Výsledky vyhledávání - "Mohammed F. Azim"

Overexpression ofZNF342by juxtaposition withMPOpromoter/enhancer in the novel translocation t(17;19)(q23;q13.32) in pediatric acute myeloid leukemia and analysis of ZNF342 expression in leukemia

Autor: Deborah L. Shardy, E. Shannon Neeley, Nianxiang Zhang, Rizwan Naeem, Yihua Qiu, Mohammed F. Azim, Kathryn S. Poland, ZoAnne E. Dreyer, Robert A. Krance, Sharon E. Plon, Steven M. Kornblau

Publikováno v: Genes, Chromosomes and Cancer. 48:480-489

We report a novel translocation t(17;19)(q22;q13.32) found in 100% of blast cells from a pediatric acute myeloid leukemia (AML) patient. Fluorescence in situ hybridization and vectorette polymerase chain reaction were used to precisely map the chromo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c08551bd1338cc710f9e8b8d85bd105
https://doi.org/10.1002/gcc.20654

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C/EBPβ suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL

Autor: Matthew R. Folsom, Rizwan C. Naeem, Mohammed F. Azim, Rolf Marschalek, William T. Choi, Dean A. Lee, Nikolai A. Timchenko, Claus Meyer, Eric Kowarz

Publikováno v: Cancer Genetics and Cytogenetics. 177:108-114

Translocations involving the mixed-lineage leukemia gene (MLL) confer a poor prognosis in acute leukemias. In t(1;11)(q21;q23), MLL is fused reciprocally with AF1q. Here we describe a t(1;11)(q21;q23) with a secondary event involving insertion of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c9a1fa5f66b70d6a65a5ad2247417f
https://doi.org/10.1016/j.cancergencyto.2007.07.002

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A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of theTRC8 gene and predisposition to clear cell renal cell carcinoma

Autor: Mohammed F. Azim, Matthew Folsom, Rizwan Naeem, Sharon E. Plon, Kathryn S. Poland, Richard A. Goldfarb, Christopher Korch, Robert M. Gemmill, Harry A. Drabkin

Publikováno v: Genes, Chromosomes and Cancer. 46:805-812

Studying the molecular basis of familial renal cell carcinoma (RCC) has allowed identification of novel RCC genes involved in the pathogenesis of both inherited and sporadic RCC. We describe a constitutional balanced t(3;8)(p14;q24.1) translocation f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9e0ea8ed90d058ef6a7a4a19df79f7
https://doi.org/10.1002/gcc.20466

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C/EBP Suppression by Interruption of CUGBP1 Resulting from a Complex Rearrangement of MLL

Autor: Rolf Marschalek, Claus Meyer, Nicolai A. Timchenko, William T. Choi, Eric Kowarz, Dean A. Lee, Matthew R. Folsom, Mohammed F. Azim, Rizwan Naeem

Publikováno v: Blood. 108:2080-2080

CCAAT/enhancer binding proteins (C/EBPs) are transcription factors that play a role in myeloid differentiation and may be dysregulated in myeloid leukemias as targets of BCR/ABL, ETO, and FLT3 mutations. CUG triplet repeat binding protein-1 (CUGBP1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0427ada77892c768237a6ab4506ea761
https://doi.org/10.1182/blood.v108.11.2080.2080

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Identification of the Novel Chromosomal Translocation t(17;19)(q23;q13) in a Pediatric Patient with Acute Myeloid Leukemia

Autor: Deborah L. Shardy, Rizwan C. Naeem, Mohammed F. Azim, Sharon E. Plon

Publikováno v: Blood. 106:4344-4344

Chromosomal rearrangements have been associated with many hematologic malignancies. Identification of the genes involved in several of these rearrangements has provided information about the development of malignancy and has led to therapeutic interv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec05e6a85d75ce45a22753ff4d8803a1
https://doi.org/10.1182/blood.v106.11.4344.4344

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