Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mohammed A. Abdelsaid"'
Autor:
Sally L. Elshaer, Mohammed A. Abdelsaid, Ahmad Al-Azayzih, Parag Kumar, Suraporn Matragoon, Julian J. Nussbaum, Azza B. El-Remessy
Publikováno v:
Journal of Diabetes Research, Vol 2013 (2013)
Proliferative diabetic retinopathy (PDR) is the leading cause of blindness in working age Americans. We demonstrated that diabetes disturbs the homeostasis of nerve growth factor (NGF) resulting in accumulation of its precursor proNGF. Increases in p
Externí odkaz:
https://doaj.org/article/ae776a2b34d84b4d9c9a711663327628
Autor:
Kaleigh Foster, Joshua Moore, Faith Burnett, Deanna Bolduc, Sherif S Hafez, Maha Coucha, Mohammed A Abdelsaid
Publikováno v:
Stroke. 54
SARS-CoV-2 has killed millions of people globally and has left many with devastating health problems, including neurological deficits. SARS-CoV-2 invades endothelial cells via binding its Spike-protein with angiotensin-converting enzyme 2 (ACE2) rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9c02e658e4a5992f3ad8020594053ff
https://doi.org/10.1161/str.54.suppl_1.111
https://doi.org/10.1161/str.54.suppl_1.111
Publikováno v:
Stroke. 54
Diabetics are more vulnerable to SARS-CoV-2 cerebrovascular complications, including brain fog, cognitive impairment, and strokes. This study aims to identify the molecular mechanisms of SARS-CoV-2-induced cerebrovascular dysfunction in diabetes. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc938c60128ad912dffaee5f967620e0
https://doi.org/10.1161/str.54.suppl_1.110
https://doi.org/10.1161/str.54.suppl_1.110
Publikováno v:
Stroke. 45
Diabetes worsens the outcome and impairs recovery after stroke. We have previously shown that diabetes caused a nitration-dependent dysfunctional cerebral neovascularization via increased vascular endothelial growth factor (VEGF) signalling. Our rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a774c8ef81c06579fff0630547680cce
https://doi.org/10.1161/str.45.suppl_1.wmp77
https://doi.org/10.1161/str.45.suppl_1.wmp77
Autor:
Mohammed A Abdelsaid, Aisha Cobbs, Weiguo Li, Jessica Filosa, R. Clinton Webb, J Sullivan, Adviye Ergul
Publikováno v:
Hypertension. 60
Aims: Vascular injury including edema and hemorrhage after ischemic stroke is increased in diabetes. High-mobility group box 1 (HMGB1) is a DAMP passively released by necrotic cells that initiates pro-inflammatory signaling through binding to the TLR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e067189f241939c6b8c104bc00504fc1
https://doi.org/10.1161/hyp.60.suppl_1.a611
https://doi.org/10.1161/hyp.60.suppl_1.a611
Autor:
Mohammed A Abdelsaid, Azza El-Remessy
Publikováno v:
Circulation Research. 109
While reparative angiogenesis improves outcome of stroke and myocardial infarction; pathological angiogenesis aggravates tumors, psoriasis and diabetic retinopathy. We have previously shown that low levels of peroxynitrite (PN, 1µM) are required to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56ff43c2238d40d0a3be070cfefbe43d
https://doi.org/10.1161/res.109.suppl_1.ap315
https://doi.org/10.1161/res.109.suppl_1.ap315
Autor:
Mohammed M H, Al-Gayyar, Mohammed A, Abdelsaid, Suraporn, Matragoon, Bindu A, Pillai, Azza B, El-Remessy
Publikováno v:
British journal of pharmacology. 164(1)
Up-regulation of thioredoxin interacting protein (TXNIP), an endogenous inhibitor of thioredoxin (Trx), compromises cellular antioxidant and anti-apoptotic defences and stimulates pro-inflammatory cytokines expression, implying a role for TXNIP in ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c97d1127714c4ea75b6db717cddab152
https://pubmed.ncbi.nlm.nih.gov/21434880
https://pubmed.ncbi.nlm.nih.gov/21434880
Autor:
Mohammed M H, Al-Gayyar, Mohammed A, Abdelsaid, Suraporn, Matragoon, Bindu A, Pillai, Azza B, El-Remessy
Publikováno v:
The American journal of pathology. 177(3)
We have previously shown a causal role of peroxynitrite in mediating retinal ganglion cell (RGC) death in diabetic and neurotoxicity models. In the present study, the role of peroxynitrite in altering the antioxidant and antiapoptotic thioredoxin (Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::36c775a1c492f733f2120c95ecb2cd2c
https://pubmed.ncbi.nlm.nih.gov/27658715
https://pubmed.ncbi.nlm.nih.gov/27658715
Autor:
Barbara A. Mysona, Mohammed M. H. Al-Gayyar, Suraporn Matragoon, Mohammed A. Abdelsaid, Mona F. El-Azab, H. Uri Saragovi, Azza B. El-Remessy
Publikováno v:
Diabetologia. 58:644-644
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f50d3ea68e6c58a1d1deb5e719adff
https://doi.org/10.1007/s00125-014-3476-5
https://doi.org/10.1007/s00125-014-3476-5
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110388 (2014)
We have recently shown that thioredoxin interacting protein (TXNIP) is required for VEGF-mediated VEGFR2 receptor activation and angiogenic signal. Retinas from TXNIP knockout mice (TKO) exhibited higher cellular antioxidant defense compared to wild
Externí odkaz:
https://doaj.org/article/894f7bb96d484077bfa93112970416d2