Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Mohammed Kouadir"'
Autor:
Mohammed Kouadir, Lifeng Yang, Rongrong Tan, Fushan Shi, Yun Lu, Siming Zhang, Xiaomin Yin, Xiangmei Zhou, Deming Zhao
Publikováno v:
PLoS ONE, Vol 7, Iss 2 (2012)
Externí odkaz:
https://doaj.org/article/d8f90249bdbe46bcba701270ec2c902a
Autor:
Mohammed Kouadir, Lifeng Yang, Rongrong Tan, Fushan Shi, Yun Lu, Siming Zhang, Xiaomin Yin, Xiangmei Zhou, Deming Zhao
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30756 (2012)
Microglial activation is a characteristic feature of the pathogenesis of prion diseases. The molecular mechanisms that underlie prion-induced microglial activation are not very well understood. In the present study, we investigated the role of the cl
Externí odkaz:
https://doaj.org/article/2f43144afba446a09e1d93bd3afb1b9c
Publikováno v:
Cell Death and Disease, Vol 10, Iss 2, Pp 1-11 (2019)
Cell Death & Disease
Cell Death & Disease
The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome has been implicated in a wide range of diseases, i
Publikováno v:
Journal of Molecular Neuroscience. 59:48-55
The cellular prion protein (PrP(C)) is a highly conserved glycoprotein anchored by glycosylphosphatidylinositol (GPI) to the cell surface and is also the source of pathogenic agent of scrapie prion protein (PrP(Sc)). Numerous researches have suggeste
Publikováno v:
Life Sciences. 135:9-14
Protein-misfolding diseases, such as Alzheimer's disease, type 2 diabetes, Prion diseases, and Parkinson's disease, are characterized by inflammatory reactions. In all these diseases, IL-1β (Interlukine-1β) has been shown to be an important regulat
Autor:
Lihua Xu, Deming Zhao, Xiaomin Yin, KeZong Qi, JinGuo Wang, Mohammed Kouadir, Lifeng Yang, Jian Tu, Xiangmei Zhou
Publikováno v:
Journal of Molecular Neuroscience. 52:107-116
Transmissible spongiform encephalopathies (TSEs) and Alzheimer's disease (AD) belong to a growing family of neurodegenerative disorders that is characterized by the generation of toxic protein aggregates in affected brains (PrP(Sc) and Aβ in TSEs an
Autor:
Lifeng Yang, Xiaomin Yin, Yongyao Fu, Fushan Shi, Xiangmei Zhou, Yang Yang, Mohammed Kouadir, Deming Zhao, Jihong Wang
Publikováno v:
Acta Biochimica et Biophysica Sinica. 45:973-978
The inflammatory responses in Alzheimer's disease and prion diseases are dominated by microglia activation. Three different phenotypes of microglial activation, namely classical activation, alternative activation, and acquired deactivation, have been
Autor:
Binrui Xu, Lifeng Yang, Deming Zhao, Xiaomin Yin, Siming Zhang, Xiangmei Zhou, Mohammed Kouadir, Yun Lu, Jiaxin Chang, Rongrong Tan
Publikováno v:
Acta Biochimica et Biophysica Sinica. 45:763-772
Prion diseases are a group of transmissible fatal neurodegenerative disorders of humans and animals, including bovine spongiform encephalopathy, scrapie, and Creutzfeldt-Jakob disease. Microglia, the resident macrophages of the central nervous system
Autor:
Chunfa Liu, Lifeng Yang, Deming Zhao, Tianjian Ding, Min Wang, Xiangmei Zhou, Jin Liu, Mohammed Kouadir, Fushan Shi, Yang Yang, Xiaomin Yin
Publikováno v:
The Journal of Infectious Diseases. 208:1849-1858
Background. Mycobacterium bovis, the causative agent of bovine tuberculosis, infects host macrophages and triggers production of the proinflammatory cytokine interleukin 1β (IL-1β). The mechanism by which macrophages become activated and secrete IL
Autor:
Wenyu Wu, Yunsheng Wang, Jin Wang, Lifeng Yang, Sher Hayat Khan, Mohammed Kouadir, Huarong Zou, Dongfeng Li, Rongrong Tan, Huinuan Wang, Deming Zhao, Xiangmei Zhou, Xiaomin Yin
Publikováno v:
Journal of Molecular Neuroscience. 51:591-601
The 37/67-kDa laminin receptor precursor (LRP)/laminin receptor (LR) is a cell surface receptor for cellular prion proteins and misfolded pathological prions. Previous research has shown that blocking or decreasing LRP/LP levels by anti-LRP/LR antibo