Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Mohammed I. Hawa"'
Autor:
Dirk S. Paul, Andrew E. Teschendorff, Mary A.N. Dang, Robert Lowe, Mohammed I. Hawa, Simone Ecker, Huriya Beyan, Stephanie Cunningham, Alexandra R. Fouts, Anita Ramelius, Frances Burden, Samantha Farrow, Sophia Rowlston, Karola Rehnstrom, Mattia Frontini, Kate Downes, Stephan Busche, Warren A. Cheung, Bing Ge, Marie-Michelle Simon, David Bujold, Tony Kwan, Guillaume Bourque, Avik Datta, Ernesto Lowy, Laura Clarke, Paul Flicek, Emanuele Libertini, Simon Heath, Marta Gut, Ivo G Gut, Willem H. Ouwehand, Tomi Pastinen, Nicole Soranzo, Sabine E. Hofer, Beate Karges, Thomas Meissner, Bernhard O. Boehm, Corrado Cilio, Helena Elding Larsson, Åke Lernmark, Andrea K. Steck, Vardhman K. Rakyan, Stephan Beck, R. David Leslie
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The incidence of type 1 diabetes is increasing, potentially implicating non-genetic factors. Here the authors conduct an epigenome-wide association study in disease-discordant twins and find increased DNA methylation variability at genes associated w
Externí odkaz:
https://doaj.org/article/74847440186d44ba8513e31e9862b708
Autor:
Vardhman K Rakyan, Huriya Beyan, Thomas A Down, Mohammed I Hawa, Siarhei Maslau, Deeqo Aden, Antoine Daunay, Florence Busato, Charles A Mein, Burkhard Manfras, Kerith-Rae M Dias, Christopher G Bell, Jörg Tost, Bernhard O Boehm, Stephan Beck, R David Leslie
Publikováno v:
PLoS Genetics, Vol 7, Iss 9, p e1002300 (2011)
Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ∼50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease. Although significant progress has been made in eluc
Externí odkaz:
https://doaj.org/article/1ece33ca61264c7a8de0aef9e3032afd
Autor:
Paolo Pozzilli, Gaetano Leto, Nicola Napoli, Rocky Strollo, Valentina Greto, Giuseppe Defeudis, Silvia Manfrini, Mohammed I. Hawa, Chiara Moretti, Giuseppe Campagna, Raffaella Buzzetti, Nirad (Nirad ), R. David Leslie, Simona Zampetti, Andrea Palermo, Luca D'Onofrio, Action Lada Study Groups
Purpose Bone formation is impaired in both type 1 diabetes and type 2 diabetes (T2D), whereas sclerostin, an antagonist of bone formation, is increased in T2D only. No data are available on latent autoimmune diabetes in adults (LADA), an autoimmune t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5346da5752d471eb38beb1989261e594
https://doi.org/10.1210/jc.2017-02274
https://doi.org/10.1210/jc.2017-02274
Autor:
Mohammed I. Hawa, R. David Leslie, Vito Lampasona, Alistair J K Williams, Anette-G. Ziegler, Stephanie Krause, Samuel T. Jerram, Peter Achenbach, Ezio Bonifacio
Publikováno v:
Achenbach, P, Hawa, M I, Krause, S, Lampasona, V, Jerram, S T, Williams, A J K, Bonifacio, E, Ziegler, A G, Leslie, R D 2018, ' Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes : Action LADA 12 ', Diabetologia, vol. 61, no. 7, pp. 1644-1649 . https://doi.org/10.1007/s00125-018-4605-3
Diabetologia
Diabetologia 61, 1644-1649 (2018)
Diabetologia
Diabetologia 61, 1644-1649 (2018)
Aims/hypothesis Adult-onset type 1 diabetes, in which the 65 kDa isoform of GAD (GAD65) is a major autoantigen, has a broad clinical phenotype encompassing variable need for insulin therapy. This study aimed to evaluate whether autoantibodies against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b7903e905ee158585adad3646e41a0
https://research-information.bris.ac.uk/ws/files/163728264/Achenbach2018_Article_AutoantibodiesToN_terminallyTr.pdf
https://research-information.bris.ac.uk/ws/files/163728264/Achenbach2018_Article_AutoantibodiesToN_terminallyTr.pdf
Autor:
R. David G. Leslie, Andrea K. Steck, Harold Snieder, Pamela R. Fain, Mohammed I. Hawa, Stavroula A. Paschou, Fruehling V. Rijsdijk, Bin Wang, Bernhard O. Boehm
Publikováno v:
Diabetologia, 58(9), 2079-2086. SPRINGER
Aims/hypothesis The discordance status of (autoimmune) type 1 diabetes within monozygotic twin pairs points to the importance of environmental factors. The aim of this study was to investigate whether the environmental events causing type 1 diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f720bad277ed96d3bf5828fd4f039676
https://doi.org/10.1007/s00125-015-3664-y
https://doi.org/10.1007/s00125-015-3664-y
Autor:
Graham A. Hitman, Richard David Leslie, H. Andrew W. Neil, Thomas O. Ola, Chuan Chuan Wun, David A. DeMicco, Paul N. Durrington, D. John Betteridge, Mohammed I. Hawa, Weihang Bao, Ana Paula Buchan, Helen M. Colhoun, John H. Fuller
Publikováno v:
Diabetes Care. 37:1643-1649
OBJECTIVE Diabetes-associated autoantibodies can be detected in adult-onset diabetes, even when initially non–insulin requiring, i.e., with latent autoimmune diabetes. We aimed to identify adult-onset autoimmune diabetes in patients with establishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf3a782882c8b53a6d6c0a157c6a2fd
https://doi.org/10.2337/dc13-2383
https://doi.org/10.2337/dc13-2383
Autor:
Rhys Williams, Cinzia Sarti, Paolo Pozzilli, Mohammed I. Hawa, Alberto de Leiva, Raffaella Buzzetti, Charles Thivolet, Nanette C. Schloot, Steven J. Hunter, David R. Hadden, Sinead Brophy, Jaakko Tuomilehto, Huriya Beyan, Knud Bonnet Yderstræde, Didac Mauricio, Richard David Leslie, Guntram Schernthaner, Werner A. Scherbaum, Stavroula A Paschou, Henning Beck-Neilsen, Hubert Kolb
Publikováno v:
Diabetes Care. 36:908-913
OBJECTIVE Specific autoantibodies characterize type 1 diabetes in childhood but are also found in adult-onset diabetes, even when initially non–insulin requiring, e.g., with latent autoimmune diabetes (LADA). We aimed to characterize adult-onset au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52dcd44cc2ee0dedef423f73e422210b
https://doi.org/10.2337/dc12-0931
https://doi.org/10.2337/dc12-0931
Autor:
Steven J. Hunter, Paolo Pozzilli, M. N. Pham, Nanette C. Schloot, Matthias Schott, Richard David Leslie, Charles Thivolet, Jochen Seissler, Guntram Schernthaner, Hubert Kolb, Werner A. Scherbaum, Mohammed I. Hawa
Publikováno v:
Diabetes Care
Diabetes Care, American Diabetes Association, 2016, 39 (11), pp.1932-1939. ⟨10.2337/dc16-0293⟩
Diabetes Care, American Diabetes Association, 2016, 39 (11), pp.1932-1939. ⟨10.2337/dc16-0293⟩
OBJECTIVE We related organ-specific autoantibodies, including diabetes-associated autoantibodies (DAAs) and non-DAAs to systemic cytokines/chemokines in type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS From the European Action LADA (latent aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24614047f573d1efe30436336b6434cb
https://hal.archives-ouvertes.fr/hal-01850295
https://hal.archives-ouvertes.fr/hal-01850295
Autor:
Harriëtte Riese, John C. Hutton, Harold Snieder, Howard W. Davidson, G. Beretta, Huibert Burger, Bernhard O. Boehm, Michael Schlosser, Mohammed I. Hawa, Richard David Leslie, Huriya Beyan
Publikováno v:
Diabetes
In type 1 diabetes, diabetes-associated autoantibodies, including islet cell antibodies (ICAs), reflect adaptive immunity, while increased serum Nε-carboxymethyl-lysine (CML), an advanced glycation end product, is associated with proinflammation. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0447479d817aa5fc8398520da9f732
https://doi.org/10.2337/db11-0971
https://doi.org/10.2337/db11-0971
Autor:
Robert M. Cohen, Raymond Edwards, Harold Snieder, Christopher J. Lindsell, Mohammed I. Hawa, Stuart Blinko, Tim D. Spector, R. David G. Leslie, Huriya Beyan
Publikováno v:
Diabetes Care. 29:1739-1743
OBJECTIVE—HbA1c (A1C) is substantially determined by genetic factors not shared in common with glucose. Fractions of the variance in A1C, the glycation gap (GG; previously called the glycosylation gap) and the hemoglobin glycosylation index, correl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02506c01d1a91cfbc64c552251d302d7
https://doi.org/10.2337/dc06-0286
https://doi.org/10.2337/dc06-0286