Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Mohammad R. Marzabadi"'
Autor:
Laxminarayan G. Hegde, Mary W. Walker, Vrej Jubian, Mariusz Papp, Mohammad R. Marzabadi, Douglas A. Craig, Christophe P. G. Gerald, David H. Overstreet, Silke Miller, Gamini Chandrasena, Huailing Zhong, Toni D. Wolinsky, Douglas A. Marsteller, Xinyan Huang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:900-911
Neuropeptide Y (NPY) regulates physiological processes via receptor subtypes (Y1, Y2, Y4, Y5, and y6). The Y5 receptor is well known for its role in appetite. Based on expression in the limbic system, we hypothesized that the Y5 receptor might also m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::152b8da161e9f077a50457dd9cc641dc
https://doi.org/10.1124/jpet.108.144634
https://doi.org/10.1124/jpet.108.144634
Autor:
Irena Daniewska, John De Leon, Carlos Forray, Kim Andersen, Douglas A. Craig, Laxminarayan G. Hegde, Toni D. Wolinsky, Jiang Yu, Mohammad R. Marzabadi, Ron Kong, Kai Lu, Chen Chien-An, Boshan Li, John M. Wetzel
Publikováno v:
Journal of Medicinal Chemistry. 50:3870-3882
Melanin-concentrating hormone (MCH) is involved in the regulation of feeding, water balance, energy metabolism, general arousal and attention state, memory, cognitive functions, and psychiatric disorders. Herein, two new chemical series exemplified b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3204d0c9c648d9eec3964449da2f9d19
https://doi.org/10.1021/jm060381c
https://doi.org/10.1021/jm060381c
Autor:
D. Dong, C. J. Swanson, Kristen C. Klemenhagen, Luca Santarelli, Huailing Zhong, Laxminarayan G. Hegde, Michael Saxe, Indira Mendez, Douglas A. Craig, Mohammad R. Marzabadi, Denis J. David, Christophe P. G. Gerald, René Hen, K. A. Holick, X. I. Ping
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:237-248
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that plays a role in the modulation of food intake and mood. In rodents, the actions of MCH are mediated via the MCHR1 receptor. The goal of this study was to investigate the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea4f538fd03ef2199b641dabbcd8a3d
https://doi.org/10.1124/jpet.106.109678
https://doi.org/10.1124/jpet.106.109678
Autor:
Beth, Borowsky, Margaret M, Durkin, Kristine, Ogozalek, Mohammad R, Marzabadi, John, DeLeon, Bharat, Lagu, Rainer, Heurich, Harvey, Lichtblau, Zoya, Shaposhnik, Irena, Daniewska, Thomas P, Blackburn, Theresa A, Branchek, Christophe, Gerald, Pierre J, Vaysse, Carlos, Forray
Publikováno v:
Nature Medicine. 8:825-830
Melanin concentrating hormone (MCH) is an orexigenic hypothalamic neuropeptide, which plays an important role in the complex regulation of energy balance and body weight. Here we show that SNAP-7941, a selective, high-affinity MCH1 receptor (MCH1-R)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ac44e9703f185f24a62c45c73ec22b
https://doi.org/10.1038/nm741
https://doi.org/10.1038/nm741
Autor:
Mark G. Bock, Charles Gluchowski, Sriram Tyagarajan, Quanrong Shen, Tsing-Bau Chen, Mohammad R. Marzabadi, Carlos Forray, Dhanapalan Nagarathnam, Wai C. Wong, Stacey O'Malley, Barbara Francis, Dhar T G Murali, Douglas J. Pettibone, Jerry DiSalvo, Roger M. Freidinger, Miao Shou Wu, Raymond S.L. Chang, Bharat Lagu
Publikováno v:
European Journal of Pharmacology. 409:301-312
L-771,688 (SNAP 6383, methyl(4S)-4-(3, 4-difluorophenyl)-6-[(methyloxy)methyl]-2-oxo-3-[(?3-[4-(2-pyridin yl)-1-piperidinyl]propyl?amino)carbonyl]-1,2,3, 4-tetrahydro-5-pyrimidine carboxylate) had high affinity (Ki less than or = 1 nM) for [3H]prazos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9435f2baa4a2313af28f3841b322f801
https://doi.org/10.1016/s0014-2999(00)00854-2
https://doi.org/10.1016/s0014-2999(00)00854-2
Autor:
Robert J. Bendesky, Wai C. Wong, Theodore P. Broten, Fengqi Zhang, Dake Tian, Carlos Forray, James Fang, Sriram Tyagarajan, Dhanapalan Nagarathnam, and Kamlesh P. Vyas, Shou Wu Miao, George Chiu, Mohammad R. Marzabadi, T. G. Murali Dhar, Charles Gluchowski, Kathryn Schneck, Paul J. Kling, Raymond S.L. Chang, Bharat Lagu, Jack Zhang, Wanying Sun, Stacey O'Malley, Tsing B. Chen, Richard W. Ransom, Terry W. Schorn, Charles M. Harrell, John M. Wetzel
Publikováno v:
Journal of Medicinal Chemistry. 42:4764-4777
Dihydropyrimidinones such as compound 12 exhibited high binding affinity and subtype selectivity for the cloned human alpha(1a) receptor. Systematic modifications of 12 led to identification of highly potent and subtype-selective compounds such as (+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a155a502f01c3a2a70aa17db4eda0f
https://doi.org/10.1021/jm990200p
https://doi.org/10.1021/jm990200p
Autor:
Carlos Forray, Tsing B. Chen, Raymond S. L. Chang, Stacey O'Malley, Dhanapalan Nagarathnam, George Chiu, Dake Tian, Miao Shou Wu, Wai C. Wong, Bharat Lagu, Richard W. Ransom, Mohammad R. Marzabadi, Kanyin Zhang, Kamlesh P. Vyas, Charles Gluchowski, James Fang, Wanying Sun, Fengqi Zhang
Publikováno v:
Journal of Medicinal Chemistry. 42:4794-4803
Dihydropyrimidinones, such as 1, represent a novel class of α1a adrenoceptor antagonists with potential for the treatment of benign prostatic hyperplasia (BPH) (see part 1 of this series). Analysis of the metabolites of 1 revealed that 4-methoxycarb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c31af145a78e8fe8e37099a3289b08a5
https://doi.org/10.1021/jm990202+
https://doi.org/10.1021/jm990202+
Autor:
Miao Shou Wu, Stacey O'Malley, Kamlesh P. Vyas, Paul J. Kling, Raymond S.L. Chang, Wanying Sun, Wai C. Wong, Richard W. Ransom, Kanyin Zhang, John M. Wetzel, Jian Peng, Charles Gluchowski, Theodore P. Broten, Dhanapalan Nagarathnam, Carlos Forray, Fengqi Zhang, Dake Tian, Bharat Lagu, Tsing B. Chen, Mohammad R. Marzabadi
Publikováno v:
Journal of Medicinal Chemistry. 42:4804-4813
We have previously disclosed dihydropyridines such as 1a,b as selective alpha(1a) antagonists as a potential treatment for benign prostatic hyperplasia (BPH). The propensity of dihydropyridines toward an oxidation led us to find suitable replacements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644bb1e845f3476e1d3846442d956b07
https://doi.org/10.1021/jm9902032
https://doi.org/10.1021/jm9902032
Autor:
Dhanapalan Nagarathnam, Terry W. Schorn, Wai C. Wong, John M. Wetzel, Carlos Forray, Raymond S.L. Chang, William E. Heydorn, George Chiu, Theodore P. Broten, C. Gluchowski, Xingfang Hong, T. A. Branchek, Shou Wu Miao, James Fang, Mohammad R. Marzabadi
Publikováno v:
Journal of Medicinal Chemistry. 41:5320-5333
We report the synthesis and evaluation of novel alpha1a adrenoceptor subtype-selective antagonists. Systematic modification of the lipophilic 4,4-diphenylpiperidinyl moiety of the dihydropyridine derivatives 1 and 2 provided several highly selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2107805a48424aca74e2ba8260056335
https://doi.org/10.1021/jm980506g
https://doi.org/10.1021/jm980506g
Publikováno v:
Tetrahedron Letters. 39:5293-5296
A double protection strategy for the synthesis of the biologically important dihydropyridines is described. Deprotection followed by independent chemical manipulation of the C 3 - and C 5 -substituents allows one to access a variety of derivatives no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0b644c2172caab7b2c8bd77196f9c35
https://doi.org/10.1016/s0040-4039(98)01012-0
https://doi.org/10.1016/s0040-4039(98)01012-0