Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Mohamed T Ghorbel"'
Autor:
Amy G. Harris, Vico Schot, Michele Carrabba, Dominga Iacobazzi, Mohamed T. Ghorbel, James P.K. Armstrong, Adam W. Perriman, Massimo Caputo, Giovanni Biglino, Francesca Bartoli-Leonard
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102899- (2024)
Summary: Surgical treatment of pediatric congenital heart disease with tissue grafts is a lifesaving intervention. Decellularization to reduce immunogenicity of tissue grafts is an increasingly popular alternative to glutaraldehyde fixation. Here, we
Externí odkaz:
https://doaj.org/article/b2b186d6fd6c4b6daab76d30fb44b9da
Autor:
Dominga Iacobazzi, Mohamed T. Ghorbel, Filippo Rapetto, Srinivas A. Narayan, Julia Deutsch, Tasneem Salih, Amy G. Harris, Katie L. Skeffington, Richard Parry, Giulia Parolari, Guillaume Chanoit, Massimo Caputo
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Background: Surgical treatment of congenital heart defects affecting the right ventricular outflow tract (RVOT) often requires complex reconstruction and multiple reoperations due to structural degeneration and lack of growth of currently available m
Externí odkaz:
https://doaj.org/article/018576be975a4df4beb49d2c6bf42bd1
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 861 (2024)
Congenital heart disease (CHD) is the most common birth defect, requiring invasive surgery often before a child’s first birthday. Current materials used during CHD surgery lack the ability to grow, remodel, and regenerate. To solve those limitation
Externí odkaz:
https://doaj.org/article/947af200072b4d849b4d6f455d42f2a3
Autor:
Katie L. Skeffington, Eltayeb Mohamed Ahmed, Filippo Rapetto, Guillaume Chanoit, Andrew R. Bond, Antonella Vardeu, Mohamed T. Ghorbel, M-Saadeh Suleiman, Massimo Caputo
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Cardioplegic cardioprotection strategies used during paediatric open-heart surgery remain suboptimal. Sildenafil, a phosphodiesterase 5 (PDE-5) inhibitor, has been shown to be cardioprotective against ischemia/reperfusion injury in a variety of exper
Externí odkaz:
https://doaj.org/article/e1676eda77224791b18921d484a6a09d
Autor:
Amy G. Harris, Tasneem Salih, Mohamed T. Ghorbel, Massimo Caputo, Giovanni Biglino, Michele Carrabba
Publikováno v:
Bioengineering, Vol 10, Iss 1, p 57 (2023)
Congenital heart disease (CHD) is the most predominant birth defect and can require several invasive surgeries throughout childhood. The absence of materials with growth and remodelling potential is a limitation of currently used prosthetics in cardi
Externí odkaz:
https://doaj.org/article/4c282c09353a44a38c332b808166f3aa
Autor:
Valeria Vincenza Alvino, Anita C. Thomas, Mohamed T. Ghorbel, Filippo Rapetto, Srinivas A. Narayan, Michael Kilcooley, Dominga Iacobazzi, Michele Carrabba, Marco Fagnano, William Cathery, Elisa Avolio, Massimo Caputo, Paolo Madeddu
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
The neonatal heart represents an attractive source of regenerative cells. Here, we report the results of a randomized, controlled, investigator-blinded preclinical study, which assessed the safety and effectiveness of a matrix graft cellularized with
Externí odkaz:
https://doaj.org/article/2389eec8c4f148f888db784ea00ac5a8
Autor:
Ambra Albertario, PhD, Megan M. Swim, PhD, Eltayeb Mohamed Ahmed, MCh, Dominga Iacobazzi, PhD, Michael Yeong, MBBS, Paolo Madeddu, MD, Mohamed T. Ghorbel, PhD, Massimo Caputo, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 364-384 (2019)
Summary: Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right
Externí odkaz:
https://doaj.org/article/9e42c604488549e4aa9bf8723d714f95
Autor:
Serban Stoica, Helena J M Smartt, Rachael Heys, Karen Sheehan, Terrie Walker-Smith, Andrew Parry, Richard Beringer, Iakovos Ttofi, Rebecca Evans, Lucy Dabner, Mohamed T Ghorbel, William Lansdowne, Barnaby C Reeves, Gianni D Angelini, Chris A Rogers, Massimo Caputo
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 63
OBJECTIVES Intermittent cold blood cardioplegia is commonly used in children, whereas intermittent warm blood cardioplegia is widely used in adults. We aimed to compare clinical and biochemical outcomes with these 2 methods. METHODS A single-centre,
Autor:
Dominga Iacobazzi, Indira Garaeva, Ambra Albertario, Myriam Cherif, Gianni D. Angelini, Massimo Caputo, Mohamed T. Ghorbel
Publikováno v:
Cellular Physiology and Biochemistry, Vol 36, Iss 1, Pp 384-394 (2015)
Background/Aim: Endothelial cell migration is required for physiological angiogenesis, but also contributes to various pathological conditions, including tumour vascularization. The mRNA expression of PP1cβ, the beta isoform of the catalytic PP1 sub
Externí odkaz:
https://doaj.org/article/4b5064306ccc4baa94571ec9df67352f
Autor:
Srinivas A. Narayan, Michele Carrabba, Marco Fagnano, Anita C Thomas, Michael Kilcooley, Filippo Rapetto, Paolo Madeddu, Elisa Avolio, Mohamed T. Ghorbel, Dominga Iacobazzi, William Cathery, Valeria Vincenza Alvino, Massimo Caputo
Publikováno v:
Frontiers in Bioengineering and Biotechnology
Alvino, V V, Thomas, A C, Ghorbel, M, Rapetto, F, Narayan, S, Kilcooley, M, Iacobazzi, D, Carrabba, M, Fagnano, M, Cathery, W R, Avolio, E, Caputo, M & Madeddu, P R 2021, ' Reconstruction of the swine pulmonary artery using a graft engineered with syngeneic cardiac pericytes ', Frontiers in Bioengineering and Biotechnology, vol. 9, 715717 . https://doi.org/10.3389/fbioe.2021.715717
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Alvino, V V, Thomas, A C, Ghorbel, M, Rapetto, F, Narayan, S, Kilcooley, M, Iacobazzi, D, Carrabba, M, Fagnano, M, Cathery, W R, Avolio, E, Caputo, M & Madeddu, P R 2021, ' Reconstruction of the swine pulmonary artery using a graft engineered with syngeneic cardiac pericytes ', Frontiers in Bioengineering and Biotechnology, vol. 9, 715717 . https://doi.org/10.3389/fbioe.2021.715717
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
The neonatal heart represents an attractive source of regenerative cells. Here, we report the results of a randomized, controlled, investigator-blinded preclinical study, which assessed the safety and effectiveness of a matrix graft cellularized with