Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mohammad Roghanian"'
Autor:
Hiraku Takada, Mohammad Roghanian, Victoriia Murina, Ievgen Dzhygyr, Rikinori Murayama, Genki Akanuma, Gemma C. Atkinson, Abel Garcia-Pino, Vasili Hauryliuk
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The (p)ppGpp-mediated stringent response is a bacterial stress response implicated in virulence and antibiotic tolerance. Both synthesis and degradation of the (p)ppGpp alarmone nucleotide are mediated by RelA-SpoT Homolog (RSH) enzymes which can be
Externí odkaz:
https://doaj.org/article/cfe3282d2ac845f788cfcf5c61081e5c
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Amino acid starvation in Escherichia coli activates the enzymatic activity of the stringent factor RelA, leading to accumulation of the alarmone nucleotide (p)ppGpp. The alarmone acts as an intercellular messenger to regulate transcription, translati
Externí odkaz:
https://doaj.org/article/025cc05a717646d5a8cbd1e01dfa636a
Autor:
Stine Vang Nielsen, Kathryn Jane Turnbull, Mohammad Roghanian, Rene Bærentsen, Maja Semanjski, Ditlev E. Brodersen, Boris Macek, Kenn Gerdes
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Type II toxin-antitoxin (TA) modules encode a stable toxin that inhibits cell growth and an unstable protein antitoxin that neutralizes the toxin by direct protein-protein contact. hipBA of Escherichia coli strain K-12 codes for HipA, a seri
Externí odkaz:
https://doaj.org/article/7a936f4f05fe4d779f30afaf9f227b84
Autor:
Hiraku Takada, Duy Dinh Do Pham, Abel Garcia-Pino, Magdalena Petrová, Hedvig Tamman, Dominik Rejman, Radek Pohl, Hanna Ainelo, Julien Caballero-Montes, Viktor Mojr, Steffi Jimmy, Vasili Hauryliuk, Katleen Van Nerom, Mohammad Roghanian
Publikováno v:
A C S Chemical Biology
While alarmone nucleotides guanosine-3′,5′-bisdiphosphate (ppGpp) and guanosine-5′-triphosphate-3′-diphosphate (pppGpp) are archetypical bacterial second messengers, their adenosine analogues ppApp (adenosine-3′,5′-bisdiphosphate) and ppp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d0b5e32d8c65a347400f85a2022ce0
https://doi.org/10.1021/acschembio.1c00398
https://doi.org/10.1021/acschembio.1c00398
Autor:
Vasili Hauryliuk, Amaury Payelleville, Kathryn Jane Turnbull, Mohammad Roghanian, Eric Cascales, Dukas Jurėnas, Alain Givaudan, Julien Brillard
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2021, 49 (14), pp.8384-8395. ⟨10.1093/nar/gkab608⟩
Nucleic Acids Research, 2021, 49 (14), pp.8384-8395. ⟨10.1093/nar/gkab608⟩
Nucleic acids research, 49 (14
Nucleic Acids Research, Oxford University Press, 2021, 49 (14), pp.8384-8395. ⟨10.1093/nar/gkab608⟩
Nucleic Acids Research, 2021, 49 (14), pp.8384-8395. ⟨10.1093/nar/gkab608⟩
Nucleic acids research, 49 (14
Bacteria have evolved sophisticated mechanisms to deliver potent toxins into bacterial competitors or into eukaryotic cells in order to destroy rivals and gain access to a specific niche or to hijack essential metabolic or signaling pathways in the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d465a9e5db3fb078f0e74d98e6c366
http://europepmc.org/articles/PMC8661411
http://europepmc.org/articles/PMC8661411
Autor:
Genki Akanuma, Fabio Trebini, Pavel Kudrin, Hiraku Takada, Rikinori Murayama, Abel Garcia-Pino, Julien Caballero-Montes, Steffi Jimmy, Vasili Hauryliuk, Mohammad Roghanian, Katleen Van Nerom
Publikováno v:
Nucleic Acids Research
Nucleic acids research, 49 (1
Nucleic acids research, 49 (1
In the Gram-positive Firmicute bacterium Bacillus subtilis, amino acid starvation induces synthesis of the alarmone (p)ppGpp by the RelA/SpoT Homolog factor Rel. This bifunctional enzyme is capable of both synthesizing and hydrolysing (p)ppGpp. To de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030d20a8da5634a5b51c145d1d4d82db
http://europepmc.org/articles/PMC7797070
http://europepmc.org/articles/PMC7797070
Autor:
Hedvig Tamman, Karin Ernits, Mohammad Roghanian, Andres Ainelo, Christina Julius, Anthony Perrier, Ariel Talavera, Hanna Ainelo, Rémy Dugauquier, Safia Zedek, Aurélien Thureau, Javier Perez, Gipsi Lima-Mendez, Regis Hallez, Gemma Atkinson, Vasili Hauryliuk, Abel Garcia-Pino
Stringent factors orchestrate bacterial cell reprogramming through increasing the level of the alarmones (p)ppGpp. In Beta- and Gammaproteobacteria, SpoT hydrolyses (p)ppGpp to counteract the synthetase activity of RelA. However, structural informati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2537046ef9f6c9d594f8375f7d322d92
https://doi.org/10.21203/rs.3.rs-1293174/v1
https://doi.org/10.21203/rs.3.rs-1293174/v1
Autor:
Hedvig Tamman, Karin Ernits, Mohammad Roghanian, Andres Ainelo, Christina Julius, Anthony Perrier, Ariel Talavera, Hanna Ainelo, Rémy Dugauquier, Safia Zedek, Aurelien Thureau, Javier Pérez, Gipsi Lima-Mendez, Régis Hallez, Gemma C. Atkinson, Vasili Hauryliuk, Abel Garcia-Pino
Publikováno v:
Tamman, H, Ernits, K, Roghanian, M, Ainelo, A, Julius, C, Perrier, A, Talavera, A, Ainelo, H, Dugauquier, R, Zedek, S, Thureau, A, Pérez, J, Lima-Mendez, G, Hallez, R, Atkinson, G, Hauryliuk, V & Garcia-Pino, A 2022, ' Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint ', Nature Chemical Biology, vol. 19, no. 3, pp. 334-345 . https://doi.org/10.1038/s41589-022-01198-x
Stringent factors orchestrate bacterial cell reprogramming through increasing the level of the alarmones (p)ppGpp. In Beta- and Gammaproteobacteria, SpoT hydrolyzes (p)ppGpp to counteract the synthetase activity of RelA. However, structural informati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4772338e0c43111593771880c74a62cb
https://pubmed.ncbi.nlm.nih.gov/36470996
https://pubmed.ncbi.nlm.nih.gov/36470996
Autor:
Mohammad Roghanian, Sofia Raquel Alves Oliveira, Ondřej Bulvas, Andres Ainelo, Yuriko Sakaguchi, Hiraku Takada, Kathryn Jane Turnbull, Tsutomu Suzuki, Dominik Rejman, Abel Garcia-Pino, Tanel Tenson, Hedvig Tamman, Vasili Hauryliuk, Tatsuaki Kurata, Radek Pohl, Gemma C. Atkinson, Tetiana Brodiazhenko
Publikováno v:
Molecular cell, 81 (15
Molecular cell
Molecular cell
RelA-SpoT Homolog (RSH) enzymes control bacterial physiology through synthesis and degradation of the nucleotide alarmone (p)ppGpp. We recently discovered multiple families of small alarmone synthetase (SAS) RSH acting as toxins of toxin-antitoxin (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415b726f2f1d92986b1f6be803b8b8a6
https://pubmed.ncbi.nlm.nih.gov/34174184
https://pubmed.ncbi.nlm.nih.gov/34174184
Autor:
Van Nerom K, Julien Caballero-Montes, Hiraku Takada, Fabio Trebini, Abel Garcia-Pino, Steffi Jimmy, Genki Akanuma, Pavel Kudrin, Hauryliuk, Mohammad Roghanian, Rikinori Murayama
In the Gram-positive Firmicute bacteriumBacillus subtilis, amino acid starvation induces synthesis of the alarmone (p)ppGpp by the multi-domain RelA/SpoT Homolog factor Rel. This bifunctional enzyme is capable of both synthesizing and hydrolysing (p)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0b2508aa11b799c484f31b3167af2f