Efficacy of Prosopilosidine from Prosopis glandulosa var. glandulosa against Cryptococcus neoformans Infection in a Murine Model

Autor: Mohammad K. Ashfaq, Mohamed Sadek Abdel-Bakky, Mir Tahir Maqbool, Volodymyr Samoylenko, Aziz Abdur Rahman, Ilias Muhammad

Publikováno v: Molecules, Vol 23, Iss 7, p 1674 (2018)

In this study, 2,3-dihydro-1H-indolizinium alkaloid-prosopilosidine (PPD), that was isolated from Prosopis glandulosa, was evaluated against C. neoformans in a murine model of cryptococcosis. In vitro and in vivo toxicity of indolizidines were also e

Externí odkaz: https://doaj.org/article/f5ac8294a6234cf4b7692dd11e2235a0

Quantitative determination and pharmacokinetic study of fusaricidin A in mice plasma and tissues using ultra-high performance liquid chromatography-tandem mass spectrometry

Autor: Mohammad K. Ashfaq, Qiu Shi, Bharathi Avula, Ji-Yeong Bae, Ikhlas A. Khan, Mona H. Haron, Xing-Cong Li, Shaohua Guan, Shabana I. Khan, Maud Hinchee

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 170:187-192

Fusaricidins are a family of cyclic lipodepsipeptides that convey antifungal and antibacterial activity. Fusaricidin A (FA) is one of the Fusaricidins major compounds and it is showing promising activity against fungi and bacteria. In the present stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab308c87d6386826f395e65c56a2f13f
https://doi.org/10.1016/j.jpba.2019.03.042

A preliminary study on combination therapy of artemisinin dimer oxime and topotecan against nonsmall cell lung cancer in mice

Autor: Mir Tahir Maqbool, Mohammad K. Ashfaq, Mahmoud A. ElSohly, Mohamed S. Abdel-Bakky, Waseem Gul

Publikováno v: World Journal of Traditional Chinese Medicine, Vol 4, Iss 1, Pp 8-14 (2018)

Background: Artemisinin dimer oxime – dimer molecule synthesized from artemisinin possesses high bioavailability and marked in vitro anticancer activities against solid tumor-derived cell lines, endothelial cell proliferation, migration, and angiog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4a5757f3f26c14a62dee4f435a2d9f
http://www.wjtcm.net/article.asp?issn=2311-8571

Efficacy of Prosopilosidine from Prosopis glandulosa var. glandulosa against Cryptococcus neoformans Infection in a Murine Model

Autor: Volodymyr Samoylenko, Aziz Abdur Rahman, Mohammad K. Ashfaq, Mir Tahir Maqbool, Mohamed S. Abdel-Bakky, Ilias Muhammad

Publikováno v: Molecules, Vol 23, Iss 7, p 1674 (2018)
Molecules
Volume 23
Issue 7
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

In this study, 2,3-dihydro-1H-indolizinium alkaloid-prosopilosidine (PPD), that was isolated from Prosopis glandulosa, was evaluated against C. neoformans in a murine model of cryptococcosis. In vitro and in vivo toxicity of indolizidines were also e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16584e17a4b0d0305f4dad8a5ebfffb6
http://www.mdpi.com/1420-3049/23/7/1674

Are Females More Susceptible to EGCG Induced Hepatotoxicity?

Autor: Larry A. Walker, Mohamed F. Abd-Ellah, Mohammad K. Ashfaq, Farid M. Hamada, Zulfiqar Ali, Ibrahim G. Saleh, Floyd D. Wilson, Ikhlas A. Khan

Publikováno v: International Journal of Pharmacology and Clinical Trials. :1183-1189

Many recent studies and case reports have implicated Epigallocatechin-3-gallate (EGCG) to be hepatotoxic. As females consume weight control medications more than males, they are relatively more exposed to the harmful effects of EGCG on their livers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54c7957a1ee9ae182e0913bb5d93c37a
https://doi.org/10.12817/20518293.26.1.27703420