Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mohammed E. El-asrag"'
Autor:
Sally C. Fletcher, Charlotte Hall, Tristan J. Kennedy, Sander Pajusalu, Monica H. Wojcik, Uncaar Boora, Chan Li, Kaisa Teele Oja, Eline Hendrix, Christian A.E. Westrip, Regina Andrijes, Sonia K. Piasecka, Mansi Singh, Mohammed E. El-Asrag, Anetta Ptasinska, Vallo Tillmann, Martin R. Higgs, Deanna A. Carere, Andrew D. Beggs, John Pappas, Rachel Rabin, Stephen J. Smerdon, Grant S. Stewart, Katrin Õunap, Mathew L. Coleman
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Although protein hydroxylation is a relatively poorly characterized posttranslational modification, it has received significant recent attention following seminal work uncovering its role in oxygen sensing and hypoxia biology. Although the fundamenta
Externí odkaz:
https://doaj.org/article/a5976c6079974ce1ba5fd035f60800a3
Autor:
Aditi Kumar, Mohammed Nabil Quraishi, Hafid O. Al-Hassi, Mohammed E. El-Asrag, Jonathan P. Segal, Manushri Jain, Helen Steed, Jeffrey Butterworth, Adam Farmer, John Mclaughlin, Andrew Beggs, Matthew J. Brookes
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionBile acid diarrhoea (BAD) is a common disorder that results from an increased loss of primary bile acids and can result in a change in microbiome. The aims of this study were to characterise the microbiome in different cohorts of patients
Externí odkaz:
https://doaj.org/article/cd4761a409274587af0e9a8c3d696cb4
Autor:
Kasun Wanigasooriya, Joao D. Barros-Silva, Louise Tee, Mohammed E. El-asrag, Agata Stodolna, Oliver J. Pickles, Joanne Stockton, Claire Bryer, Rachel Hoare, Celina M. Whalley, Robert Tyler, Toritseju Sillo, Christopher Yau, Tariq Ismail, Andrew D. Beggs
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectivesPartial or total resistance to preoperative chemoradiotherapy occurs in more than half of locally advanced rectal cancer patients. Several novel or repurposed drugs have been trialled to improve cancer cell sensitivity to radiotherapy, with
Externí odkaz:
https://doaj.org/article/a68422d51da247698891b279834c4704
Autor:
Samar Yahya, Claire E.L. Smith, James A. Poulter, Martin McKibbin, Gavin Arno, Jamie Ellingford, Kati Kämpjärvi, Muhammad I. Khan, Frans P.M. Cremers, Alison J. Hardcastle, Bruce Castle, David H.W. Steel, Andrew R. Webster, Graeme C. Black, Mohammed E. El-Asrag, Manir Ali, Carmel Toomes, Chris F. Inglehearn, Stuart Ingram, Rachel Taylor, Forbes Manson, Panagiotis Sergouniotis, Nikolas Pontikos, Michael Cheetham, Alessia Fiorentino, Susan Downes, Jing Yu, Stephanie Halford, Suzanne Broadgate, Veronica van Heyningen, John C. Ambrose, Prabhu Arumugam, Roel Bevers, Marta Bleda, Freya Boardman-Pretty, Christopher R. Boustred, Helen Brittain, Mark J. Caulfield, Georgia C. Chan, Greg Elgar, Tom Fowler, Adam Giess, Angela Hamblin, Shirley Henderson, Tim J.P. Hubbard, Rob Jackson, Louise J. Jones, Dalia Kasperaviciute, Melis Kayikci, Athanasios Kousathanas, Lea Lahnstein, Sarah E.A. Leigh, Ivonne U.S. Leong, Javier F. Lopez, Fiona Maleady-Crowe, Meriel McEntagart, Federico Minneci, Loukas Moutsianas, Michael Mueller, Nirupa Murugaesu, Anna C. Need, Peter O’Donovan, Chris A. Odhams, Christine Patch, Mariana Buongermino Pereira, Daniel Perez-Gil, John Pullinger, Tahrima Rahim, Augusto Rendon, Tim Rogers, Kevin Savage, Kushmita Sawant, Richard H. Scott, Afshan Siddiq, Alexander Sieghart, Samuel C. Smith, Alona Sosinsky, Alexander Stuckey, Mélanie Tanguy, Ana Lisa Taylor Tavares, Ellen R.A. Thomas, Simon R. Thompson, Arianna Tucci, Matthew J. Welland, Eleanor Williams, Katarzyna Witkowska, Suzanne M. Wood
Publikováno v:
Ophthalmology, 130, 68-76
Ophthalmology, 130, 1, pp. 68-76
Ophthalmology, 130, 1, pp. 68-76
To characterize the phenotype observed in a case series with macular disease and determine the cause.Multicenter case series.Six families (7 patients) with sporadic or multiplex macular disease with onset at 20 to 78 years, and 1 patient with age-rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507827933b913ead226b13ff8c186891
https://doi.org/10.1016/j.ophtha.2022.07.023
https://doi.org/10.1016/j.ophtha.2022.07.023
Autor:
Shafquat Zaman, Shahin Hajibandeh, Shahab Hajibandeh, Ali Yasen Y Mohamedahmed, Mohammed E El‐Asrag, Nabil Quraishi, Tariq H Iqbal, Andrew D Beggs
Publikováno v:
JGH Open. 6:711-722
To evaluate the demographic and prognostic significance of gastrointestinal (GI) symptoms in patients with coronavirus disease 2019 (COVID-19).A systematic search of electronic information sources was conducted. Combined overall effect sizes were cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116eb0ea10e578dafbddd4c285ae047c
https://doi.org/10.1002/jgh3.12812
https://doi.org/10.1002/jgh3.12812
A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia
Autor:
Nancy Kiwan, Peter W.R. Woodruff, Colin A. Johnson, Anneka Tomlinson, Steven J. Clapcote, Hassen Al-Amin, Iain D. Wilkinson, Sophia Ahmed, Joanna C. Neill, Jamshid Nazari, Ahmed H Al-Amri, Chris F. Inglehearn, Rifka S Chamali, Manir Ali, Tariq Mahmood, Mohammed E El-Asrag, Juliette Randerson Moor, Suhaila Ghuloum, Shabana Khan, Alastair G. Cardno, Hamid A. Alhaj, James A. Poulter
Publikováno v:
Schizophrenia Bulletin
We report a consanguineous family in which schizophrenia segregates in a manner consistent with recessive inheritance of a rare, partial-penetrance susceptibility allele. From 4 marriages between 2 sets of siblings who are half first cousins, 6 offsp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd63b2e3dc9d25cbc8977f0f37b9713
https://doi.org/10.1093/schbul/sbaa161
https://doi.org/10.1093/schbul/sbaa161
Autor:
Ahmed H. Al-Amri, Paul Armstrong, Mascia Amici, Clemence Ligneul, James Rouse, Mohammed E. El-Asrag, Andreea Pantiru, Valerie E. Vancollie, Hannah W.Y. Ng, Jennifer A. Ogbeta, Kirstie Goodchild, Jacob Ellegood, Christopher J. Lelliott, Jonathan G.L. Mullins, Amanda Bretman, Ruslan Al-Ali, Christian Beetz, Lihadh Al-Gazali, Aisha Al Shamsi, Jason P. Lerch, Jack R. Mellor, Abeer Al Sayegh, Manir Ali, Chris F. Inglehearn, Steven J. Clapcote
Publikováno v:
Al-Amri, A H, Armstrong, P, Amici, M, Ligneul, C, Mellor, J R & Clapcote, S J 2022, ' PDZD8 Disruption Causes Cognitive Impairment in Humans, Mice and Fruit Flies ', Biological Psychiatry, vol. 92, no. 4, pp. 323-334 . https://doi.org/10.1016/j.biopsych.2021.12.017
BackgroundThe discovery of coding variants in genes that confer risk of intellectual disability (ID) is an important step toward understanding the pathophysiology of this common developmental disability.MethodsHomozygosity mapping, whole-exome sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c438ba4555785a1f1213cff239036c
https://cronfa.swan.ac.uk/Record/cronfa59175/Download/59175__23886__9c4736e50fd24c30adbf62bd8435ff6d.pdf
https://cronfa.swan.ac.uk/Record/cronfa59175/Download/59175__23886__9c4736e50fd24c30adbf62bd8435ff6d.pdf
Autor:
Celina Whalley, Andrew D Beggs, Oliver J Pickles, Rachel Hoare, Kasun Wanigasooriya, Tortieju Sillo, Mohammed E. El-Asrag, Robert Tyler, Louise Tee, Tariq Ismail, João D. Barros-Silva, Agata Stodolna, Joanne D. Stockton, Christopher Yau, Claire Bryer
Partial or total resistance to preoperative chemoradiotherapy occurs in more than half of locally advanced rectal cancer patients. Several novel or repurposed drugs have been trialled to improve cancer cell sensitivity to radiotherapy, with limited s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f360ef6663cfb090a839265b85f193
https://doi.org/10.1101/2021.08.31.458326
https://doi.org/10.1101/2021.08.31.458326
Autor:
Carmel Toomes, Colin A. Johnson, Mohammed E El-Asrag, Gabrielle Wheway, Dina I. Abdelmottaleb, Subaashini Natarajan, Chris F. Inglehearn, Zakia Abdelhamed
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Abdelhamed, Z A, Abdelmottaleb, D I, El-Asrag, M E, Natarajan, S, Wheway, G, Inglehearn, C F, Toomes, C & Johnson, C A 2019, ' The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5 ', Scientific Reports . https://doi.org/10.1038/s41598-019-41940-5
Scientific Reports
Abdelhamed, Z A, Abdelmottaleb, D I, El-Asrag, M E, Natarajan, S, Wheway, G, Inglehearn, C F, Toomes, C & Johnson, C A 2019, ' The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5 ', Scientific Reports . https://doi.org/10.1038/s41598-019-41940-5
Scientific Reports
Primary cilia defects result in a group of related pleiotropic malformation syndromes known as ciliopathies, often characterised by cerebellar developmental and foliation defects. Here, we describe the cerebellar anatomical and signalling defects in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a878af3cb0befe19841937616d84e252
http://link.springer.com/article/10.1038/s41598-019-41940-5
http://link.springer.com/article/10.1038/s41598-019-41940-5
Autor:
Mohammed E, El-Asrag, Marta, Corton, Martin, McKibbin, Almudena, Avila-Fernandez, Moin D, Mohamed, Fiona, Blanco-Kelly, Carmel, Toomes, Chris F, Inglehearn, Carmen, Ayuso, Manir, Ali
Publikováno v:
Molecular vision. 28
To describe the clinical phenotype and genetic basis of non-syndromic retinitis pigmentosa (RP) in one family and two sporadic cases with biallelic mutations in the transcription factor neural retina leucine zipper (Exome sequencing was performed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b01e3dc6f2e67a7c1743c4d361eac076
https://pubmed.ncbi.nlm.nih.gov/35693422
https://pubmed.ncbi.nlm.nih.gov/35693422