Výsledky vyhledávání - "Mohammed Al-Helal"

Oral Cysts Aetiology, Classification And Treatment

Autor: Abbas Al Mkenah *, Seraj Al Baik , Mohammed Al Helal , Fulwah Alsaleem , Abdullah Al Aethan , Muntasir Aynusah , Razan Alekhmimi , Ziyad Alharbi , Sarah Alanazi , Majed Alqahtani

Oral cysts are commonly seen by patients at outpatients' clinics, and because of their heterogeneity, it is essential for dentists to be well oriented to their types and classification. Many classification systems exist for oral cysts. They can be cl

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Cross-border movement, economic development and malaria elimination in the Kingdom of Saudi Arabia

Autor: Abdelmohsin M. O. Abdoon, Abdiasiis I. Omar, Ali M. Al-Shahrani, Ali Adam Ibrahim, Tageddin B. El Gamri, Abdullah Alhogail, Mohamed Elmubarak, Mohammed Al-Helal, Ibrahim M. Saeed, Xiao Hong Li, Tarig M. Abdelgader, Abdu A. Dahlan, Yousif Eldirdiry Elamin, Mohammed S. Alattas, Abdullah M. Assiri, Robert W. Snow, Joseph Maina, Mohammed H. Al Zahrani

Publikováno v: BMC Medicine
BMC Medicine, Vol 16, Iss 1, Pp 1-9 (2018)

Malaria at international borders presents particular challenges with regards to elimination. International borders share common malaria ecologies, yet neighboring countries are often at different stages of the control-to-elimination pathway. Herein,

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https://pubmed.ncbi.nlm.nih.gov/29940950

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Perceived Barriers to Breast Cancer Screening among Saudi Women at Primary Care Setting

Autor: Shaimaa Baher, Abdel-Aziz, Tarek Tawfik, Amin, Mohammed Baqir, Al-Gadeeb, Abdullah I, Alhassar, Ali, Al-Ramadan, Mohammed, Al-Helal, Mohammad, Bu-Mejdad, Lubna Abdulaziz, Al-Hamad, Eman Hussain, Alkhalaf

Publikováno v: Asian Pacific Journal of Cancer Prevention : APJCP

Background: Screening for breast cancer (BC) is of low rate in Saudi Arabia; although it is provided in the country free of charge to the population. This cross-sectional study aimed at investigating the perceived barriers towards BC screening in Al

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https://pubmed.ncbi.nlm.nih.gov/28950697

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The development of quinoloneesters as novel antimalarial agents targeting the Plasmodium falciparum bc1protein complex

Autor: Robin Cowley, Nicholas Fisher, Raman Sharma, Alison E. Shone, Suet C. Leung, Neil G. Berry, Alexandre S. Lawrenson, Giancarlo A. Biagini, Paul O´Neill, Mohammed Al-Helal, Stephen A. Ward

Publikováno v: Med. Chem. Commun.. 3:39-44

Using the Gould-Jacobs methodology a small array of 6- and 7-substituted quinolones have been prepared. Analogues in the 7-series express activity as low as 0.46 nM versus Plasmodium falciparum malaria parasites and docking studies performed in silic

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https://doi.org/10.1039/c1md00183c

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Progress toward malaria elimination in Jazan Province, Kingdom of Saudi Arabia: 2000–2014

Autor: Abdisalan M. Noor, Abdollah Alhogail, Robert W. Snow, Mohammed Akeel, Adil A. H. Alsheikh, Ahmed Sahly, Raafat F. Alhakeem, Abdulaziz A. BinSaeed, Ibrahim Hassan, Hussein Ageely, Ibrahim Bani, Ibrahim A. Faragalla, Abdullah M. Assiri, Tageddin B. ElGamri, Mohammed Alzahrani, Mohammed Al-Atas, Mohammed Al-Helal, David Kyalo

Publikováno v: Malaria Journal

Background The draft Global Technical Strategy for malaria aims to eliminate malaria from at least 10 countries by 2020. Yemen and Saudi Arabia remain the last two countries on the Arabian Peninsula yet to achieve elimination. Over the last 50 years,

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https://doi.org/10.1186/s12936-015-0858-1

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HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc 1 Complex

Autor: Brigitte Meunier, Thomas Antoine, Mohammed Al-Helal, Nicholas Fisher, Alexandre S. Lawrenson, Paul A. Stocks, Cindy Vallières, Neil G. Berry, Stephen A. Ward, Giancarlo A. Biagini, Paul M. O'Neill

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2012, 56 (7), pp.3739-3747. ⟨10.1128/AAC.00486-12⟩

The mitochondrial bc 1 complex is a multisubunit enzyme that catalyzes the transfer of electrons from ubiquinol to cytochrome c coupled to the vectorial translocation of protons across the inner mitochondrial membrane. The complex contains two distin

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https://hal.archives-ouvertes.fr/hal-03470770

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Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression

Autor: Hilary Ranson, Giancarlo A. Biagini, Thomas Antoine, Ashley J. Warman, Stephen A. Ward, Alexandre S. Lawrenson, Roslaini Abd Majid, Paul M. O'Neill, Mohammed Al-Helal, David J. Johnson, Nicholas Fisher

Publikováno v: The Journal of Biological Chemistry

Background: Cytochrome b mutations confer atovaquone resistance, resulting in antimalarial drug failures. Results: Mutation Y268S reduces bc1 catalytic turnover and stability. Conclusion: Reduction of catalytic turnover and iron-sulfur protein conten

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https://pubmed.ncbi.nlm.nih.gov/22282497

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Glycerol: An unexpected major metabolite of energy metabolism by the human malaria parasite

Autor: Nicholas Fisher, Giancarlo A. Biagini, Stephen A. Ward, Lu-Yun Lian, Abd Majid Roslaini, Patrick G. Bray, Mohammed Al-Helal

Publikováno v: Malaria Journal, Vol 8, Iss 1, p 38 (2009)
Malaria Journal

Background Malaria is a global health emergency, and yet our understanding of the energy metabolism of the principle causative agent of this devastating disease, Plasmodium falciparum, remains rather basic. Glucose was shown to be an essential nutrit

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https://doi.org/10.1186/1475-2875-8-38

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