Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mohammad, Alfatah"'
Autor:
Mohammad Alfatah, Jolyn Jia Jia Lim, Yizhong Zhang, Arshia Naaz, Trishia Yi Ning Cheng, Sonia Yogasundaram, Nashrul Afiq Faidzinn, Jovian Jing Lin, Birgit Eisenhaber, Frank Eisenhaber
Publikováno v:
eLife, Vol 12 (2024)
Uncovering the regulators of cellular aging will unravel the complexity of aging biology and identify potential therapeutic interventions to delay the onset and progress of chronic, aging-related diseases. In this work, we systematically compared gen
Externí odkaz:
https://doaj.org/article/6d69ed0e4b1c4eccb799998c85be894a
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Gerontology research on anti-aging interventions with drugs could be an answer to age-related diseases, aiming at closing the gap between lifespan and healthspan. Here, we present two methods for assaying chronological lifespan in human cell
Externí odkaz:
https://doaj.org/article/e6061c31863549b8ad5d29645c27f527
Autor:
Arshia Naaz, Yizhong Zhang, Nashrul Afiq Faidzinn, Sonia Yogasundaram, Rajkumar Dorajoo, Mohammad Alfatah
Publikováno v:
Cells, Vol 13, Iss 17, p 1470 (2024)
Aging is an inevitable biological process that contributes to the onset of age-related diseases, often as a result of mitochondrial dysfunction. Understanding the mechanisms behind aging is crucial for developing therapeutic interventions. This study
Externí odkaz:
https://doaj.org/article/d42d9725aff1416ba61e0f9d8c451e2f
Autor:
Corinna Jie Hui Goh, Liang Cui, Jin Huei Wong, Jacqueline Lewis, Megan Goh, Kiat Whye Kong, Lay Kien Yang, Mohammad Alfatah, Yoganathan Kanagasundaram, Shawn Hoon, Prakash Arumugam
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Phthalates are ubiquitously used as plasticizers in various consumer care products. Diethyl phthalate (DEP), one of the main phthalates, elicits developmental and reproductive toxicities but the underlying mechanisms are not fully understood
Externí odkaz:
https://doaj.org/article/1152b211aee64e30a42ae4ee3e6eb986
Autor:
Mohammad Alfatah, Jin Huei Wong, Vidhya Gomathi Krishnan, Yong Cheow Lee, Quan Feng Sin, Corinna Jie Hui Goh, Kiat Whye Kong, Wei Ting Lee, Jacqueline Lewis, Shawn Hoon, Prakash Arumugam
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-22 (2021)
Abstract Background Target of Rapamycin Complex 1 (TORC1) is a highly conserved eukaryotic protein complex that couples the presence of growth factors and nutrients in the environment with cellular proliferation. TORC1 is primarily implicated in link
Externí odkaz:
https://doaj.org/article/af97ae2870e8412f9d8a5a1c096604d7
Autor:
Swati Sinha, Choy-Eng Nge, Chung Yan Leong, Veronica Ng, Sharon Crasta, Mohammad Alfatah, Falicia Goh, Kia-Ngee Low, Huibin Zhang, Prakash Arumugam, Alexander Lezhava, Swaine L. Chen, Yoganathan Kanagasundaram, Siew Bee Ng, Frank Eisenhaber, Birgit Eisenhaber
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-18 (2019)
Abstract Background Phomafungin is a recently reported broad spectrum antifungal compound but its biosynthetic pathway is unknown. We combed publicly available Phoma genomes but failed to find any putative biosynthetic gene cluster that could account
Externí odkaz:
https://doaj.org/article/7802baec2e984d30bb9af5de5f8a5b7c
Publikováno v:
Cells, Vol 11, Iss 5, p 862 (2022)
Aging is the greatest challenge to humankind worldwide. Aging is associated with a progressive loss of physiological integrity due to a decline in cellular metabolism and functions. Such metabolic changes lead to age-related diseases, thereby comprom
Externí odkaz:
https://doaj.org/article/9b4f8c4c7519478582b5df97c77764e4
Autor:
Jin Huei Wong, Mohammad Alfatah, Mei Fang Sin, Hong May Sim, Chandra S. Verma, David P. Lane, Prakash Arumugam
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-17 (2017)
Abstract Background Protein–protein interactions (PPIs) are fundamental to the growth and survival of cells and serve as excellent targets to develop inhibitors of biological processes such as host-pathogen interactions and cancer cell proliferatio
Externí odkaz:
https://doaj.org/article/112b57435fc94facb72b41c215629057
Gerontology research on anti-aging interventions with drugs could be an answer to age-related diseases, aiming at closing the gap between lifespan and healthspan. Here, we present two methods for assaying chronological lifespan in human cells: 1) a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::336cb07b54e04dde5c0a95fd55f3390d
https://doi.org/10.21203/rs.3.rs-2833704/v1
https://doi.org/10.21203/rs.3.rs-2833704/v1
Autor:
Jin Huei Wong, Mohammad Alfatah, Kiat Whye Kong, Shawn Hoon, Wan Lin Yeo, Kuan Chieh Ching, Corinna Jie Hui Goh, Mingzi M Zhang, Yee Hwee Lim, Fong Tian Wong, Prakash Arumugam
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218189 (2019)
In this study, we report antifungal activity of auroramycin against Candida albicans, Candida tropicalis, and Cryptococcus neoformans. Auroramycin, a potent antimicrobial doubly glycosylated 24-membered polyene macrolactam, was previously isolated an
Externí odkaz:
https://doaj.org/article/b9a81b6dee34451a848bc7b8139cd530