Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Mohammad Abdel‐Halim"'
Autor:
Mohammad Abdel-Halim, Dalia S. El-Gamil, Mennatallah A. Hammam, Mohamed El-Shazly, Yi-Hsuan Wang, Po-Hsiung Kung, Yu-Cheng Chen, Michal Korinek, Ashraf H. Abadi, Matthias Engel, Tsong-Long Hwang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Targeting neutrophil function has gained attention as a propitious therapeutic strategy for diverse inflammatory diseases. Accordingly, a series of enone-based derivatives were developed to inhibit neutrophil-mediated inflammation, showing promise fo
Externí odkaz:
https://doaj.org/article/5b0476cbfd574282835e528b83c762a8
Autor:
Donia E. Hafez, Mariam Dubiel, Gabriella La Spada, Marco Catto, David Reiner-Link, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Holger Stark, Ashraf H. Abadi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Neurodegenerative diseases such as Alzheimer’s disease (AD) are multifactorial with several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed ligands (MTDLs) which interact with different biological targets relev
Externí odkaz:
https://doaj.org/article/524cab4f650e41a28fe24ba5d6089fe3
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1266 (2023)
Phosphodiesterase 5 (PDE5) inhibitors presented themselves as important players in the nitric oxide/cGMP pathway, thus exerting a profound impact on various physiological and pathological processes. Beyond their well-known efficacy in treating male e
Externí odkaz:
https://doaj.org/article/e640c6ae9a9240669b74d286c854ca03
Autor:
Lina Ammar, Hung-Yu Lin, Shou-Ping Shih, Tsen-Ni Tsai, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Ashraf H. Abadi
Publikováno v:
Molecules, Vol 28, Iss 2, p 840 (2023)
It has been shown that phosphodiesterase 5 (PDE5) inhibitors have anticancer effects in a variety of malignancies in both in vivo and in vitro experiments. The role of cGMP elevation in colorectal carcinoma (CRC) has been extensively studied. Additio
Externí odkaz:
https://doaj.org/article/274df712d5444331870d4552cbbc356d
Autor:
Alaa R. S. Leila, Mai H. A. Mousa, Efseveia Frakolaki, Niki Vassilaki, Ralf Bartenschlager, Grigoris Zoidis, Mohammad Abdel-Halim, Ashraf H. Abadi
Publikováno v:
ACS Omega, Vol 4, Iss 7, Pp 11440-11454 (2019)
Externí odkaz:
https://doaj.org/article/7a00eab8e5f244e19ef67493fd0eefb6
Autor:
Sarah H. Megahed, Mohammad Abdel-Halim, Amr Hefnawy, Heba Handoussa, Boris Mizaikoff, Nesrine A. El Gohary
Publikováno v:
Polymers, Vol 14, Iss 16, p 3339 (2022)
Quinic acid (QA) and its ester conjugates have been subjected to in-depth scientific investigations for their antioxidant properties. In this study, molecularly imprinted polymers (MIPs) were used for selective extraction of quinic acid (QA) from cof
Externí odkaz:
https://doaj.org/article/0bf41d261b824275987195376ae4902a
Autor:
Sarah S. Darwish, Po-Jen Chen, Mostafa M. Hamed, Reem A. Wagdy, Shun-Hua Chen, Ashraf H. Abadi, Mohammad Abdel-Halim, Tsong-Long Hwang, Matthias Engel
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 778 (2022)
For many inflammatory diseases, new effective drugs with fewer side effects are needed. While it appears promising to target the activation of the central pro-inflammatory transcription factor NF-κB, many previously discovered agents suffered from c
Externí odkaz:
https://doaj.org/article/4f94eed140294a279c7ecbceba04a02c
Autor:
Jehad Hamdy, Nouran Emadeldin, Mostafa M. Hamed, Efseveia Frakolaki, Sotirios Katsamakas, Niki Vassilaki, Grigoris Zoidis, Anna K. H. Hirsch, Mohammad Abdel-Halim, Ashraf H. Abadi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 632 (2022)
In today’s global plan to completely eradicate hepatitis C virus (HCV), the essential list of medications used for HCV treatment are direct-acting antivirals (DAAs), as interferon-sparing regimens have become the standard-of-care (SOC) treatment. H
Externí odkaz:
https://doaj.org/article/6b826baaf90a42318f6fadfdf96cc92e
Autor:
Ahmed K. ElHady, Dalia S. El-Gamil, Po-Jen Chen, Tsong-Long Hwang, Ashraf H. Abadi, Mohammad Abdel-Halim, Matthias Engel
Publikováno v:
Molecules, Vol 26, Iss 4, p 1001 (2021)
Clks have been shown by recent studies to be promising targets for cancer therapy, as they are considered key regulators in the process of pre-mRNA splicing, which in turn affects every aspect of tumor biology. In particular, Clk1 and -4 are overexpr
Externí odkaz:
https://doaj.org/article/e4dcdbd503ec43d1bc46dba165241951
Autor:
Ebaa M. El-Hossary, Mohammad Abdel-Halim, Eslam S. Ibrahim, Sheila Marie Pimentel-Elardo, Justin R. Nodwell, Heba Handoussa, Miada F. Abdelwahab, Ulrike Holzgrabe, Usama Ramadan Abdelmohsen
Publikováno v:
Marine Drugs, Vol 18, Iss 9, p 457 (2020)
Marine natural products have achieved great success as an important source of new lead compounds for drug discovery. The Red Sea provides enormous diversity on the biological scale in all domains of life including micro- and macro-organisms. In this
Externí odkaz:
https://doaj.org/article/338fdbddedae48b58cf81236e1a72ea2