-KRAS synthetic lethal interaction identified using the Slorth database. Supplementary Figure 2. KRAS WT, KRAS G12D and KRAS G12V MEF cell lines were refractory to growth inhibition by selinexor or MRTX1257 or their combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8baa9b3cbc288ae8a6d95ae6fcdd3d
https://doi.org/10.1158/2767-9764.22544132.v1
https://doi.org/10.1158/2767-9764.22544132.v1
Autor:
Husain Yar Khan, Misako Nagasaka, Amro Aboukameel, Osama Alkhalili, Md. Hafiz Uddin, Sahar Bannoura, Yousef Mzannar, Ibrahim Azar, Eliza Beal, Miguel Tobon, Steve Kim, Rafic Beydoun, Erkan Baloglu, William Senapedis, Bassel El-Rayes, Philip A. Philip, Ramzi M. Mohammad, Anthony F. Shields, Mohammed Najeeb Al-Hallak, Asfar S. Azmi
Publikováno v:
bioRxiv
KRASG12C inhibitors have revolutionized the treatment landscape for cancer patients harboring the G12C mutant isoform of KRAS. With the recent FDA approval of sotorasib and adagrasib, patients now have access to more promising treatment options. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf004144758091e6e3046d4c1478a526
https://doi.org/10.1101/2023.03.27.534309
https://doi.org/10.1101/2023.03.27.534309
Autor:
Misako Nagasaka, Joanne Xiu, W. Michael Korn, Asfar S. Azmi, Yasmine Baca, Gerold Bepler, Hafiz Uddin, Mohammad Fahad Bin Asad, Michael J. Demeure, Ammar Sukari, Stephen V. Liu, Jorge Nieva, Luis E. Raez, Gilberto Lopes, Mohammed Najeeb Al Hallak, Bing Xia, Patrick C. Ma, Dipesh Uprety, Hirva Mamdani, Chul Kim, Sonam Puri, Hossein Borghaei, Dan Magee
Publikováno v:
Lung Cancer
Background Nuclear protein transport is essential in guiding the traffic of important proteins and RNAs between the nucleus and cytoplasm. Export of proteins from the nucleus is mostly regulated by Exportin 1 (XPO1). In cancer, XPO1 is almost univers
Autor:
Misako Nagasaka, Mohammed Najeeb Al Hallak, Samer Alkassis, Jami Fukui, Fares Alsawah, Ibrahim Azar, Kalub Fedak, Ammar Sukari
Publikováno v:
Lung Cancer: Targets and Therapy. 12:103-114
Human epidermal growth factor receptor 2 (HER2) is a proto-oncogene that, when mutated or overexpressed, plays an important role in oncogenesis. The landscape of HER2-positive breast cancer has changed dramatically over the past 2 decades with the FD