Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Mohammed Alsharifi"'
Autor:
Shannon C. David, Erin B. Brazel, Eve V. Singleton, Vikrant Minhas, Zoe Laan, Catherine Scougall, Austen Y. Chen, Hui Wang, Chloe J. Gates, Kimberley T. McLean, Jeremy S. Brown, Giuseppe Ercoli, Rachel A. Higgins, Paul V. Licciardi, Kim Mulholland, Justin B. Davies, Timothy R. Hirst, James C. Paton, Mohammed Alsharifi
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Streptococcus pneumoniae (Spn) remains a major cause of global mortality, with extensive antigenic diversity between capsular serotypes that poses an ongoing challenge for vaccine development. Widespread use of pneumococcal conjugate vaccine
Externí odkaz:
https://doaj.org/article/511cd819d0a5443389dd8f6cbe5374df
Autor:
Eve Victoria Singleton, Chloe Jayne Gates, Shannon Christa David, Timothy Raymond Hirst, Justin Bryan Davies, Mohammed Alsharifi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Influenza A virus presents a constant pandemic threat due to the mutagenic nature of the virus and the inadequacy of current vaccines to protect against emerging strains. We have developed a whole-inactivated influenza vaccine using γ-irradiation (
Externí odkaz:
https://doaj.org/article/7976515b8a6744d6af5fc1635d09c44f
Autor:
Timona S. Tyllis, Kevin A. Fenix, Todd S. Norton, Ervin E. Kara, Duncan R. McKenzie, Shannon C. David, Mohammed Alsharifi, Di Yu, Shaun R. McColl, Iain Comerford
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Crosstalk between T and B cells is crucial for generating high-affinity, class-switched antibody responses. The roles of CD4+ T cells in this process have been well-characterised. In contrast, regulation of antibody responses by CD8+ T cells is signi
Externí odkaz:
https://doaj.org/article/b40752eca7c74b949e6eafad9578fed3
Autor:
Andrew T. Crane, Matthew R. Chrostek, Venkatramana D. Krishna, Maple Shiao, Nikolas G. Toman, Clairice M. Pearce, Sarah K. Tran, Christopher J. Sipe, Winston Guo, Joseph P. Voth, Shivanshi Vaid, Hui Xie, Wei-Cheng Lu, Will Swanson, Andrew W. Grande, Mark R. Schleiss, Craig J. Bierle, Maxim C-J. Cheeran, Walter C. Low, Mohammed Alsharifi
Publikováno v:
PLoS ONE, Vol 15, Iss 10 (2020)
Zika virus (ZIKV) exhibits a tropism for brain tumor cells and has been used as an oncolytic virus to target brain tumors in mice with modest effects on extending median survival. Recent studies have highlighted the potential for combining virotherap
Externí odkaz:
https://doaj.org/article/0180d35c66234e22aec6d34b31b7bf80
Autor:
Shabihah Shahrudin, Cheng Chen, Shannon C David, Eve V Singleton, Justin Davies, Carl D Kirkwood, Timothy R Hirst, Michael Beard, Mohammed Alsharifi
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198182 (2018)
Rotavirus (RV) causes significant morbidity and mortality in developing countries, where children and infants are highly susceptible to severe disease symptoms. While live attenuated vaccines are available, reduced vaccine efficacy in developing coun
Externí odkaz:
https://doaj.org/article/f7f5b0a7c1ae42a0a73d429b3272f829
Autor:
Wisam H Al-Shujairi, Jennifer N Clarke, Lorena T Davies, Mohammed Alsharifi, Stuart M Pitson, Jillian M Carr
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169814 (2017)
We have previously reported that the absence of sphingosine kinase 1 (SK1) affects both dengue virus (DENV) infection and innate immune responses in vitro. Here we aimed to define SK1-dependancy of DENV-induced disease and the associated innate respo
Externí odkaz:
https://doaj.org/article/bc0680b6224843088c5b3312c6839fdb
Autor:
Mansour Ebrahimi, Parisa Aghagolzadeh, Narges Shamabadi, Ahmad Tahmasebi, Mohammed Alsharifi, David L Adelson, Farhid Hemmatzadeh, Esmaeil Ebrahimie
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96984 (2014)
The evolution of the influenza A virus to increase its host range is a major concern worldwide. Molecular mechanisms of increasing host range are largely unknown. Influenza surface proteins play determining roles in reorganization of host-sialic acid
Externí odkaz:
https://doaj.org/article/0de64721b5e84ec8ae1e75b7b5872a01
Autor:
Natalie E Stevens, Cara K Fraser, Mohammed Alsharifi, Michael P Brown, Kerrilyn R Diener, John D Hayball
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68895 (2013)
Passive immunotherapies utilising polyclonal antibodies could have a valuable role in preventing and treating infectious diseases such as influenza, particularly in pandemic situations but also in immunocompromised populations such as the elderly, th
Externí odkaz:
https://doaj.org/article/f57c6ebaae0d4f3ea32cdc726b166c2a
Autor:
Mohammed Alsharifi, Aulikki Koskinen, Danushka K Wijesundara, Jayaram Bettadapura, Arno Müllbacher
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68458 (2013)
MHCII molecules are heterodimeric cell surface proteins composed of an α and β chain. These molecules are almost exclusively expressed on thymic epithelium and antigen presenting cells (APCs) and play a central role in the development and function
Externí odkaz:
https://doaj.org/article/b06e3769da394153adb769bceaa0f62f
Autor:
Yoichi Furuya, Jennifer Chan, En-Chi Wan, Aulikki Koskinen, Kerrilyn R Diener, John D Hayball, Matthias Regner, Arno Müllbacher, Mohammed Alsharifi
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25765 (2011)
BACKGROUND: We have shown previously in mice, that infection with live viruses, including influenza/A and Semliki Forest virus (SFV), induces systemic partial activation of lymphocytes, characterized by cell surface expression of CD69 and CD86, but n
Externí odkaz:
https://doaj.org/article/ad2e61aeaf4142dda6b8c7ea03a54c3a