Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Mohammed N. Tantawy"'
Autor:
Mohammed N. Tantawy, J. Oliver McIntyre, Fiona Yull, M. Wade Calcutt, Dmitry S. Koktysh, Andrew J. Wilson, Zhongliang Zu, Jeff Nyman, Julie Rhoades, Todd E. Peterson, Daniel Colvin, Lisa J. McCawley, Jerri. M. Rook, Barbara Fingleton, Marta Ann Crispens, Ronald D. Alvarez, John C. Gore
Publikováno v:
Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract Background It has been shown that tumor microenvironment (TME) hydroxyapatite (HAP) is typically associated with many malignancies and plays a role in tumor progression and growth. Additionally, acidosis in the TME has been reported to play
Externí odkaz:
https://doaj.org/article/9b560d0bef2f4ba0a581210d8528af70
Autor:
William J. Behof, Clayton A. Whitmore, Justin R. Haynes, Adam J. Rosenberg, Mohammed N. Tantawy, Todd E. Peterson, Fiona E. Harrison, Robert B. Beelman, Wellington Pham
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Ergothioneine (ERGO) is a rare amino acid mostly found in fungi, including mushrooms, with recognized antioxidant activity to protect tissues from damage by reactive oxygen species (ROS) components. Prior to this publication, the biodistribu
Externí odkaz:
https://doaj.org/article/9f1da49055e5462fa3b225a7997b562e
Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX‑1 in Ovarian Cancer
Autor:
Md. Jashim Uddin, Andrew J. Wilson, Brenda C. Crews, Paola Malerba, Md. Imam Uddin, Philip J. Kingsley, Kebreab Ghebreselasie, Cristina K. Daniel, Michael L. Nickels, Mohammed N. Tantawy, Elma Jashim, H. Charles Manning, Dineo Khabele, Lawrence J. Marnett
Publikováno v:
ACS Omega, Vol 4, Iss 5, Pp 9251-9261 (2019)
Externí odkaz:
https://doaj.org/article/19f9d0d415c744b08c6b7c5b7573c1a3
Autor:
Clayton A. Whitmore, Justin R. Haynes, William J. Behof, Adam J. Rosenberg, Mohammed N. Tantawy, Brian C. Hachey, Brian E. Wadzinski, Benjamin W. Spiller, Todd E. Peterson, Krista C. Paffenroth, Fiona E. Harrison, Robert B. Beelman, Printha Wijesinghe, Joanne A. Matsubara, Wellington Pham
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 742 (2022)
Background: Ergothioneine (ERGO) is a unique antioxidant and a rare amino acid available in fungi and various bacteria but not in higher plants or animals. Substantial research data indicate that ERGO is a physiological antioxidant cytoprotectant. Di
Externí odkaz:
https://doaj.org/article/882ef7134def4279bbf43586617325cc
Autor:
Na Luo, Mellissa J. Nixon, Paula I. Gonzalez-Ericsson, Violeta Sanchez, Susan R. Opalenik, Huili Li, Cynthia A. Zahnow, Michael L. Nickels, Fei Liu, Mohammed N. Tantawy, Melinda E. Sanders, H. Charles Manning, Justin M. Balko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Immunotherapy often fails as a single option treatment in cancer. Here, the authors show that targeting of DNA methyltransferases, such as DNMT1, can potentiate anti-tumor immunity and response to checkpoint inhibition by increasing MHC gene expressi
Externí odkaz:
https://doaj.org/article/ffb91a393be74576a78dffc6f8e78041
Autor:
Clayton A. Whitmore, Mariam I. Boules, William J. Behof, Justin R. Haynes, Dmitry Koktysh, Adam J. Rosenberg, Mohammed N. Tantawy, Wellington Pham
Publikováno v:
Molecules, Vol 26, Iss 8, p 2182 (2021)
Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer’s disease. However, so far, all of the studies were performed in vitro using extr
Externí odkaz:
https://doaj.org/article/cfd2eccd08f44b15bb163737bf294d85
Autor:
Donald D. Nolting, Michael eNickels, Mohammed N. Tantawy, James Y. H. Yu, Jingping eXie, Todd E. Peterson, Brenda A. Crews, Larry eMarnett, John C. Gore, Wellington ePham
Publikováno v:
Frontiers in Oncology, Vol 2 (2013)
The overall objectives of this research are to (i) develop azulene-based PET probes and (ii) image COX2 as a potential biomarker of breast cancer. Several lines of research have demonstrated that COX2 is overexpressed in breast cancer and that its pr
Externí odkaz:
https://doaj.org/article/1b862f94c41e45ce9df5659863a82995
Autor:
Lawrence J. Marnett, Jeffery Reese, Mohammed N. Tantawy, Mohammad Sib Ansari, Philip J. Kingsley, Imran Huda, Kebreab Ghebreselasie, Brenda C. Crews, Md. Jashim Uddin
PDF file - 312K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6174fa48b1ffb095fa3736a3ce97feb8
https://doi.org/10.1158/1940-6207.22526616
https://doi.org/10.1158/1940-6207.22526616
Autor:
Lawrence J. Marnett, Jeffery Reese, Mohammed N. Tantawy, Mohammad Sib Ansari, Philip J. Kingsley, Imran Huda, Kebreab Ghebreselasie, Brenda C. Crews, Md. Jashim Uddin
COX-2 is a major contributor to the inflammatory response and cancer progression so it is an important target for prevention and therapy. COX-2 is absent or expressed at low levels in most epithelial cells but is found at high levels in inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a97d86ba8cb183a797bee471f5688eb
https://doi.org/10.1158/1940-6207.c.6545154.v1
https://doi.org/10.1158/1940-6207.c.6545154.v1
Autor:
Lawrence J. Marnett, Jeffery Reese, Mohammed N. Tantawy, Mohammad Sib Ansari, Philip J. Kingsley, Imran Huda, Kebreab Ghebreselasie, Brenda C. Crews, Md. Jashim Uddin
Perspective on This Article from Fluorinated COX-2 Inhibitors as Agents in PET Imaging of Inflammation and Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356ca915215fe57d8e161e2d16410ad4
https://doi.org/10.1158/1940-6207.22526619
https://doi.org/10.1158/1940-6207.22526619