Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Mohammad M Karimi"'
Autor:
Yi-Ting Tsai, Nogayhan Seymen, I Richard Thompson, Xinchen Zou, Warisha Mumtaz, Sila Gerlevik, Ghulam J Mufti, Mohammad M Karimi
Publikováno v:
eLife, Vol 13 (2024)
Retrotransposons (RTEs) have been postulated to reactivate with age and contribute to aging through activated innate immune response and inflammation. Here, we analyzed the relationship between RTE expression and aging using published transcriptomic
Externí odkaz:
https://doaj.org/article/1bd4e5dc38914a7780624f5ed7854f4f
Autor:
Sila Gerlevik, Nogayhan Seymen, Shan Hama, Warisha Mumtaz, I Richard Thompson, Seyed R Jalili, Deniz E Kaya, Alfredo Iacoangeli, Andrea Pellagatti, Jacqueline Boultwood, Giorgio Napolitani, Ghulam J Mufti, Mohammad M Karimi
Publikováno v:
eLife, Vol 13 (2024)
Mutational profiles of myelodysplastic syndromes (MDS) have established that a relatively small number of genetic aberrations, including SF3B1 and SRSF2 spliceosome mutations, lead to specific phenotypes and prognostic subgrouping. We performed a mul
Externí odkaz:
https://doaj.org/article/3ee4a561cd2144888814648747b54fd4
Autor:
Michelle C Ward, Siming Zhao, Kaixuan Luo, Bryan J Pavlovic, Mohammad M Karimi, Matthew Stephens, Yoav Gilad
Publikováno v:
eLife, Vol 7 (2018)
Transposable elements (TEs) comprise almost half of primate genomes and their aberrant regulation can result in deleterious effects. In pluripotent stem cells, rapidly evolving KRAB-ZNF genes target TEs for silencing by H3K9me3. To investigate the ev
Externí odkaz:
https://doaj.org/article/6a916d50f35e4746a3e38fb64ce5c91f
Autor:
Frances E Lock, Artem Babaian, Ying Zhang, Liane Gagnier, Sabrina Kuah, Antonia Weberling, Mohammad M Karimi, Dixie L Mager
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180659 (2017)
Remnants of ancient transposable elements (TEs) are abundant in mammalian genomes. These sequences contain multiple regulatory motifs and hence are capable of influencing expression of host genes. TEs are known to be released from epigenetic repressi
Externí odkaz:
https://doaj.org/article/e0e3813882ab40858518d0688878f776
Autor:
Peter J Thompson, Vered Dulberg, Kyung-Mee Moon, Leonard J Foster, Carol Chen, Mohammad M Karimi, Matthew C Lorincz
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006390 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1004933.].
Externí odkaz:
https://doaj.org/article/6beb50761d68402cac2cb07363ed9d53
Autor:
Peter J Thompson, Vered Dulberg, Kyung-Mee Moon, Leonard J Foster, Carol Chen, Mohammad M Karimi, Matthew C Lorincz
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004933 (2015)
Retrotransposition of endogenous retroviruses (ERVs) poses a substantial threat to genome stability. Transcriptional silencing of a subset of these parasitic elements in early mouse embryonic and germ cell development is dependent upon the lysine met
Externí odkaz:
https://doaj.org/article/6fcd03daa1e3422e917e30e69ef08f57
Autor:
Rita Rebollo, Mohammad M Karimi, Misha Bilenky, Liane Gagnier, Katharine Miceli-Royer, Ying Zhang, Preeti Goyal, Thomas M Keane, Steven Jones, Martin Hirst, Matthew C Lorincz, Dixie L Mager
Publikováno v:
PLoS Genetics, Vol 7, Iss 9, p e1002301 (2011)
The "arms race" relationship between transposable elements (TEs) and their host has promoted a series of epigenetic silencing mechanisms directed against TEs. Retrotransposons, a class of TEs, are often located in repressed regions and are thought to
Externí odkaz:
https://doaj.org/article/83d45773e2f74a8090ed73f9132f3099
Autor:
Irene Robles-Rebollo, Sergi Cuartero, Adria Canellas-Socias, Sarah Wells, Mohammad M. Karimi, Elisabetta Mereu, Alexandra G. Chivu, Holger Heyn, Chad Whilding, Dirk Dormann, Samuel Marguerat, Inmaculada Rioja, Rab K. Prinjha, Michael P. H. Stumpf, Amanda G. Fisher, Matthias Merkenschlager
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors show inducible genes and enhancers are regulated mainly by transcriptional burst frequency and that this is coordinated in single cells and individual alleles. Cohesin, which is important for inducible gene expression, is largely dis
Externí odkaz:
https://doaj.org/article/fc245dbd45344cc8acb6dc172ee905b9
Autor:
Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila, Diran Herebian, Mohammad M. Karimi, Elaine E. Irvine, Domhnall McHugh, Anne T. Schneider, Mihael Vucur, Verena Keitel, Jesús Gil, Dominic J. Withers, Tom Luedde, Mathias Heikenwalder
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 875-878 (2022)
Externí odkaz:
https://doaj.org/article/e280f4386f824a5c900ac7be2676e8ec
Autor:
Mohammad M. Karimi, Ya Guo, Xiaokai Cui, Husayn A. Pallikonda, Veronika Horková, Yi-Fang Wang, Sara Ruiz Gil, Gustavo Rodriguez-Esteban, Irene Robles-Rebollo, Ludovica Bruno, Radina Georgieva, Bhavik Patel, James Elliott, Marian H. Dore, Danielle Dauphars, Michael S. Krangel, Boris Lenhard, Holger Heyn, Amanda G. Fisher, Ondřej Štěpánek, Matthias Merkenschlager
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Developing T cells commit to either CD4/helper or CD8/cytotoxic lineage in the thymus, but how CD4 and CD8 coreceptors and TCR signaling dictate this selection process is still unclear. Here the authors use single cell RNA sequencing of mouse thymocy
Externí odkaz:
https://doaj.org/article/ce6d54e4a05749d99545339b720e286a