Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mohammad Shadid"'
Publikováno v:
PLoS ONE, Vol 19, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/2a3d40df50044f2b887fa92fbb2d90c1
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 17:1281-1292
INTRODUCTION Antisense oligonucleotides (ASOs) have emerged as a promising novel drug modality that aims to address unmet medical needs. A record of six ASO drugs have been approved since 2016, and more candidates are in clinical development. ASOs ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd1b4a8e7ef4ed0cd0d8f4fb11fd38a
https://doi.org/10.1080/17425255.2021.1992382
https://doi.org/10.1080/17425255.2021.1992382
Autor:
Samantha Foley, Shawn Harriman, Jianbo Zhang, Marie Claire Mukashyaka, Bryan Mastis, John R Hadcock, Jenna Wood, Chia-Ling Wu, Nino Jungels, Kristin Ha, Mohammad Shadid, Huadong Sun
Publikováno v:
Pharmaceutical Research
Purpose Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) have shown promise in treating Duchenne muscular dystrophy (DMD). We evaluated a semi-mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) model to capture the relationsh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd3050837b15b9860574fc3a20a025d
https://doi.org/10.1007/s11095-021-03118-5
https://doi.org/10.1007/s11095-021-03118-5
Autor:
Mohammad Shadid, Eric Gaukel, Dongwei Zhao, Noriko Miyake, Yuusuke Tanaka, Tae Matsumoto, Koichi Miyake
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26e7178e5df25658f8ad1dae33ef89b6
https://doi.org/10.1530/endoabs.86.oc1.1
https://doi.org/10.1530/endoabs.86.oc1.1
Autor:
Afrand Kamali, Mohammad Shadid, Michael D. Smith, Jayaprakasam Bolleddula, Abhi Shah, Swapan Chowdhury
Publikováno v:
Drug Metabolism and Disposition. 48:1239-1245
TAK-164 is an antibody-drug conjugate (ADC) comprising human anti-guanylyl cyclase C (GCC) monoclonal antibody conjugated to indolinobenzodiazepine DNA alkylator IGN-P1 through a cleavable alanine-alanine dipeptide linker. TAK-164 is currently being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73c7b913bf7e365f1149b6e3dd3ec173
https://doi.org/10.1124/dmd.120.000194
https://doi.org/10.1124/dmd.120.000194
Autor:
Jayaprakasam, Bolleddula, Abhi, Shah, Mohammad, Shadid, Afrand, Kamali, Michael D, Smith, Swapan K, Chowdhury
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(11)
TAK-164 is an antibody-drug conjugate (ADC) comprising human anti-guanylyl cyclase C (GCC) monoclonal antibody conjugated to indolinobenzodiazepine DNA alkylator IGN-P1 through a cleavable alanine-alanine dipeptide linker. TAK-164 is currently being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5422710b88bcfd72f2a23ac6138637a8
https://pubmed.ncbi.nlm.nih.gov/32843329
https://pubmed.ncbi.nlm.nih.gov/32843329
Autor:
Abhi Shah, Mohammad Shadid, Jayaprakasam Bolleddula, Jing-Tao Wu, Swapan Chowdhury, Venkateswaran Shekar
Publikováno v:
Bioanalysis. 8:1693-1707
Background: Metabolite identification without radiolabeled compound is often challenging because of interference of matrix-related components. Results: A novel and an effective background subtraction algorithm (A-BgS) has been developed to process hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8207f88f3cc8484d1fec6b4e2ab742cc
https://doi.org/10.4155/bio-2016-0101
https://doi.org/10.4155/bio-2016-0101
Autor:
Swapan K. Chowdhury, Cindy Q. Xia, Jayaprakasam Bolleddula, Afrand Kamali, Mohammad Shadid, Adnan O. Abu-Yousif, Michael Smith, Abhi Shah
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S20-S21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c10605e6066a6d7e09830f1efe53ce5f
https://doi.org/10.1016/j.dmpk.2018.09.088
https://doi.org/10.1016/j.dmpk.2018.09.088
Autor:
Julia L. Shamshina, Bei-Ching Chuang, Jing-Tao Wu, Gabriela Gurau, Emily Guan, S. Hailu, Robert J. Griffin, Mohammad Shadid, Robin D. Rogers, Syed A. A. Rizvi, Swapan Chowdhury
Publikováno v:
MedChemComm. 6:1837-1841
The absorption, distribution, metabolism, and excretion (ADME) properties of a cholinium ionic liquid (IL) salt of the poorly soluble drug sulfasalazine were evaluated in both in vitro and in vivo models. The IL exhibited about a 4000-fold improvemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::011eb21d9aa9856567429c7ba9174c75
https://doi.org/10.1039/c5md00290g
https://doi.org/10.1039/c5md00290g
Publikováno v:
Bioorganicmedicinal chemistry. 25(12)
Antibody drug conjugates (ADCs) are large molecule therapeutics in which a cytotoxic payload is conjugated to a monoclonal antibody (mAb) via a linker. The molecules are designed to selectively bind to target-expressing cells, thus delivering therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba64e552d3ad2bd9f1ae84cbd2a8fb8
https://pubmed.ncbi.nlm.nih.gov/28438386
https://pubmed.ncbi.nlm.nih.gov/28438386