Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mohammad-Reza Ghovanloo"'
Autor:
Mohammad-Reza Ghovanloo, Philip R. Effraim, Sidharth Tyagi, Peng Zhao, Sulayman D. Dib-Hajj, Stephen G. Waxman
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Cannabinol (CBN), an incompletely understood metabolite for ∆9-tetrahydrocannabinol, has been suggested as an analgesic. CBN interacts with endocannabinoid (CB) receptors, but is also reported to interact with non-CB targets, including var
Externí odkaz:
https://doaj.org/article/60407da0abdb4b1b9e5d0e2499727ac9
Autor:
Mohammad-Reza Ghovanloo, Sidharth Tyagi, Peng Zhao, Philip R. Effraim, Sulayman D. Dib-Hajj, Stephen G. Waxman
Publikováno v:
Channels, Vol 18, Iss 1 (2024)
ABSTRACTSexual dimorphism has been reported in multiple pre-clinical and clinical studies on pain. Previous investigations have suggested that in at least some states, rodent dorsal root ganglion (DRG) neurons display differential sex-dependent regul
Externí odkaz:
https://doaj.org/article/eae2c5a826c947b2ab6508b901efc025
Autor:
Sidharth Tyagi, Grant P. Higerd-Rusli, Mohammad-Reza Ghovanloo, Fadia Dib-Hajj, Peng Zhao, Shujun Liu, Dong-Hyun Kim, Ji Seon Shim, Kang-Sik Park, Stephen G. Waxman, Jin-Sung Choi, Sulayman D. Dib-Hajj
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113685- (2024)
Summary: Tumor necrosis factor α (TNF-α) is a major pro-inflammatory cytokine, important in many diseases, that sensitizes nociceptors through its action on a variety of ion channels, including voltage-gated sodium (NaV) channels. We show here that
Externí odkaz:
https://doaj.org/article/fd5e2249aa9a4d75bd40c729fcbfa8f5
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/ab20e6e326e243daa6d72ef6614f601c
Autor:
Mohammad-Reza Ghovanloo, Sulayman D. Dib-Hajj, Samuel J. Goodchild, Peter C. Ruben, Stephen G. Waxman
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Phytocannabinoids, found in the plant, Cannabis sativa, are an important class of natural compounds with physiological effects. These compounds can be generally divided into two classes: psychoactive and non-psychoactive. Those which do not impart ps
Externí odkaz:
https://doaj.org/article/baedbfaa8dce47ffb3e44ca8a92a4318
Publikováno v:
PLoS ONE, Vol 17, Iss 8 (2022)
Gramicidin is a monomeric protein that is thought to non-selectively conduct cationic currents and water. Linear gramicidin is considered an antibiotic. This function is considered to be mediated by the formation of pores within the lipid membrane, t
Externí odkaz:
https://doaj.org/article/9e58c7e03aee47e588e2f34ea64d4428
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
BackgroundSudden cardiac death (SCD) is an unexpected death that occurs within an hour of the onset of symptoms. Hereditary primary electrical disorders account for up to 1/3 of all SCD cases in younger individuals and include conditions such as cate
Externí odkaz:
https://doaj.org/article/7000404825074161915bb27dbf4c1128
Autor:
Lily Goodyer Sait, Altin Sula, Mohammad-Reza Ghovanloo, David Hollingworth, Peter C Ruben, BA Wallace
Publikováno v:
eLife, Vol 9 (2020)
Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of
Externí odkaz:
https://doaj.org/article/f7ec069f3ef44283b246e6a8cbe1f16d
Autor:
Mohammad-Reza Ghovanloo, Philip R. Effraim, Jun-Hui Yuan, Betsy R. Schulman, Deborah S. Jacobs, Sulayman D. Dib-Hajj, Stephen G. Waxman
Publikováno v:
Journal of Neurophysiology. 129:609-618
Mechanisms underlying pain after axonal injury remain elusive. A small subgroup of patients experience pain after corneal refractive surgery, providing a human pain model after well-defined injury to axons. Here we analyze a mutation (P610T) in Nav1.
Publikováno v:
The Neuroscientist. 28:318-334
Voltage-gated sodium (Nav) channels initiate action potentials in excitable tissues. Altering these channels’ function can lead to many pathophysiological conditions. Nav channels are composed of several functional and structural domains that could