Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Mohammad Abdel‐Halim"'
Autor:
Mohammad Abdel-Halim, Dalia S. El-Gamil, Mennatallah A. Hammam, Mohamed El-Shazly, Yi-Hsuan Wang, Po-Hsiung Kung, Yu-Cheng Chen, Michal Korinek, Ashraf H. Abadi, Matthias Engel, Tsong-Long Hwang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Targeting neutrophil function has gained attention as a propitious therapeutic strategy for diverse inflammatory diseases. Accordingly, a series of enone-based derivatives were developed to inhibit neutrophil-mediated inflammation, showing promise fo
Externí odkaz:
https://doaj.org/article/5b0476cbfd574282835e528b83c762a8
Autor:
Donia E. Hafez, Mariam Dubiel, Gabriella La Spada, Marco Catto, David Reiner-Link, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Holger Stark, Ashraf H. Abadi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Neurodegenerative diseases such as Alzheimer’s disease (AD) are multifactorial with several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed ligands (MTDLs) which interact with different biological targets relev
Externí odkaz:
https://doaj.org/article/524cab4f650e41a28fe24ba5d6089fe3
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1266 (2023)
Phosphodiesterase 5 (PDE5) inhibitors presented themselves as important players in the nitric oxide/cGMP pathway, thus exerting a profound impact on various physiological and pathological processes. Beyond their well-known efficacy in treating male e
Externí odkaz:
https://doaj.org/article/e640c6ae9a9240669b74d286c854ca03
Autor:
Lina Ammar, Hung-Yu Lin, Shou-Ping Shih, Tsen-Ni Tsai, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Ashraf H. Abadi
Publikováno v:
Molecules, Vol 28, Iss 2, p 840 (2023)
It has been shown that phosphodiesterase 5 (PDE5) inhibitors have anticancer effects in a variety of malignancies in both in vivo and in vitro experiments. The role of cGMP elevation in colorectal carcinoma (CRC) has been extensively studied. Additio
Externí odkaz:
https://doaj.org/article/274df712d5444331870d4552cbbc356d
Autor:
Alaa R. S. Leila, Mai H. A. Mousa, Efseveia Frakolaki, Niki Vassilaki, Ralf Bartenschlager, Grigoris Zoidis, Mohammad Abdel-Halim, Ashraf H. Abadi
Publikováno v:
ACS Omega, Vol 4, Iss 7, Pp 11440-11454 (2019)
Externí odkaz:
https://doaj.org/article/7a00eab8e5f244e19ef67493fd0eefb6
Autor:
Sarah H. Megahed, Mohammad Abdel-Halim, Amr Hefnawy, Heba Handoussa, Boris Mizaikoff, Nesrine A. El Gohary
Publikováno v:
Polymers, Vol 14, Iss 16, p 3339 (2022)
Quinic acid (QA) and its ester conjugates have been subjected to in-depth scientific investigations for their antioxidant properties. In this study, molecularly imprinted polymers (MIPs) were used for selective extraction of quinic acid (QA) from cof
Externí odkaz:
https://doaj.org/article/0bf41d261b824275987195376ae4902a
Autor:
Sarah S. Darwish, Po-Jen Chen, Mostafa M. Hamed, Reem A. Wagdy, Shun-Hua Chen, Ashraf H. Abadi, Mohammad Abdel-Halim, Tsong-Long Hwang, Matthias Engel
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 778 (2022)
For many inflammatory diseases, new effective drugs with fewer side effects are needed. While it appears promising to target the activation of the central pro-inflammatory transcription factor NF-κB, many previously discovered agents suffered from c
Externí odkaz:
https://doaj.org/article/4f94eed140294a279c7ecbceba04a02c
Autor:
Jehad Hamdy, Nouran Emadeldin, Mostafa M. Hamed, Efseveia Frakolaki, Sotirios Katsamakas, Niki Vassilaki, Grigoris Zoidis, Anna K. H. Hirsch, Mohammad Abdel-Halim, Ashraf H. Abadi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 632 (2022)
In today’s global plan to completely eradicate hepatitis C virus (HCV), the essential list of medications used for HCV treatment are direct-acting antivirals (DAAs), as interferon-sparing regimens have become the standard-of-care (SOC) treatment. H
Externí odkaz:
https://doaj.org/article/6b826baaf90a42318f6fadfdf96cc92e
Publikováno v:
Journal of Separation Science. 45:2488-2497
The first licensed polymerase inhibitor, baloxavir marboxil was recently approved for the treatment of influenza A and B viruses. Furthermore, there is growing interest in testing the antiviral activity of baloxavir marboxil against Coronavirus. Desp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f144b4c73001ce746d32bc8903bb6c18
https://doi.org/10.1002/jssc.202200020
https://doi.org/10.1002/jssc.202200020
Autor:
Ahmed K. ElHady, Dalia S. El-Gamil, Po-Jen Chen, Tsong-Long Hwang, Ashraf H. Abadi, Mohammad Abdel-Halim, Matthias Engel
Publikováno v:
Molecules, Vol 26, Iss 4, p 1001 (2021)
Clks have been shown by recent studies to be promising targets for cancer therapy, as they are considered key regulators in the process of pre-mRNA splicing, which in turn affects every aspect of tumor biology. In particular, Clk1 and -4 are overexpr
Externí odkaz:
https://doaj.org/article/e4dcdbd503ec43d1bc46dba165241951