Stress Elicits Contrasting Effects on Rac1-Cofilin Signaling in the Hippocampus and Amygdala

Autor: Mihika Bose, Mohammad Sarfaraz Nawaz, Rakhi Pal, Sumantra Chattarji

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

There is accumulating evidence for contrasting patterns of stress-induced morphological and physiological plasticity in glutamatergic synapses of the hippocampus and amygdala. The same chronic stress that leads to the formation of dendritic spines in

Externí odkaz: https://doaj.org/article/f8aa35c2073441d5aed2d918eb671824

Imbalance of flight–freeze responses and their cellular correlates in the Nlgn3−/y rat model of autism

Autor: Natasha J. Anstey, Vijayakumar Kapgal, Shashank Tiwari, Thomas C. Watson, Anna K. H. Toft, Owen R. Dando, Felicity H. Inkpen, Paul S. Baxter, Zrinko Kozić, Adam D. Jackson, Xin He, Mohammad Sarfaraz Nawaz, Aiman Kayenaat, Aditi Bhattacharya, David J. A. Wyllie, Sumantra Chattarji, Emma R. Wood, Oliver Hardt, Peter C. Kind

Publikováno v: Anstey, N J, Kapgal, V, Tiwari, S, Watson, T C, Toft, A K H, Dando, O R, Inkpen, F H, Baxter, P S, Kozic, Z, Jackson, A D, He, X, Nawaz, M S, Kayenaat, A, Bhattacharya, A, Wyllie, D J A, Chattarji, S, Wood, E R, Hardt, O & Kind, P C 2022, ' Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3-/y rat model of autism ', Molecular Autism, vol. 13, 34 . https://doi.org/10.1186/s13229-022-00511-8

BackgroundMutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however differenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c236db287e28b698524b9c96f2a988
https://doi.org/10.1186/s13229-022-00511-8

Correction of amygdalar dysfunction in a rat model of fragile X syndrome

Autor: David J. A. Wyllie, Sonal Kedia, Paul G. Donlin-Asp, Sumantra Chattarji, Pradeep K. Mishra, Mohammad Sarfaraz Nawaz, Erin M. Schuman, Peter C. Kind, Giselle Fernandes, Mohammed Mostafizur Rahman, Aiman Kayenaat, Anupam Hazra, Dheeraj Songara

Publikováno v: Cell Rep.

Fragile X syndrome (FXS), a commonly inherited form of autism and intellectual disability, is associated with emotional symptoms that implicate dysfunction of the amygdala. However, current understanding of the pathogenesis of the disease is based pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e799bbf7a8522e4560eeecf528af8083

MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?

Autor: Nicoletta Landsberger, Anna Bergo, Elisa Bellini, Mohammad Sarfaraz Nawaz, Maria Maddalena Valente, Laura Rusconi, Chetan Chandola, Giulio Pavesi, Gilda Stefanelli, Charlotte Kilstrup-Nielsen, Marta Strollo, Isabella Barbiero

Publikováno v: Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 8 (2014)

Although Rett syndrome (RTT) represents one of the most frequent forms of severe intellectual disability in females worldwide, we still have an inadequate knowledge of the many roles played by MeCP2 (whose mutations are responsible for most cases of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b41793e2a2da3723e7e182fb8ce4fa8
http://hdl.handle.net/11383/2019402