Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Mohammad Fallahi"'
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103190- (2024)
Summary: We present a protocol to generate highly multiplexed spatial data at cellular and subcellular resolutions using iterative indirect immunofluorescence imaging (4i). We describe streamlined steps for using 4i across fixed cultured cells, forma
Externí odkaz:
https://doaj.org/article/67203e541dcb49dd957caa3f3b8becb6
Publikováno v:
Veterinary Medicine and Science, Vol 10, Iss 1, Pp n/a-n/a (2024)
Abstract Background Trainability in dogs is affected by learning aptitude and memory capacity. While this trait has a heritable basis in canines, the specific genetic loci responsible for it remain unknown. Our previous results suggested that the BDN
Externí odkaz:
https://doaj.org/article/6be9791623ab46fdaba2515360226e9f
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Epigenetic mechanisms associated with the differentiation state of cancer cells and their heterogeneity influence tumor responses to oncogene-targeted therapies. In this study, the authors perform an epigenetic compound screen and single-cell analysi
Externí odkaz:
https://doaj.org/article/7fa8d14fcf1945ae8d04495e5d1b8978
Autor:
Aditi U. Gurkar, Andria R. Robinson, Yuxiang Cui, Xuesen Li, Shailaja K. Allani, Amanda Webster, Mariya Muravia, Mohammad Fallahi, Herbert Weissbach, Paul D. Robbins, Yinsheng Wang, Eric E. Kelley, Claudette M. St. Croix, Laura J. Niedernhofer, Matthew S. Gill
Publikováno v:
Redox Biology, Vol 18, Iss , Pp 191-199 (2018)
DNA damage is presumed to be one type of stochastic macromolecular damage that contributes to aging, yet little is known about the precise mechanism by which DNA damage drives aging. Here, we attempt to address this gap in knowledge using DNA repair-
Externí odkaz:
https://doaj.org/article/61d3695f21364a919fad44cfe583f052
Autor:
Anna Shcherbina, Jacqueline Larouche, Paula Fraczek, Benjamin A. Yang, Lemuel A. Brown, James F. Markworth, Carolina H. Chung, Mehwish Khaliq, Kanishka de Silva, Jeongmoon J. Choi, Mohammad Fallahi-Sichani, Sriram Chandrasekaran, Young C. Jang, Susan V. Brooks, Carlos A. Aguilar
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107964- (2020)
Summary: During aging, there is a progressive loss of volume and function in skeletal muscle that impacts mobility and quality of life. The repair of skeletal muscle is regulated by tissue-resident stem cells called satellite cells (or muscle stem ce
Externí odkaz:
https://doaj.org/article/4c25cc2531574597b3eba84ef930cfd5
Autor:
Natacha Comandante-Lou, Mehwish Khaliq, Divya Venkat, Mohan Manikkam, Mohammad Fallahi-Sichani
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007688 (2020)
Cell-to-cell variability generates subpopulations of drug-tolerant cells that diminish the efficacy of cancer drugs. Efficacious combination therapies are thus needed to block drug-tolerant cells via minimizing the impact of heterogeneity. Probabilis
Externí odkaz:
https://doaj.org/article/69b1a17685534dfc860ba61fbed15837
Autor:
Cari F. Kessing, Christopher C. Nixon, Chuan Li, Perry Tsai, Hiroshi Takata, Guillaume Mousseau, Phong T. Ho, Jenna B. Honeycutt, Mohammad Fallahi, Lydie Trautmann, J. Victor Garcia, Susana T. Valente
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 600-611 (2017)
HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency establishment. We postulated a “block-and-lock” functional cure approach based on properties of the Tat inhibitor didehydro-Cortistatin A (dCA). HIV-1
Externí odkaz:
https://doaj.org/article/cebe15104b8a475f8f02836b6d2d8b8d
Autor:
Sai Pradeep Velagapudi, Yiling Luo, Tuan Tran, Hafeez S. Haniff, Yoshio Nakai, Mohammad Fallahi, Gustavo J. Martinez, Jessica L. Childs-Disney, Matthew D. Disney
Publikováno v:
ACS Central Science, Vol 3, Iss 3, Pp 205-216 (2017)
Externí odkaz:
https://doaj.org/article/67181b2e0feb4f88923c0462ed463e11
Publikováno v:
Cancers, Vol 11, Iss 10, p 1480 (2019)
About eight percent of all human tumors (including 50% of melanomas) carry gain-of-function mutations in the BRAF oncogene. Mutated BRAF and subsequent hyperactivation of the MAPK signaling pathway has motivated the use of MAPK-targeted therapies for
Externí odkaz:
https://doaj.org/article/ff24f393ee064b5dbf8df6f46c181793
Autor:
Ann V. Griffith, Thomas Venables, Jianjun Shi, Andrew Farr, Holly van Remmen, Luke Szweda, Mohammad Fallahi, Peter Rabinovitch, Howard T. Petrie
Publikováno v:
Cell Reports, Vol 12, Iss 7, Pp 1071-1079 (2015)
T lymphocytes are essential mediators of immunity that are produced by the thymus in proportion to its size. The thymus atrophies rapidly with age, resulting in progressive diminution of new T cell production. This decreased output is compensated by
Externí odkaz:
https://doaj.org/article/dfea9ee59cf5442fba068048f8e21d91