Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Mohammed A. Dahab"'
Autor:
Ibrahim H. Eissa, Hazem Elkady, Mahmoud Rashed, Alaa Elwan, Mohamed Hagras, Mohammed A. Dahab, Mohammed S. Taghour, Ibrahim M. Ibrahim, Dalal Z. Husein, Eslam B. Elkaeed, Hanan A. Al-ghulikah, Ahmed M. Metwaly, Hazem A. Mahdy
Publikováno v:
Heliyon, Vol 10, Iss 2, Pp e24005- (2024)
In this study, a series of seven novel 2,4-dioxothiazolidine derivatives with potential anticancer and VEGFR-2 inhibiting abilities were designed and synthesized as VEGFR-2 inhibitors. The synthesized compounds were tested in vitro for their potentia
Externí odkaz:
https://doaj.org/article/941a6ba96f1444fc9f1952738aba1c7c
Autor:
Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Ibrahim H. Eissa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A group of EGFR inhibitors derived from thieno[2,3-d]pyrimidine nucleus was designed, synthesised, and examined as anti-proliferative lead compounds. MCF-7 and A549 cell lines were inhibited by 5b, the most active member. It had inhibitory partialiti
Externí odkaz:
https://doaj.org/article/318328a3c2e245ceb70a910f300bc6ba
Autor:
Mohammed S. Taghour, Hazem A. Mahdy, Maher H. Gomaa, Ahmed Aglan, Mahmoud Gomaa Eldeib, Alaa Elwan, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Mohamed M. Khalifa, Ibrahim H. Eissa, Hazem Elkady
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2063-2077 (2022)
In this study, a set of novel benzoxazole derivatives were designed, synthesised, and biologically evaluated as potential VEGFR-2 inhibitors. Five compounds (12d, 12f, 12i, 12l, and 13a) displayed high growth inhibitory activities against HepG2 and M
Externí odkaz:
https://doaj.org/article/f180310e302d49f29cd0dbeea3e88d77
Autor:
Eslam B. Elkaeed, Mohammed S. Taghour, Hazem A. Mahdy, Wagdy M. Eldehna, Nehal M. El-Deeb, Ahmed M. Kenawy, Bshra A. Alsfouk, Mohammed A. Dahab, Ahmed M. Metwaly, Ibrahim H. Eissa, Mohamed A. El-Zahabi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2191-2205 (2022)
New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects of these compounds were estimated against A549, Caco-2, HepG2, and MDA-MB-231. Compounds 13 and 14 showed compar
Externí odkaz:
https://doaj.org/article/23225f8a56d246569bcac354c3c67f09
Autor:
Hazem Elkady, Alaa Elwan, Hesham A. El-Mahdy, Ahmed S. Doghish, Ahmed Ismail, Mohammed S. Taghour, Eslam B. Elkaeed, Ibrahim H. Eissa, Mohammed A. Dahab, Hazem A. Mahdy, Mohamed M. Khalifa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 403-416 (2022)
A new series of benzoxazole derivatives were designed and synthesised to have the main essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were evaluated for all derivatives against two human cancer cell lines, MCF-7 and Hep
Externí odkaz:
https://doaj.org/article/67393c5d353040d2a6882e7cf732c5b3
Autor:
Ibrahim H. Eissa, Radwan El-Haggar, Mohammed A. Dahab, Marwa F. Ahmed, Hazem A. Mahdy, Reem I. Alsantali, Alaa Elwan, Nicolas Masurier, Samar S. Fatahala
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1587-1599 (2022)
A novel series of 2-thioacetamide linked benzoxazole-benzamide conjugates 1–15 was designed as potential inhibitors of the vascular endothelial growth factor receptor-2 (VEGFR-2). The prepared compounds were evaluated for their potential antitumor
Externí odkaz:
https://doaj.org/article/df00a10607564622a1dbea3897e95ec3
Autor:
Atef A. El-Hela, Marwa S. Abu Bakr, Mostafa M. Hegazy, Mohammed A. Dahab, Ayman Abo Elmaaty, Adel Ehab Ibrahim, Sami El Deeb, Hatem S. Abbass
Publikováno v:
Scientia Pharmaceutica, Vol 91, Iss 1, p 7 (2023)
Virtual screening of the potential lead chemotherapeutic phytochemicals from medicinal plants has useful application in the field of in-silico modelling and computer-based drug design by orienting and scoring ligands in the active binding site of a t
Externí odkaz:
https://doaj.org/article/0ab7b634f7ed4eff8be2b813a850def0
Publikováno v:
Natural Products and Bioprospecting, Vol 10, Iss 6, Pp 453-462 (2020)
Abstract Total 40 natural compounds were selected to perform the molecular docking studies to screen and identify the potent antiviral agents specifically for Severe Acute Respiratory Syndrome Coronavirus 2 that causes coronavirus disease 2019 (COVID
Externí odkaz:
https://doaj.org/article/5339026cbb384242a33a6cff5707ba2b
Autor:
Alaa Elwan, Abdallah E. Abdallah, Hazem A. Mahdy, Mohammed A. Dahab, Mohammed S. Taghour, Eslam B. Elkaeed, Ahmed B. M. Mehany, Ahmed Nabeeh, Mohammed Adel, Aisha A. Alsfouk, Hazem Elkady, Ibrahim H. Eissa
Publikováno v:
Molecules, Vol 27, Iss 15, p 5047 (2022)
This work is one of our efforts to discover potent anticancer agents. We modified the most promising derivative of our previous work concerned with the development of VEGFR-2 inhibitor candidates. Thirteen new compounds based on benzoxazole moiety we
Externí odkaz:
https://doaj.org/article/9b88464c4c084ba2bfee7e48638f798d
Autor:
Ahmed A. Al-Karmalawy, Mohammed A. Dahab, Ahmed M. Metwaly, Sameh S. Elhady, Eslam B. Elkaeed, Ibrahim H. Eissa, Khaled M. Darwish
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The rapid and global spread of a new human coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Here, we consider drug repurposing as
Externí odkaz:
https://doaj.org/article/045924b8534c459aa57283412aa09dab