Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Mohammad Najlah"'
Autor:
Ibrahim Dumbuya, Ana Maria Pereira, Ibrahim Tolaymat, Adnan Al Dalaty, Basel Arafat, Matt Webster, Barbara Pierscionek, Mouhamad Khoder, Mohammad Najlah
Publikováno v:
Nanomaterials, Vol 14, Iss 13, p 1133 (2024)
Disulfiram (DS) has been shown to have potent anti-cancer activity; however, it is also characterised by its low water solubility and rapid metabolism in vivo. Biodegradable polylactic-co-glycolic acid (PLGA) polymers have been frequently employed in
Externí odkaz:
https://doaj.org/article/05e03c5a9e5547a99e3bb32e8266f44a
Autor:
Ayşe Kaya, Basel Arafat, Havovi Chichger, Ibrahim Tolaymat, Barbara Pierscionek, Mouhamad Khoder, Mohammad Najlah
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 65 (2023)
Zinc diethyldithiocarbamate (Zn (DDC)2), a disulfiram metabolite (anti-alcoholism drug), has shown a strong anti-cancer activity in vitro. However, its application was limited by its low aqueous solubility and rapid metabolism. In this study, the sol
Externí odkaz:
https://doaj.org/article/3cdea75d133b4f15ad9a94e0f6deb8fe
Publikováno v:
British Journal of Pharmacy, Vol 7, Iss 2 (2022)
Diethyldithiocarbamate zinc (Zn(DDC)2), has shown promising antineoplastic effects against a wide variety of cancers. However, this application was hindered by its poor water solubility. Therefore, complexation with cyclodextrin was used to enhance t
Externí odkaz:
https://doaj.org/article/44080c58d1964a19bf8db3285ab557d3
Publikováno v:
British Journal of Pharmacy, Vol 7, Iss 2 (2022)
Disulfiram (DS) has an excellent anti-viral activity; however, its low water-solubility and first-pass metabolism are limiting its clinical applications. Cyclodextrins (CDs) have been used as solubility enhancers and carriers of DS proposed for inhal
Externí odkaz:
https://doaj.org/article/10ab23272b4246aaa464d486c3631e5e
Development of Liposomal Formulations of Zinc Diethyldithiocarbamate for Colorectal Cancer Treatment
Publikováno v:
British Journal of Pharmacy, Vol 7, Iss 2 (2022)
(DDC)2Zn, disulfiram (DS) metabolite, has shown promising anticancer effects in vitro but further investigations in vivo are limited by its poor water solubility. In this study, liposomes are assessed as a delivery system for (DDC)2Zn. Liposomes were
Externí odkaz:
https://doaj.org/article/8e24b9fd933149e5b9b4829cdc874137
Autor:
Barbara Helena Barcaro Machado, Ivy Dantas De Melo E. Silva, Walter Marou Pautrat, James Frame, Mohammad Najlah
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Measuring outcomes from treatments to the skin is either reliant upon patient’s subjective feedback or scale-based peer assessments. Three-Dimensional stereophotogrammetry intend to accurately quantify skin microtopography before and after
Externí odkaz:
https://doaj.org/article/8071f50b50bc40789bfe0c8bc9ccc0aa
Autor:
Ana Maria Pereira, Ayse Kaya, Dan Alves, Niusha Ansari-Fard, Ibrahim Tolaymat, Basel Arafat, Mohammad Najlah
Publikováno v:
Molecules, Vol 27, Iss 17, p 5600 (2022)
Disulfiram (DS), known as an anti-alcoholism drug, has shown a potent antiviral activity. Still, the potential clinical application of DS is limited by its low water solubility and rapid metabolism. Cyclodextrins (CDs) have been widely used to improv
Externí odkaz:
https://doaj.org/article/8b8272d135004c14b1e03e2f1d784a76
Publikováno v:
Molecules, Vol 26, Iss 6, p 1698 (2021)
Unprotected exposure of skin to solar ultraviolet radiation (UVR) may damage the DNA of skin cells and can lead to skin cancer. Sunscreens are topical formulations used to protect skin against UVR. The active ingredients of sunscreens are UV filters
Externí odkaz:
https://doaj.org/article/71f760d0ac134ebfb98afd5718d55f09
Autor:
Ammar Said Suliman, Mouhamad Khoder, Ibrahim Tolaymat, Matt Webster, Raid G. Alany, Weiguang Wang, Abdelbary Elhissi, Mohammad Najlah
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 84 (2021)
Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion complexes of DDC-Cu with hyd
Externí odkaz:
https://doaj.org/article/bbc774cd54a942049565fd2f2b6443a3
Publikováno v:
Molecules, Vol 22, Iss 10, p 1661 (2017)
The present study compares the use of high generation G3 and low generation G0 Polyamidoamine (PAMAM) dendrimers as drug carriers of naproxen (NAP), a poorly water soluble drug. Naproxen was conjugated to G3 in different ratios and to G0 in a 1:1 rat
Externí odkaz:
https://doaj.org/article/7afeb67688834f138a0686ddee16fbce