Výsledky vyhledávání - "Mohammad Tauseef"

Akademický článek

FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity

Autor: Md Zahid Akhter, Pascal Yazbeck, Mohammad Tauseef, Mumtaz Anwar, Faruk Hossen, Sayanti Datta, Vigneshwaran Vellingiri, Jagdish Chandra Joshi, Peter T. Toth, Nityanand Srivastava, Stephen Lenzini, Guangjin Zhou, James Lee, Mukesh K. Jain, Jae-Won Shin, Dolly Mehta

Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114297- (2024)

Summary: The mechanical environment generated through the adhesive interaction of endothelial cells (ECs) with the matrix controls nuclear tension, preventing aberrant gene synthesis and the transition from restrictive to leaky endothelium, a hallmar

Externí odkaz: https://doaj.org/article/bd516fbc0c824efbadb97d48af59e582

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Akademický článek

High Dose Vardenafil Blunts the Hypertensive Effects of Toll-Like Receptor 3 Activation During Pregnancy

Autor: Dakshnapriya Balasubbramanian, Sathish Dharani, Mohammad Tauseef, Mansoor A. Khan, Ziyaur Rahman, Brett M. Mitchell

Publikováno v: Frontiers in Virology, Vol 1 (2021)

The maternal innate immune system plays a central role in preeclampsia (PE). Toll-like receptors (TLRs) are innate immune system receptors that recognize characteristics of extracellular endogenous ligands or pathogens, and their activation leads to

Externí odkaz: https://doaj.org/article/d107bc93e84e48038336a54474f65f20

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Akademický článek

SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages

Autor: Jagdish C. Joshi, Bhagwati Joshi, Ian Rochford, Sheikh Rayees, Md Zahid Akhter, Sukriti Baweja, Koteshwara Rao Chava, Mohammad Tauseef, Hazem Abdelkarim, Viswanathan Natarajan, Vadim Gaponenko, Dolly Mehta

Publikováno v: Cell Reports, Vol 30, Iss 12, Pp 4096-4109.e5 (2020)

Summary: Acute lung injury (ALI) is a lethal inflammatory lung disorder whose incidence is on the rise. Alveolar macrophages normally act to resolve inflammation, but when dysregulated they can provoke ALI. We demonstrate that monocyte-derived macrop

Externí odkaz: https://doaj.org/article/a7510b0e0cab4569ac4fefd525cc8cd7

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Akademický článek

Innovations and Patent Trends in the Development of USFDA Approved Protein Kinase Inhibitors in the Last Two Decades

Autor: Mohd. Imran, Syed Mohammed Basheeruddin Asdaq, Shah Alam Khan, Dhanalekshmi Unnikrishnan Meenakshi, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Yahya Mohzari, Ahmed Alrashed, Mohammed AlMotairi, Eman H. Alkhaldi, Abeer K. Alorabi, Ahmed Subeh Alshrari, Mohammad Tauseef, Abida, Saleh I. Alaqel, Ozair Alam, Md. Afroz Bakht

Publikováno v: Pharmaceuticals, Vol 14, Iss 8, p 710 (2021)

Protein kinase inhibitors (PKIs) are important therapeutic agents. As of 31 May 2021, the United States Food and Drug Administration (USFDA) has approved 70 PKIs. Most of the PKIs are employed to treat cancer and inflammatory diseases. Imatinib was t

Externí odkaz: https://doaj.org/article/042149ad6a3b48718874cc85daad4177

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Akademický článek

PAR2-Mediated cAMP Generation Suppresses TRPV4-Dependent Ca2+ Signaling in Alveolar Macrophages to Resolve TLR4-Induced Inflammation

Autor: Sheikh Rayees, Jagdish Chandra Joshi, Mohammad Tauseef, Mumtaz Anwar, Sukriti Baweja, Ian Rochford, Bhagwati Joshi, Morley D. Hollenberg, Sekhar P. Reddy, Dolly Mehta

Publikováno v: Cell Reports, Vol 27, Iss 3, Pp 793-805.e4 (2019)

Summary: Alveolar macrophages (AMs), upon sensing pathogens, trigger host defense by activating toll-like receptor 4 (TLR4), but the counterbalancing mechanisms that deactivate AM inflammatory signaling and prevent lethal edema, the hallmark of acute

Externí odkaz: https://doaj.org/article/d8edae5dc8544d3781fadced72fd0c63

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