Výsledky vyhledávání - "Mohammad F. Hadi"

Mechanics of a Fiber Network Within a Non-Fibrillar Matrix: Model and Comparison with Collagen-Agarose Co-gels

Autor: Victor H. Barocas, Mohammad F. Hadi, Victor K. Lai, Spencer P. Lake

Publikováno v: Annals of Biomedical Engineering. 40:2111-2121

While collagen is recognized as the predominant mechanical component of soft connective tissues, the role of the non-fibrillar matrix (NFM) is less well understood. Even model systems, such as the collagen-agarose co-gel, can exhibit complex behavior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d220f28a6aeb9637e11983c81b65fe
https://doi.org/10.1007/s10439-012-0584-6

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Simulated remodeling of loaded collagen networks via strain-dependent enzymatic degradation and constant-rate fiber growth

Autor: Jeffrey W. Ruberti, Edward A. Sander, Mohammad F. Hadi, Victor H. Barocas

Publikováno v: Mechanics of Materials. 44:72-82

Recent work has demonstrated that enzymatic degradation of collagen fibers exhibits strain-dependent kinetics. Conceptualizing how the strain dependence affects remodeling of collagenous tissues is vital to our understanding of collagen management in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0297a201521b39f7ff848a1560284c38
https://doi.org/10.1016/j.mechmat.2011.07.003

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Combining Displacement Field and Grip Force Information to Determine Mechanical Properties of Planar Tissue With Complicated Geometry

Autor: Amy A. Claeson, David J. Nuckley, Tina M. Nagel, Mohammad F. Hadi, Victor H. Barocas

Publikováno v: Journal of Biomechanical Engineering. 136

Soft-tissue characterization using planar biaxial testing and nominal stress–strain curves usually relies on certain conditions1: The sample should have a shape, (e.g., square or cruciform) that tends to produce homogeneous strain fields in the cen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee8482e52c43fae2b153d903aa27f9e
https://doi.org/10.1115/1.4028193

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Prefailure and Failure Mechanics of the Porcine Ascending Thoracic Aorta: Experiments and a Multiscale Model

Autor: Janna Goodrich, Victor H. Barocas, Sachin B. Shah, Patrick W. Alford, Hallie P. Wagner, Mohammad F. Hadi, Colleen M. Witzenburg

ATAA are dilatations of the arterial wall that result primarily from a weakening in the middle smooth muscle layer, or media, of the artery [1–3]. Aneurysm dissection and rupture pose serious risk of mortality and are the primary concerns for patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9dea12fff8ed05c973b456fe86a825
https://europepmc.org/articles/PMC4023665/

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Role of Lateral Interactions in Type IV Collagen Network Mechanics

Autor: Victor H. Barocas, Mohammad F. Hadi, Lazarina Gyoneva, Kevin D. Dorfman, Yoav Segal

Publikováno v: Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions.

The basement membrane is a specialized part of the extra-cellular matrix. It is usually characterized as a scaffold for epithelial cells but in some tissues it serves other, mechanical, roles [1]. The mechanical properties of the basement membrane ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0eb519e8b785b21b8ba14ac310ab9d84
https://doi.org/10.1115/sbc2013-14625

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Dissection of Porcine Ascending Aortic Media: Mechanical Characterization and Multiscale Model

Autor: Janna Goodrich, Hallie P. Wagner, Mohammad F. Hadi, Colleen M. Witzenburg, Victor H. Barocas, Sachin B. Shah

Ascending thoracic aortic aneurysm (aTAA) is a pathological condition with a high risk of dissection and rupture. Clinically, management of aTAA balances the risk of rupture with that of surgery-related complications. The risk of aneurysm rupture is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb498f65d2f2d9805e362c3b7d25ebfd
https://doi.org/10.1115/sbc2013-14610

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Generating Random Fiber Network Topologies That Mimic Previously Characterized Networks

Autor: Mohammad F. Hadi, Victor H. Barocas

Fibrous proteins, such as collagen and elastin, form the underlying structure of many soft tissues. These proteins form micrometer-scale networks of varying topology that play a role in governing the mechanics of tissues at larger length scales [1].

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71c25e3bca05a52d766c519bf524918e
https://doi.org/10.1115/sbc2013-14615

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Microscale fiber network alignment affects macroscale failure behavior in simulated collagen tissue analogs

Autor: Victor H. Barocas, Mohammad F. Hadi

Publikováno v: Journal of biomechanical engineering. 135(2)

A tissue's microstructure determines its failure properties at larger length scales, however, the specific relationship between microstructure and macroscopic failure in native and engineered soft tissues (such as capsular ligaments, aortic aneurysms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84966f9cbb4b0ca63d1448491dcc0c60
https://pubmed.ncbi.nlm.nih.gov/23445071

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A multiscale approach to modeling the passive mechanical contribution of cells in tissues

Autor: Robert T. Tranquillo, Victor H. Barocas, Victor K. Lai, Mohammad F. Hadi

Publikováno v: Journal of biomechanical engineering. 135(7)

In addition to their obvious biological roles in tissue function, cells often play a significant mechanical role through a combination of passive and active behaviors. This study focused on the passive mechanical contribution of cells in tissues by i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01335da5d80db146b31ae2545b23894
https://pubmed.ncbi.nlm.nih.gov/23720192

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Multiscale model predicts tissue-level failure from collagen fiber-level damage

Autor: Victor H. Barocas, Edward A. Sander, Mohammad F. Hadi

Publikováno v: Journal of biomechanical engineering. 134(9)

Excessive tissue-level forces communicated to the microstructure and extracellular matrix of soft tissues can lead to damage and failure through poorly understood physical processes that are multiscale in nature. In this work, we propose a multiscale

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937eab71969ac64ed1065ba48942ec92
https://pubmed.ncbi.nlm.nih.gov/22938372

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