Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Mohammed Dehbi"'
Autor:
Shadi Nejat, Kalhara R. Menikdiwela, Aliyah Efotte, Shane Scoggin, Bolormaa Vandanmagsar, Paul J. Thornalley, Mohammed Dehbi, Naima Moustaid-Moussa
Publikováno v:
Genes, Vol 14, Iss 10, p 1857 (2023)
Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity,
Externí odkaz:
https://doaj.org/article/9cb2e0fd0ae4409687705404fbf03f9f
Autor:
Abdoulaye Diane, Naela Mahmoud, Ilham Bensmail, Namat Khattab, Hanan A. Abunada, Mohammed Dehbi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Persistent ER stress, mitochondrial dysfunction and failure of the heat shock response (HSR) are fundamental hallmarks of insulin resistance (IR); one of the early core metabolic aberrations that leads to type 2 diabetes (T2D). The antioxida
Externí odkaz:
https://doaj.org/article/465554f1f2074a2bbf23553f639d9bf4
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease characterized by recognition of pancreatic β-cell proteins as self-antigens, called autoantigens (AAgs), followed by loss of pancreatic β-cells. (Pre-)proinsulin ([P]PI), glutamic acid d
Externí odkaz:
https://doaj.org/article/e5f1d9f275f74aa1944559f9db084e57
Autor:
Abdelkrim Khadir, Sina Kavalakatt, Preethi Cherian, Samia Warsame, Jehad Ahmed Abubaker, Mohammed Dehbi, Ali Tiss
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Heat shock protein 60 (HSP60) is a key protein in the crosstalk between cellular stress and inflammation. However, the status of HSP60 in diabetes and obesity is unclear. In the present study, we investigated the hypothesis that HSP60 expression leve
Externí odkaz:
https://doaj.org/article/5a26d558046e4a8382f9dbe6e6e57830
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Background. The impact of gender difference on the association between metabolic stress and cardiovascular disease (CVD) remains unclear. We have investigated, for the first time, the gender effect on the oxidative and inflammatory stress responses a
Externí odkaz:
https://doaj.org/article/4731eb694d964b569bef542007bc5a95
Autor:
Mohamed Abu-Farha, Mohammed Dehbi, Fiona Noronha, Ali Tiss, Monira Alarouj, Kazem Behbehani, Abdullah Bennakhi, Naser Elkum
Publikováno v:
International Journal of Endocrinology, Vol 2014 (2014)
Ghrelin is a stomach produced hormone that has been shown to have protective role against development of CVD which is a leading cause of death in the Arab world. The objective of this study is to examine the gender difference in association between t
Externí odkaz:
https://doaj.org/article/80c358eb4a994e7fa038da7f414f5faa
Autor:
Engin Baturcam, Jehad Abubaker, Ali Tiss, Mohamed Abu-Farha, Abdelkrim Khadir, Fahad Al-Ghimlas, Irina Al-Khairi, Preethi Cherian, Naser Elkum, Maha Hammad, Jeena John, Sina Kavalakatt, Cynthia Lehe, Samia Warsame, Kazem Behbehani, Said Dermime, Mohammed Dehbi
Publikováno v:
Mediators of Inflammation, Vol 2014 (2014)
RANTES and its CCR5 receptor trigger inflammation and its progression to insulin resistance in obese. In the present study, we investigated for the first time the effect of physical exercise on the expression of RANTES and CCR5 in obese humans. Fifty
Externí odkaz:
https://doaj.org/article/16f6576399ab47c9833eddc4c4dfadaf
Autor:
Jehad Abubaker, Ali Tiss, Mohamed Abu-Farha, Fahad Al-Ghimlas, Irina Al-Khairi, Engin Baturcam, Preethi Cherian, Naser Elkum, Maha Hammad, Jeena John, Sina Kavalakatt, Abdelkrim Khadir, Samia Warsame, Said Dermime, Kazem Behbehani, Mohammed Dehbi
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69217 (2013)
Obesity is a major risk factor for a myriad of disorders such as insulin resistance and diabetes. The mechanisms underlying these chronic conditions are complex but low grade inflammation and alteration of the endogenous stress defense system are wel
Externí odkaz:
https://doaj.org/article/666ddf3abdc1404c821ec7ed5e901542
Autor:
Mohamed Abu-Farha, Ali Tiss, Jehad Abubaker, Abdelkrim Khadir, Fahad Al-Ghimlas, Irina Al-Khairi, Engin Baturcam, Preethi Cherian, Naser Elkum, Maha Hammad, Jeena John, Sina Kavalakatt, Samia Warsame, Kazem Behbehani, Said Dermime, Mohammed Dehbi
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75342 (2013)
Sedentary lifestyle and excessive energy intake are prominent contributors to obesity; a major risk factors for the development of insulin resistance, type 2 diabetes and cardiovascular diseases. Elucidating the molecular mechanisms underlying these
Externí odkaz:
https://doaj.org/article/716f7c118b754556848f4700f7455040
Autor:
Mohammed Dehbi, Taher Uzzaman, Engin Baturcam, Abdelmoneim Eldali, Wilhelmina Ventura, Abderrezak Bouchama
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44100 (2012)
The molecular mechanisms that initiate the inflammatory response in heatstroke and their relation with tissue injury and lethality are not fully elucidated. We examined whether endogenous ligands released by damaged/stressed cells such as high-mobili
Externí odkaz:
https://doaj.org/article/c9335d73324e4aafb373965ed5d72e70