Výsledky vyhledávání - "Mohamed Shaimi"

Novel Orally Bioavailable γ-Secretase Inhibitors with Excellent in Vivo Activity

Autor: Mohamed Shaimi, Jayesh Mistry, Huw D. Lewis, Jonathan D. Best, Christopher J. Welch, Andrew Madin, Michael Reilly, Fraser Murray, Timothy Harrison, Jonathan D.J. Wrigley, Ian Collins, Mark S. Shearman, Laura Catherine Cooper, Earl E. Clarke, Linda Elizabeth Keown

Publikováno v: Journal of Medicinal Chemistry. 52:3441-3444

The development of potent gamma-secretase inhibitors having substituted heterocycles attached to a benzobicyclo[4.2.1]nonane core is described. This work led to the identification of [6S,9R,11R]-2',3',4',5,5',6,7,8,9,10-decahydro-2-(5-(4-fluorophenyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a063e44deb50d5be29f0d0a39011301
https://doi.org/10.1021/jm900056p

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Shortcut to Selectivity: Make Them All and Let Preparative Chromatography Sort it Out

Autor: Derek W. Henderson, Christopher J. Welch, Dave Conlon, Mohamed Shaimi, Brenda Pipik, David J. Schenk

Publikováno v: Organic Process Research & Development. 14:905-907

Preparative chromatography was used to overcome the difficult selectivity challenge of accessing a single isomer of a mono tert-butyldimethylsilyl (TBDMS) derivative of an unsymmetrical diol. Chromatographic purification allowed rapid purification of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7da546140bf62b7883f1709340104661
https://doi.org/10.1021/op100095e

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Direct, preparative enantioselective chromatography of propranolol hydrochloride and thioridazine hydrochloride using carbon dioxide-based mobile phases

Autor: Linda R. Betz, James Lee, Martin Schultz, Mohamed Shaimi, William L Champion, Geiser Fiona

Publikováno v: Journal of chromatography. A. 865(1-2)

In this paper, we describe the direct, preparative enantioselective chromatography of racemic ( rac )-propranolol hydrochloride (HCl) and rac -thioridazine·HCl using Chiralpak AD chiral stationary phase and mobile phase systems containing carbon dio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d68ab27683d5f904125fafe3f54c6f
https://pubmed.ncbi.nlm.nih.gov/10674944

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Reactive resin facilitated preparation of an enantiopure fluorobicycloketone

Autor: David L. Hughes, Derek W. Henderson, Enrique Vazquez, Christopher J. Welch, Ian W. Davies, Audrey Wong, Jeffrey T. Kuethe, Mohamed Shaimi

Publikováno v: Organic & Biomolecular Chemistry. 2:168

A facile preparation of enantiopure ethyl (1S,5S,6S)-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylate 1 is described. The key feature of the synthesis involves copper-catalyzed enantioselective intramolecular cyclopropanation of a diazoketone to form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76bb003a4b792608b290070e57797ff
https://doi.org/10.1039/b312180c

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